Articles tagged "Rapamycin"

2022 American Transplant Congress
CD14⁺ Monocytes Play a Critical Role in Initiating Xeno-Recognition, Costimulation and Immune-Responses to Porcine Endothelial Cells
H. Xu, A. Kirk, H. Xu
Duke University School of Medicine, Durham, NC
*Purpose: Porcine endothelial cells (PECs) are the first barrier between a pig’s organ and circulating immune system. Unlike allogeneic immune responses, PECs fail to induce…
2022 American Transplant Congress
MTOR Inhibition Acts Directly on Endothelial Cells to Induce Contact-Independent Immune-Modulation of Allo-Specific T Cell Activation
H. Xu, L. Wang, V. A. Bendersky, Q. Gao, Q. Li, A. D. Kirk, H. Xu
Duke University School of Medicine, Durham, NC
*Purpose: Endothelial cells (ECs) form a barrier between vascularized organ allografts and host immunity and are known to provoke alloimmune responses. The mTOR inhibitor rapamycin…
2022 American Transplant Congress
A Prospective Randomised, Controlled Trial Switching Sirolimus For Mycophenolate To Enhance Immunological Responses To Third Dose Covid-19 Vaccination In Kidney Transplant Recipients With Poor Baseline Humoral Immunity
M. J. Tunbridge¹, G. Perkins², T. Salehi¹, B. Grubor-Bauk³, B. Sim¹, T. Ying⁴, J. J. Singer⁵, S. C. Barry⁶, P. Hissaria⁷, S. Chadban⁸, P. T. Coates¹
¹Central and Northern Adelaide Renal and Transplant Services, Royal Adelaide Hospital, Adelaide, Australia, ²School of Biological Sciences, University of Adelaide, Adelaide, Australia, ³Basil Hetzel Institute, University of Adelaide, Adelaide, Australia, ⁴University of Sydney, Lilyfield, Ne, Australia, ⁵Kidney Node Laboratory, Charles Perkins Centre, The University of Sydney, The University of Sydney, Australia, ⁶School of Medical Sciences, University of Adelaide, Adelaide, Australia, ⁷Department of Immunology, Royal Adelaide Hospital, Adelaide, Australia, ⁸Department of Nephrology, Royal Prince Alfred Hospital, Sydney, Australia
*Purpose: Kidney transplant recipients (KTR) have inadequate responses to 2-dose COVID vaccination schedules and are at increased risk of severe COVID-19. Formation of T cell…
2021 American Transplant Congress
Renal Preservation with Belatacept-Based versus Everolimus-Based Immunosuppression in Lung Transplant Recipients
E. Sartain¹, K. Schoeppler¹, B. Crowther¹, J. Smith², A. Gray²
¹University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, ²Department of Medicine, Division of Pulmonary Sciences and Critical Care, University of Colorado, Denver, CO
*Purpose: Renal dysfunction is one of the most common long-term complications among lung transplant recipients (LTRs). Calcineurin-inhibitor (CNI) nephrotoxicity is a recognized contributor to renal…
2021 American Transplant Congress
Belatacept and Rapamycin Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model
R. Schmitz¹, Z. W. Fitch¹, M. Manook¹, J. Yoon¹, A. B. Farris², J. Kwun¹, S. J. Knechtle¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA
*Purpose: Desensitization with costimulation blockade and proteasome inhibition prior to kidney transplantation prevents early antibody-mediated rejection (AMR) and prolongs graft survival in highly sensitized nonhuman…
2020 American Transplant Congress
MTOR-Inhibitor Regimens and Malignancy after Kidney Transplantation: Can the Risk Be Modified by Considering Human Leukocyte Antigen (HLA) Mismatch in Immunosuppression Selection?
A. Santos¹, C. Chen¹, K. Alquadan², M. A. Leghrouz², X. Wen³
¹University of Florida, Gainesville, FL, ²Division of Nephrology, Hypertension, & Renal Transplantation, University of Florida, Gainesville, FL, ³Department of Pharmacy Practice, University of Rhode Island, Kingston, RI
*Purpose: We investigated the outcomes of mammalian target of rapamycin inhibitor (MTORI) regimens in adult kidney transplant (KT) recipients (KTRs) in categories of donor/recipient pre-transplant…
2020 American Transplant Congress
The Effect of Undernutrition and Immunosuppression on Cytomegalovirus Specific T Cell Responses
E. David¹, M. Zhu², W. Parker², N. MacIver¹, A. D. Kirk², E. T. Chambers¹
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Duke University, Durham, NC
*Purpose: Cytomegalovirus (CMV) infection remains a significant issue in transplantation, especially in those who are undernourished. While undernutrition is associated with impaired T cell immunity…
2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
J. B. Alhaddad, H. Allos, B. S. Al Dulaijan,, S. K. Eskandari, I. Sulkaj, G. Melhem, J. Y. Choi, J. R. Azzi
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…
2019 American Transplant Congress
Sex Specific Regulation of Podocyte-Specific Genes and Proteins Determines Glomerular Response to mTOR Inhibition
A. Kusch¹, O. AlDiab², D. Gürgen², C. Sünkel³, F. Grahammer⁴, M. Rinschen⁵, T. Huber⁴, N. Rajewsky³, D. Dragun²
¹Medizinische Klinik m. S. Nephrologie und Internistische Intensivmedizin, Charité Universitätsmedizin Berlin, Berlin, Germany, ²Medizinische Klinik m. S. Nephrologie und internistische Intensivmedizin, Charité Universitätsmedizin Berlin, Berlin, Germany, ³Max-Delbrück Center for Molecular Medicine, Berlin, Germany, ⁴III. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg - Eppendorf, Hamburg, Germany, ⁵CECAD Research Center, Universitätsklinikum Köln, Köln, Germany
*Purpose: mTOR inhibitors are increasingly used in transplantation with high interindividual variation in proteinuric responses. Although males have higher prevalence and faster progression of glomerular…
2019 American Transplant Congress
Sirolimus in Geriatric Kidney Transplantation: Modification of Outcomes by Pre-Transplant History of Malignancy or Cardiovascular Disease
H. Ibrahim¹, C. Chen², K. Alquadan³, X. Wen⁴, K. L. Womer³, A. H. Santos Jr¹
¹College of Medicine, Div. of Nephrology, Hypertension & Renal Transplantation, Univ. of Florida, Gainesville, FL, ²College of Pharmacy, Univ. of Florida, Gainesville, FL, ³College of Medicine, Div. of Nephrology, Hypertension & Renal Transplantation, Univ. of Florida, Gainesville, FL, ⁴College of Pharmacy, Univ. of Rhode Island, Kingston, RI
*Purpose: We analyzed the outcomes associated with sirolimus (SRL)-regimens in geriatric (>/=65-year-old) kidney transplant recipients (KTRs).*Methods: Using 2000-2016 Scientific Registry of Transplant Recipients data, Cox…

1
2
3
…
6
Next Page »