Articles tagged "Prediction models"

2018 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
J. Assaker,¹ A. Srivastava,¹ J. Hurley,² B. Al Doujailan,¹ S. Eskandari,¹ C. Coticchia,² M. Mohamed,¹ S. Bentink,² V. Tadigotla,² L. Riella,¹ A. Chandraker,¹ J. Skog,² J. Azzi.¹
¹Transplantation Renal Center, BWH and BCH, Boston; ²Exosome Diagnostic Inc., Cambridge.
Kidney transplant rejection leads to short and long-term adverse clinical outcomes. Serum creatinine is a suboptimal late biomarker for rejection. Exosomes are nanometer-sized vesicles released…
2018 American Transplant Congress
Improving Prognostication amongst Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma: An International, 16-Center Study to Validate and Recalibrate HALTHCC
D. Firl,¹ K. Sasaki,¹ S. Kimura,² W. Dumronggittigule,³ A. Gorgen,⁴ J. Lerut,⁵ M. Rossi,⁶ U. Cillo,⁷ A. Viveiros,⁸ E. Tsochatzis,⁹ G. Otto,¹⁰ G. Ettorre,¹¹ G. Tisone,¹² M. Vivarelli,¹³ S. Agnes,¹⁴ J. Markmann,² T. Ikegami,¹⁵ T. Kaido,¹⁶ G. Sapisochin,⁴ V. Agopian,³ Q. Lai,^5,6 F. Aucejo.¹
¹CCF, Cleveland; ²MGH, Boston; ³UCLA, LA; ⁴UHN, Toronto, Canada; ⁵SLH, Louvain, Belgium; ⁶UH, Rome, Italy; ⁷UP, Padua, Italy; ⁸MUI, Innsbruck, Austria; ⁹UCL, London, United Kingdom; ¹⁰UM, Mainz, Germany; ¹¹SCH, Rome, Italy; ¹²TVU, Rome, Italy; ¹³AOU, Torrette Ancona, Italy; ¹⁴AGH, Rome, Italy; ¹⁵KU, Kyoto, Japan; ¹⁶KU, Kyushu, Japan.
Objective: Prognosticating outcomes in liver transplant (LT) for hepatocellular carcinoma (HCC) continues to challenge the field. Whereas adoption of the binary Milan Criteria (MC) generalized…
2018 American Transplant Congress
Elucidating Novel Signatures of Allograft Rejection through Cytometry by Time of Flight (CyTOF) in Kidney Transplant Recipients
S. Eskandari,¹ B. Al Dulaijan,¹ J. Assaker,¹ L. Riella,¹ A. Kurdi,² J. Azzi.¹
¹Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Mass cytometry by time-of-flight (CyTOF) permits the simultaneous assessment of over 40 functional and phenotypic parameters at the single-cell level. This novel tool holds tremendous…
2018 American Transplant Congress
The Utility of an Online Survival Calculator in Selecting Older Candidates for Kidney Transplantation
M. Shwetar, K. Abdel-Kader, B. Concepcion.
Vanderbilt University Medical Center, Nashville, TN.
Background: Older patients referred for kidney transplantation are medically complex. A posttransplant survival prediction model is publicly available online and may aid physicians in selecting…
2018 American Transplant Congress
Pre-Operative Predictors of Health-Related Quality of Life for Pancreas Transplant Recipients
I. Mosca,³ S. Mittal,¹ J. Smith,² P. Friend.^1,3
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom; ²Nuffield Department of Population Health, Health and Economics Research Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom; ³Oxford Transplant Centre, Oxford University NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom.
A) AimsThe aim of this study is to identify the relative importance of pre-operative recipient and donor factors as possible predictors of post-pancreas transplant health-related…
2018 American Transplant Congress
Prognostic Value and Biological Significances of Five Long Non-Coding RNAs in Hepatocellular Carcinoma
Y. Hou,¹ Z. Yu,² N. Tam,¹ S. Huang,¹ J. Yang,¹ L. Wu,¹ Y. Ma,¹ X. He.¹
¹Department of Organ Transplantation, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China; ²Laboratory of Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Objectives Increasing evidence suggests that long non-coding RNA (lncRNA) plays a vital role in metastasis and development in hepatocellular carcinoma (HCC). Tumor progression severely affect…
2018 American Transplant Congress
TP53 Mutations Lead to Increased Transcription of Circular RNAs in Exosomes Enhancing Tumor Invasiveness in Hepatocellular Carcinoma Bases on Bioinformatics Analysis
Z. Yu, Y. Hou, R. Wang, X. Huang.
The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Objective Increasing evidence suggests that cicular RNAs play an important role in tumor. A recent study found the enrichment of cicular RNAs in HCC derived…
2018 American Transplant Congress
A 5-Tier System for Categorizing Program-Specific Adjusted Transplant and Waitlist Mortality Rate Ratios
A. Wey, N. Salkowski, B. Kasiski, A. Israni, J. Snyder.
SRTR, Minneapolis.
SRTR may begin reporting tiers for program-specific transplant and waitlist mortality rate ratios. A 3-tier system based on statistical hypothesis testing has several deficiencies. Waitlist…
2018 American Transplant Congress
Heart and Lung Offer Acceptance Practices Are Associated with Organ Yield and Local Placement
A. Wey, M. Skeans, N. Salkowski, B. Kasiske, A. Israni, J. Snyder.
SRTR, Minneapolis.
Below average offer acceptance practices could delay placement of donor hearts and lungs and may ultimately lead to organ discard. Recovered thoracic organs are rarely…
2018 American Transplant Congress
A Machine Learning Approach for Prediction of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients
S. Kawakita,¹ A. Waterman,^1,2 M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Introduction:Delayed graft function (DGF) is an early signal of graft injury that is common in deceased donor kidney transplant (DDKT) recipients. Although we have predictive…