2022 American Transplant Congress
MTOR Inhibition Acts Directly on Endothelial Cells to Induce Contact-Independent Immune-Modulation of Allo-Specific T Cell Activation
Duke University School of Medicine, Durham, NC
*Purpose: Endothelial cells (ECs) form a barrier between vascularized organ allografts and host immunity and are known to provoke alloimmune responses. The mTOR inhibitor rapamycin…2022 American Transplant Congress
A Prospective Randomised, Controlled Trial Switching Sirolimus For Mycophenolate To Enhance Immunological Responses To Third Dose Covid-19 Vaccination In Kidney Transplant Recipients With Poor Baseline Humoral Immunity
*Purpose: Kidney transplant recipients (KTR) have inadequate responses to 2-dose COVID vaccination schedules and are at increased risk of severe COVID-19. Formation of T cell…2022 American Transplant Congress
CD14+ Monocytes Play a Critical Role in Initiating Xeno-Recognition, Costimulation and Immune-Responses to Porcine Endothelial Cells
Duke University School of Medicine, Durham, NC
*Purpose: Porcine endothelial cells (PECs) are the first barrier between a pig’s organ and circulating immune system. Unlike allogeneic immune responses, PECs fail to induce…2021 American Transplant Congress
Renal Preservation with Belatacept-Based versus Everolimus-Based Immunosuppression in Lung Transplant Recipients
*Purpose: Renal dysfunction is one of the most common long-term complications among lung transplant recipients (LTRs). Calcineurin-inhibitor (CNI) nephrotoxicity is a recognized contributor to renal…2021 American Transplant Congress
Belatacept and Rapamycin Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model
*Purpose: Desensitization with costimulation blockade and proteasome inhibition prior to kidney transplantation prevents early antibody-mediated rejection (AMR) and prolongs graft survival in highly sensitized nonhuman…2020 American Transplant Congress
MTOR-Inhibitor Regimens and Malignancy after Kidney Transplantation: Can the Risk Be Modified by Considering Human Leukocyte Antigen (HLA) Mismatch in Immunosuppression Selection?
*Purpose: We investigated the outcomes of mammalian target of rapamycin inhibitor (MTORI) regimens in adult kidney transplant (KT) recipients (KTRs) in categories of donor/recipient pre-transplant…2020 American Transplant Congress
The Effect of Undernutrition and Immunosuppression on Cytomegalovirus Specific T Cell Responses
1Pediatrics, Duke University, Durham, NC, 2Surgery, Duke University, Durham, NC
*Purpose: Cytomegalovirus (CMV) infection remains a significant issue in transplantation, especially in those who are undernourished. While undernutrition is associated with impaired T cell immunity…2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…2019 American Transplant Congress
TORC1 Inhibition In Vitro and in a Humanized Mouse Model Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, BWH/Harvard Medical School, Boston, MA
*Purpose: Optimizing Regulatory T cells (Tregs) survival is of utmost importance to maximize the efficacy of utilizing them in adoptive cell therapy. We previously described…2019 American Transplant Congress
Inhibition of mTORC2 Causes Hyper Phosphorylation of ERK Induced by Co-Ligation of HLA-I and II Antibody
*Purpose: Transplant recipients developing donor specific antibodies (DSA) are at risk for antibody-mediated rejection (AMR). It has been reported that as many as 30% of…
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