2018 American Transplant Congress
Determining the Utility of Protocol Biopsies in Kidney Transplant Recipients
1Virginia Commonwealth University, Falls Church; 2Inova Fairfax Hospital, Falls Church.
Protocol biopsies may allow for early detection and treatment of kidney transplant rejection or other correctable pathology, leading to improved graft survival. Unfortunately, biopsies may…2017 American Transplant Congress
Scoring of Distinct Tubular Injury Features and Assessment of Cellular Proliferation and of Non-Apoptotic Cell Death by the Novel Marker FACL4 Allow to Determine the Long-Term Prognosis of Renal Grafts.
Acute tubular injury (ATI) is common in renal grafts and is related to an inferior long-term function. There is no consensus which of the tubular…2017 American Transplant Congress
Early Introduction of Oral Paricalcitol in Renal Transplant Recipients. An Open-Label Randomized Study.
In stable renal transplant recipients with hyperparathyroidism, the vitamin D agonist paricalcitol reduces level of proteinuria. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. The…2017 American Transplant Congress
Infusion of Polyclonal Tregs Modulates Subclinical Kidney Transplant Inflammation: Final Report of TASK Pilot Trial.
Purpose:Treg therapy can reverse established inflammation in animal models. We conducted a pilot safety & feasibility trial of Treg therapy for subclinical kidney transplant inflammation.Methods:Peripheral…2017 American Transplant Congress
Podocyte-Specific Knockdown of SHROOM3 Causes Albuminuria and Foot-Process Effacement by Interaction with FYN.
Nephrology, Medicine, Icahn School of Medicine, New York, NY
In the translational GoCAR study, we identified that a CKD-associated SHROOM3-SNP, and tubular SHROOM3 expression correlated with the development of renal fibrosis post-transplant. The SNP…2017 American Transplant Congress
Quantitative Analysis of 10-Year Surveillance Renal Allograft Biopsies.
Introduction. Assessing late histologic changes in renal allografts is important to investigating etiology and devising treatment. Compared to the usual semi-quantitative reading by a renal…2017 American Transplant Congress
C3d-Binding Anti-DQ DSA Is Associated with a High Risk for Late ABMR and Graft Failure in Stable Kidney Transplant Recipients.
Introduction:Donor specific anti-HLA antibodies (DSA) are a major cause of antibody-mediated rejection (ABMR) and poor graft outcome in kidney transplant recipients (KTR). Critical issue is…2017 American Transplant Congress
The Impact of Marginal Factors on the Postoperative Kidney Function of Complex Living Donors for Kidney Transplantation.
Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan
BackgroundMedically complex living donors with marginal factors are increasing.MethodsBetween January 2008 and May 2015, 639 living donors for kidney transplantation were included. Marginal factors for…2017 American Transplant Congress
Short Term Renal Allograft Outcomes Following Treatment of Early Subclinical Borderline Changes on Surveillance Biopsies.
University of Michigan, Ann Arbor, MI
There is no consensus on treating subclinical borderline changes on surveillance biopsy in kidney transplant (KT) recipients. We examined whether treatment with pulsed corticosteroids led…2017 American Transplant Congress
The Value of Protocol Biopsy at Third Month After Kidney Transplant: A Single-Center Cohort Analysis.
Introduction: In spite of publications reporting higher detection of subclinical rejection (SR) with protocol biopsies in kidney transplant (KT) recipients there is no recommendation with…
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