Articles tagged "Prediction models"

2022 American Transplant Congress
Computer vs Human-Based Prediction and Stratification of the Risk of Long-Term Kidney Allograft Failure
G. Divard¹, M. Raynaud¹, V. Tataputii², B. Abdalla³, C. Legendre¹, C. Lefaucheur¹, O. Aubert¹, A. Loupy¹
¹Paris Transplant Group, Paris, France, ²NYU Langone Health, New York, NY, ³UCLA, Los Angeles, CA
*Purpose: Clinical decision-making process after transplantation is mainly driven by patient individual risk of allograft failure prediction assessed by physicians. However, this task remains difficult…
2022 American Transplant Congress
A Hybrid Model Combining Survival Analysis, Knapsack Optimization and Supervised Learning to Extrapolate the Evolution of Kidney Transplantation Patients from Donors with Expanded Criteria After Controlled Circulatory Death
F. Santos Arteaga¹, D. Di Caprio², O. Bestard³, N. Montero⁴, F. Moreso³, M. Crespo⁵, C. Facundo⁶, J. Reinoso-Moreno⁷, D. Cucchiari⁷, B. Bayes⁷, E. Poch⁷, J. M. Campistol⁷, F. Oppenheimer⁷, F. Diekmann⁷, I. Revuelta⁷
¹Faculty of Economics and Management, Universidad Complutense de Madrid, Madrid, Spain, ²Department of Economics and Management, University of Trento, Trento, Italy, ³Department of Nephrology and Kidney Transplant, Hospital Universitari Vall Hebrón, Barcelona, Spain, ⁴Department of Nephrology and Kidney Transplant, Hospital Universitari de Bellvitge, Barcelona, Spain, ⁵Department of Nephrology and Kidney Transplant, Hospital del Mar, Barcelona, Spain, ⁶Department of Nephrology and Kidney Transplant, Fundació Puigvert, Barcelona, Spain, ⁷Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain
*Purpose: Kidney transplantation (KT) with expanded criteria donors (ECD) after controlled circulatory death (cDCD) in high-risk patients is being debated. We categorize patients via a…
2022 American Transplant Congress
Dynamic Risk Prediction of Kidney Graft Failure After Deceased Donor Transplant
D. G. Hu¹, H. Thiessen Philbrook¹, S. Mohan², I. Hall³, M. Doshi⁴, K. F. Kerr⁵, C. R. Parikh¹
¹Johns Hopkins University, Baltimore, MD, ²Columbia University Medical Center, New York, NY, ³University of Utah, Salt Lake City, UT, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Washington, Seattle, WA
*Purpose: Identifying kidney transplant recipients at risk of graft failure allows for early intervention in clinical care. We developed a dynamic risk prediction model based…
2022 American Transplant Congress
Four Separate Frailty Metrics Lack Concordance and Are Non-Reflective of the Kidney Transplant Listing Outcome: A Large Single Center Review
A. Cimeno, G. Lewis, R. Parsons
Transplant Surgery, Emory University Hospital, Atlanta, GA
*Purpose: It is well known that functional status has prognostic value for post-surgical outcomes, however pre-transplant patients are not required to undergo objective frailty testing.…
2022 American Transplant Congress
Development of a Radiomics-Based Model to Predict Graft Fibrosis in Liver Transplant Recipients: A Pilot Study
F. Qazi Arisar¹, E. Salinas-Miranda², H. Ale Ali², K. Lajkosz³, C. Chen¹, A. Azhie¹, G. M. Healy², D. Deniffel², M. A. Haider², M. Bhat¹
¹Ajmera Transplant Program, University Health Network, Toronto, ON, Canada, ²Lunenfeld Tanenbaum Research Institute, Toronto, ON, Canada, ³Department of Biostatistics, University Health Network, Toronto, ON, Canada
*Purpose: Recurrent fibrosis complicates 40% of Liver transplants (LT), compromising long-term survival. We evaluated the ability of a model combining radiomic features on CT scans…
2022 American Transplant Congress
Factors Predicting Early Extubation After Liver Transplantation
V. Subramanian¹, O. Bishr², J. Buggs¹, N. Kemmer¹, K. Dhanireddy¹
¹Transplant Institute, Tampa General Hospital, Tampa, FL, ²University of South Florida, Tampa, FL
*Purpose: Early extubation (either intraoperative or within 6 hours post operatively) is an important component of enhanced recovery pathways. The goal of the study was…
2022 American Transplant Congress
Non-Invasive Metabolite-Based Urine Signature Detects Over-Immunosuppression in Renal Transplant Recipients
S. Raghavendra Rao¹, C. Honrao¹, L. O. Rodrigues¹, C. Dong¹, K. Sonkar¹, J. Wolf¹, E. M. O'Day¹, D. R. Kuypers²
¹Olaris, Inc., Framingham, MA, ²Department of Nephrology and Renal Transplantation, University Hospitals, Leuven, Belgium
*Purpose: Managing complications related to over-immunosuppression represents a growing challenge in post-transplant care, with infections accounting for the second leading cause of death with functioning…
2022 American Transplant Congress
Clinical Impact of a Modified Lung Allocation Score That Mitigates Selection Bias
E. M. Schnellinger¹, E. Cantu², D. E. Schaubel¹, S. E. Kimmel³, A. J. Stephens-Shields¹
¹University of Pennsylvania, Philadelphia, PA, ²Hospital of the University of Pennsylvania, Philadelphia, PA, ³University of Florida, Gainesville, FL
*Purpose: The U.S. lung allocation system uses the Lung Allocation Score (LAS) to prioritize lung transplant candidates. Selection bias, induced by dependent censoring of waitlisted…
2022 American Transplant Congress
Processing Personal Activity Tracker (PAT) Through Artificial Intelligence (AI) is a Promising Method to Identify Patterns of Physical Activity in Liver Transplant (LT) Candidates
A. Duarte-Rojo¹, P. M. Bloomer¹, J. M. Jakicic², E. Sejdic³
¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²Adventa Health, Orlando, FL, ³University of Pittsburgh, Pittsburgh, PA
*Purpose: Prehabilitation is recommended for frail and pre-frail LT candidates. Although home-based programs are generalizable, their success depends on the adherence to an exercise prescription.…
2022 American Transplant Congress
A Novel Prospective Validation Trial Of Multiple Blood-based RNA Signature Assays Pre And Post Kidney Transplant To Predict Rejection
L. Gallon¹, P. O'Connell², A. Chang³, M. Donovan⁴
¹Northwestern Univ, Chicago, IL, ²Westmead Inst, Sydney, Australia, ³Univ of Chicago, Chicago, IL, ⁴Verici Dx, Franklin, TN
*Purpose: The accuracy and utility of clinically defined and analytically validated predictive biomarkers in kidney transplantation is limited. We leveraged prior feasibility blood-RNA studies to…