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Articles tagged "Post-transplant malignancy"

  • 2018 American Transplant Congress

    Different Expression Patterns of Exosomal miRNAs under Cyclosporin A and Rapamycin Treatment in Distinct Aggressiveness Colorectal Carcinomas

    V. Tubita,1 M. Ramírez-Bajo,1 J. Lozano,2 D. Moya-Rull,1 J. Rovira,3 J. Campistol,4,5,6 F. Diekmann,1,4,5,6 I. Revuelta.1,4,5,6

    1Experimental Laboratory of Nefrology and Kidney Transplant (LENIT). Biomedical Research Clinic Foundation (FCRB), Barcelona, Spain; 2Bioinformatics Platform, CIBEREHD, Barcelona, Spain; 3Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; 4Renal Transplant Unit. Department of Nephrology and Kidney Transplant. Hospital Clinic, Barcelona, Spain; 5REDinREN, Madrid, Spain; 6Barcelona University, Barcelona, Spain.

    The aggressiveness of colorectal cancer (CRC) in kidney transplantation is much more significant than the increase in its incidence compared with the general population. The…
  • 2018 American Transplant Congress

    Do We Need to Worry about EBV DNAemia in the Late Post-Transplant Period?

    M. Morton,1 K. Daga,2 P. Klapper,2 M. Picton,1 P. Vallely.2

    1Department of Renal Medicine, Manchester Royal Infirmary, Manchester, United Kingdom; 2University of Manchester, Manchester, United Kingdom.

    Background: Despite detectable Epstein-Barr virus (EBV) in blood, kidney transplant patients (KTR) may have no apparent clinical consequence. This study aims to explore the clinical…
  • 2018 American Transplant Congress

    Racial Differences in Rates of Malignant and Infectious Cutaneous Genital Disease after Solid Organ Transplantation

    M. Larijani,1 K. Nadhan,1 J. Abbott,1 A. Doyle,2 C. Chung.1

    1Department of Dermatology, Drexel University, Philadelphia, PA; 2Department of Internal Medicine, University of Virginia, Charlottesville, VA.

    Purpose: To describe the prevalence and types of genital lesions observed in OTRsMethods: This retrospective review included 496 OTRs who underwent full skin examination at…
  • 2018 American Transplant Congress

    Decreased Post Heart Transplant Survival with Epstein-Barr Virus Mismatch in the Current Era

    M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, S. Mersola, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Epstein-Barr virus (EBV) has been implicated in a multitude of cancers, including B-cell lymphoma, Burkitt's lymphoma, CNS lymphoma, gastric cancer and nasopharyngeal carcinoma. Previous…
  • 2018 American Transplant Congress

    Development of an Expert Consensus Guideline for Skin Cancer Screening in Solid Organ Transplant Recipients

    L. Crow,1 S. Arron,1 C. Chung,2 A. Jambusaria-Pahlajani,3 S. Lowenstein,1 On behalf of the Transplant Skin Cancer Network.

    1Dermatology, University of California San Francisco, San Francisco, CA; 2Dermatology, Drexel Medicine, Philadelphia, PA; 3Dermatology, Baylor, Scott & White Health, Round Rock, TX.

    Importance Skin cancer is the most common malignancy affecting solid organ transplant recipients (SOTR). Transplant recipients have a significantly increased risk for developing both melanoma…
  • 2018 American Transplant Congress

    Decreased Expression of Pro-Carcinogenic Genes Following Tacrolimus to Sirolimus Conversion in Liver Transplant Recipients

    M. Bhat,1 E. Pasini,1 C. Baciu,1 S. Kurian,2 J. Levitsky.3

    1Multi Organ Transplant Program, University Health Network, Toronto, Canada; 2Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA; 3Division of Gastroenterology & Hepatology, Department of Medicine, Northwestern University, Chicago.

    Long-term survival post-transplant is significantly impacted by malignancy. mTOR-inhibitors (mTORis) have anti-neoplastic properties and are associated with a decreased incidence of certain malignancies compared to…
  • 2018 American Transplant Congress

    Immunosuppression Does Not Affect Adverse Pathological Outcomes in Men Who Underwent Radical Prostatectomy

    M. Eltemamy, A. Elshafei, Y. Nyame, A. Crane, A. Wee, V. Krishnamurthi, E. Klein, S. Jones.

    Cleveland Clinic, Cleveland.

    Introduction: The impact of imuunosuppression (IS) on biological aggressiveness of cancer prostate (PCa) is unclear. We aim to assess the adverse pathological (AP) outcomes in…
  • 2018 American Transplant Congress

    Y-Adapter Mediated Next Gen Sequencing of BKPyV from Archived FFPE Tissue

    E. Harake,1 W. Wu,2 J. Opp,2 E. Farkash.1

    1Pathology, Michigan Medicine, Ann Arbor; 2Michigan Medicine, Ann Arbor.

    Background: In a subset of renal transplant recipients with urothelial carcinoma, tumor cells show universal expression of BK Polyomavirus (BKPyV) proteins, a hallmark of oncoviruses.…
  • 2018 American Transplant Congress

    Prostate Cancer Characteristics in Men on Immunosuppressive Medications

    M. Eltemamy, A. Elshafei, A. Salah, Y. Nyame, H. Arora, A. Wee, V. Krishnamurthi, S. Jones.

    Cleveland Clinic, Cleveland.

    INTRODUCTION: To assess the prevalence of prostate cancer (PCa) in men receiving immunosuppressive medications undergoing transrectal ultrasound guided (TRUS) prostate biopsy.METHODS: A total of 468…
  • 2017 American Transplant Congress

    BK Virus Infection and Risk of Urinary Tract Cancers Among Kidney Transplant Patients in the Transplant Cancer Match Study.

    G. Gupta,1 S. Kuppachi,2 R. Kalil,2 C. Buck,3 C. Lynch,2 E. Engels.3

    1Virginia Commonwealth University, Richmond; 2University of Iowa, Iowa City; 3National Cancer Institute, Bethesda

    Background: Recent case series describe expression of BK virus (BKV) in tumor tissue obtained from renourinary cancers in kidney transplant recipients (KTRs). Thus, BKV may…
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