Articles tagged "Prediction models"

2020 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
R. El Fekih¹, A. Alghamdi¹, J. Hurley², C. Coticchia², J. Choi¹, H. Allos¹, S. Eskandari¹, S. Bentink², V. Tadigotla², L. Riella¹, J. Markmann³, K. Safa³, R. Formica⁴, J. Skog², J. Azzi¹
¹Medecine, Brigham and Women's Hospital, Boston, MA, ²Exosome Diagnostics Inc., Waltham, MA, ³Massachusetts General Hospital, Boston, MA, ⁴Yale School of Medecine, New Haven, CT
*Purpose: Monitoring kidney transplant rejection by repeated biopsies might result in increased procedural complications and cost. Exosomes are nanometer-sized vesicles released by cells carrying trans…
2020 American Transplant Congress
Novel micro-RNA and Microbiome Signature Profiles as Biomarkers for Predicting the Risk of Autoimmune Type 1 Diabetes Development
P. Chhabra¹, G. Ricardo¹, A. Spano², V. Mas¹, M. Timko², K. Brayman¹
¹Dept of Surgery, University of Virginia Health System, Charlottesville, VA, ²Dept of Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To identify reliable microRNA (miRNA) and microbiome biomarkers for predicting risk of autoimmune beta-cell destruction in type 1 diabetes (T1D) and to investigate alterations…
2019 American Transplant Congress
Predicting Kidney Discards with Donor Admission Text
A. Placona, C. Martinez, B. Carrico
United Network for Organ Sharing, Richmond, VA
*Purpose: Kidney discard rates have increased in part due to technological advancements and deceased donor policy updates that allow for recovery of organs at increased…
2019 American Transplant Congress
Risk Stratification of Patients Undergoing Simultaneous Liver Transplantation and Cardiac Surgery
T. Diago Uso, G. D'Amico, S. Armanyous, L. Lomaglio, B. Eghtesad, M. Fujiki, F. Aucejo, K. Sasaki, N. K. Menon, M. Fares, M. Tong, K. Hashimoto, C. Miller, C. Quintini
Cleveland Clinic, Cleveland, OH
*Purpose: Evaluate risk factors and outcomes of combined liver transplantation (OLT) and cardiac surgery, including coronary artery grafting and valve replacement.*Methods: Between 1/2005 and 8/2018,…
2019 American Transplant Congress
More Than Meets the Eye: The Use of Serial Intravascular Ultrasound for Assessment of Cardiac Allograft Vasculopathy after Heart Transplantation
Y. Moayedi¹, C. Fan², M. Tremblay-Gravel¹, R. J. Miller¹, M. Kawana¹, J. Parizo¹, G. Oro¹, R. Wainwright¹, H. I. Luikart¹, N. D'Emilio¹, J. Gordon¹, R. Kameda¹, M. Ikutomi¹, C. Manlhiot¹, W. F. Fearon¹, H. J. Ross¹, K. K. Khush¹, J. J. Teuteberg¹
¹Stanford University, Palo Alto, CA, ²University of Toronto, Toronto, ON, Canada
*Purpose: Cardiac allograft vasculopathy (CAV) is the “Achilles heel” of long-term survival after heart transplantation. While conventional coronary angiography is recognised as the standard for…
2019 American Transplant Congress
A Prognostic Drug Development Tool to Assess the Transplantability at the Time of Listing for Kidney Transplant Candidates
S. Kawakita¹, L. Hidalgo-Semlek², J. L. Beaumont¹, J. Lee², M. J. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²Hansa Medical AB, Lund, Sweden
*Purpose: At time of listing for kidney transplant (KT), a patient is not informed of the probabilities of KT, death, or remaining on the waiting…
2019 American Transplant Congress
External Validation of the Living Kidney Donor Profile Index (LKDPI) in the Canadian Kidney Transplant Recipient Population
M. Shantier¹, Y. Li¹, M. Ashwin¹, O. Famure¹, S. K. Singh²
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Department of Medicine, University of Toronto, Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: The LKDPI is a risk index which incorporates clinical characteristics of living kidney donors and their recipients to predict the risk of total graft…
2019 American Transplant Congress
Immunobiogram, a New IVD Immunoassay to Test the Sensitivity Profile of Kidney Transplant Recipients to Immunosuppressive Drugs: Further Results from BH-Pilot Study
C. Jimenez¹, J. M. Portoles², D. Blánquez³, L. Arribas³, A. Ortega⁴, T. Diez⁵, I. Portero⁶
¹Nephrology Department, La Paz Hospital, Madrid, Spain, ²Nephrology Department, Puerta de Hierro Mahadahonda Hospital, Madrid, Spain, ³Adamas Engineering Consulting, Madrid, Spain, ⁴I+D, Biohope, Madrid, Spain, ⁵Medical, Biohope, Madrid, Spain, ⁶CEO, Biohope, Madrid, Spain
*Purpose: IMBG is an immunoassay developed by Biohope to measure in vitro PBMC sensitivity/resistance profile to a panel of immunosuppressive drugs (IS) in Kidney Transplant…
2019 American Transplant Congress
Predicting HCC Recurrence Following Liver Transplant – A Machine Learning Approach
L. F. Lau¹, W. Nelson², A. Gorgen¹, L. Erdman², P. Abreu¹, A. Goldenberg², G. Sapisochin¹
¹Department of Surgery, University of Toronto, Toronto, ON, Canada, ²The Center for Computational Medicine, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: The liver transplant listing criteria for hepatocellular carcinoma (HCC) is controversial. Policies aim to prevent tumor recurrence but it has been difficult to encompass…
2019 American Transplant Congress
Pre-Transplant Ventricular Assist Device (VAD) Impacts Heart Transplant (HT) Survival
M. S. Gharibdousti¹, M. T. Khasawneh², A. L Friedman³
¹Research, LiveOnNY, Manhattan, NY, ²Binghamton University, Binghamton, NY, ³LiveOnNY, Manhattan, NY
*Purpose: Retrospective analysis of UNOS data was performed to determine regional variation in the utilization and impact of VAD prior to HT in the United…

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