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Articles tagged "Proliferation"

  • 2018 American Transplant Congress

    Different Expression Patterns of Exosomal miRNAs under Cyclosporin A and Rapamycin Treatment in Distinct Aggressiveness Colorectal Carcinomas

    V. Tubita,1 M. Ramírez-Bajo,1 J. Lozano,2 D. Moya-Rull,1 J. Rovira,3 J. Campistol,4,5,6 F. Diekmann,1,4,5,6 I. Revuelta.1,4,5,6

    1Experimental Laboratory of Nefrology and Kidney Transplant (LENIT). Biomedical Research Clinic Foundation (FCRB), Barcelona, Spain; 2Bioinformatics Platform, CIBEREHD, Barcelona, Spain; 3Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; 4Renal Transplant Unit. Department of Nephrology and Kidney Transplant. Hospital Clinic, Barcelona, Spain; 5REDinREN, Madrid, Spain; 6Barcelona University, Barcelona, Spain.

    The aggressiveness of colorectal cancer (CRC) in kidney transplantation is much more significant than the increase in its incidence compared with the general population. The…
  • 2018 American Transplant Congress

    Activation Requirements of Costimulation Blockade-Resistant CD4 T Cells

    J. Espinosa, B. Adams, J. Kearns, F. Shaw, R. Osborne, T. Woody, M. Ellis, J. Cheeseman, A. Kirk.

    Duke University, Durham.

    T cells lose costimulation dependence following primary activation and many phenotypes of terminally differentiated cells have been identified as contributing to costimulation blockade (CoB)-resistant rejection…
  • 2018 American Transplant Congress

    Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells on Hepatocytes Proliferation after Small-for-Size Liver Transplantation via RHO/ROCK Pathway

    L. Chen, J. Zheng, J. Cai, J. Yao, K. Zeng, Y. Zhang, Y. Yang.

    Department of Liver Transplantation, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    Exosomes from umbilical cords-derived mesenchymal stem cells (UC-MSCs-Ex) have been recognized as their ability to promote tissue regeneration in many animal models. However, the in…
  • 2017 American Transplant Congress

    Preceeding the Rejection: Clinical Results of a Saliva Test After Renal Transplantation.

    D. Abendroth,1 M. Marzinzig,1 M. Stangl.2

    1Dept. of Surgery, University of Ulm, Ulm, Germany; 2Dept. of Visceral and Transplant Surgery, Ludwigs-Maximilians-Universität, Munich, Germany

    Introduction There remains a need for biomarker in transplantation for monitoring and early identification of rejection episodes (R). We developed a colorimetric assay to detect…
  • 2017 American Transplant Congress

    IL-33 Enhances the Ability of Dendritic Cells to Expand Human Regulatory T Cells.

    Y. Zhao,1 H. Zhang,1 L. Mathews,1 H. Turnquist,1,2 A. Thomson.1,2

    1Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Introduction:The importance of increasing the number of regulatory T cells (Treg) relative to T effectors for the promotion of long-term experimental allograft survival/tolerance is well-established.…
  • 2017 American Transplant Congress

    Experimental Study of Hepatocyte Proliferation Regulated by miR26a.

    J. Zhou, X. Yuan, W. Ju, X. Jiao, D. Wang, X. Zhu, X. He.

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Objective To investigate mechanisms of regulation on hepatocyte proliferation by miRNAs. Methods Normal hepatocyte in ivtro was transfected with vectors harboring Ad5/anti-miR26a or Ad5/miR26a, and…
  • 2016 American Transplant Congress

    ASC-Deficient Dendritic Cells Exhibit Activation Defects and a Reduced Ability to Stimulate Allogeneic T Cells.

    A. Scheinok, A. Shigeoka, S. Kasimsetty, R. Elahimehr, D. McKay.

    Medicine, University of California-San Diego, La Jolla, CA.

    Donor dendritic cell (DC) activation causes adaptive immune responses that lead to rejection of transplanted allografts. Accumulating data suggest that inflammasome assembly within interstitial DCs…
  • 2016 American Transplant Congress

    Novel Effect of miR-26a:Mdm2:p53 Pathway on Mouse Liver Regeneration.

    J. Zhou, W. Ju, X. Yuan, X. Jiao, D. Wang, X. Zhu, X. He.

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    BACKGROUND: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches…
  • 2016 American Transplant Congress

    ESM1 Gene Promotes Hepatocyte Proliferation Through NF-κB Signal Pathway.

    J. Zhou, W. Ju, X. Jiao, X. Zhu, X. He.

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    BACKGROUND: Effective and timely liver regeneration is pivotal in the prevention of fetal small-for-size syndrome after living donor liver transplantation or split liver transplantation. Our…
  • 2016 American Transplant Congress

    FGF and Wnt Signaling in Pancreatic Progenitor and Beta-Cell Growth.

    S. Afelik,1 N. Yonan,1 B. Pool,2 J. Jensen,2 J. Oberholzer.1

    1Surgery, Division of Transplantation, University of Illinois, Chicago, IL; 2Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Foundation, Cleveland, OH.

    Beta-cell replacement therapy offersa cure for diabetes, but this is limited by the lack of readilyavailable supply of cells. Our goal is generate enough beta-cells…
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