2017 American Transplant Congress
The mTOR Signal Regulates Myeloid Derived Suppressor Cells Differentiation and Immunosuppressive Function in Acute Kidney Injury.
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
The mammalian target of rapamycin (mTOR) is a serine–threonine kinase that senses various environmental stimuli. The mTOR signal controls innate and adaptive immune response in…2017 American Transplant Congress
Inhibition of Multiple Nodes in the PI3K/Akt/mTOR Pathway Synergistically Suppresses Epstein-Barr Virus B Cell Lymphomas.
Division of Abdominal Transplantation, Stanford School of Medicine, Palo Alto, CA
Treating post-transplant lymphoproliferative disorders (PTLD) remains a clinical challenge due to adverse effects such as graft rejection. mTOR inhibitors, including rapamycin (RAPA), have shown both…2017 American Transplant Congress
Timing of Mesenchymal Stem Cell Infusions Affects Rejection Free and Overall Islet Allograft Survival.
We recently demonstrated that autologous, bone marrow-derived mesenchymal stem cells (MSC) promote allogeneic islet engraftment and survival in a streptozotocin induced, cynomolgus monkey model of…2016 American Transplant Congress
The mTORC2 Activation Is Critical for Hepato-Cytoprotection Against Ischemia and Reperfusion Injury.
Background & AimsRapamycin and Everolimus have been used in liver transplant patients, particularly those with calcineurin inhibitor-related nephrotoxicity and hepatocellular carcinoma. Although designed as mTORC1…2016 American Transplant Congress
Peritransplant Costimulation Blockade Combined with a Short-Course of Rapamycin Prevents Rejection of Vascularized Composite Allografts.
[Background] Reconstructive transplantation represents a valid therapeutic option after devastating tissue loss. Routine clinical application, however, is hampered by the toxicity of long-term maintenance immunosuppression.…2016 American Transplant Congress
Heterologous Persistent and Latent Viral Infections Do Not Impact Graft Survival.
1Duke University, Durham; 2Emory University, Atlanta.
Purpose: Infection induces costimulation-resistant memory T cells with heterologous alloreactivity. Rapamycin has been shown to mitigate the effect of these cells in transplant rejection. Previous…2016 American Transplant Congress
The Impact of a Novel Dual Adenosine Triphosphate-Competitive mTOR Inhibitor (TORKinib) on Alloimmunity and Transplant Survival.
Background: Rapamycin (RAPA), an immunosuppressive agent, inhibits the mechanistic target of Rapamycin (mTOR), the kinase subunit of two mTOR- containing complexes (mTORC1 and mTORC2). While…2016 American Transplant Congress
Rapamycin Prolongs Cardiac Allograft Survival in a Mouse Model by Inducing Myeloid-Derived Suppressor Cells.
Mammalian target of rapamycin (mTOR) inhibitors are the main immunosuppressive drugs for organ transplant recipients. Nevertheless, the mechanisms by which mTOR inhibitors induce immunosuppression is…2016 American Transplant Congress
Only 13% of Liver Transplant (LT) Recipients with Moderate to Severe Kidney Disease (KD) Tolerate Conversion to Everolimus and Reduced Tacrolimus (EVR/rTac).
Liver Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.
EVR/rTac has been reported to improve renal function in LT recipients with adequate kidney function (eGFR > 80ml/min); however, this strategy in LT patients with…2016 American Transplant Congress
Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR.
Pathology & Laboratory Medicine, UCLA, Los Angeles, CA.
Aim: Antibody-mediated rejection (AMR) is a major issue affecting solid organ transplants, manifesting with recruitment of monocytes to the endothelium of the allograft. The purpose…
American Transplant Congress abstracts