Articles tagged "Post-transplant malignancy"

2018 American Transplant Congress
Outcomes of Organ Transplantation from Donors with Cancer History
Z. Guo,¹ X. He,¹ S. Huang.¹
¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Sun Yat-sen University, Guangzhou, China; ³Guangdong Provincial International Cooperation Base of Science and Technology, Sun Yat-sen University, Guangzhou, China.
Purpose: The inherent challenges of selecting an acceptable donor for each of the increasing numbers and acuity of recipients has led programs to take increased…
2018 American Transplant Congress
Organ Transplantation Associated with High Incidence of Anal Cancer and Pre-Cancer Lesions among HIV-Infected Women and Men
P. Chin-Hong,¹ B. Barin,² M. Berry,¹ M. DaCosta,¹ T. Darragh,¹ L. Rosenthal,³ S. Bartlett,⁴ D. Dieterich,⁵ F. Poordad,⁶ N. Nissen,⁶ M. Wong,⁷ P. Stock,¹ J. Palefsky.¹
¹University of California, San Francisco, San Francisco; ²EMMES, Rockville; ³Columbia University, New York; ⁴University of Maryland, Baltimore; ⁵Icahn School of Medicine at Mount Sinai, New York; ⁶Cedars-Sinai Medical Center, Los Angeles; ⁷Beth Israel Deaconess Medical Center, Boston.
Objective: HIV-infected women and men and transplant recipients are two populations at increased risk of HPV-associated anal cancer but there is little published data. We…
2018 American Transplant Congress
Different Expression Patterns of Exosomal miRNAs under Cyclosporin A and Rapamycin Treatment in Distinct Aggressiveness Colorectal Carcinomas
V. Tubita,¹ M. Ramírez-Bajo,¹ J. Lozano,² D. Moya-Rull,¹ J. Rovira,³ J. Campistol,^4,5,6 F. Diekmann,^1,4,5,6 I. Revuelta.^1,4,5,6
¹Experimental Laboratory of Nefrology and Kidney Transplant (LENIT). Biomedical Research Clinic Foundation (FCRB), Barcelona, Spain; ²Bioinformatics Platform, CIBEREHD, Barcelona, Spain; ³Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; ⁴Renal Transplant Unit. Department of Nephrology and Kidney Transplant. Hospital Clinic, Barcelona, Spain; ⁵REDinREN, Madrid, Spain; ⁶Barcelona University, Barcelona, Spain.
The aggressiveness of colorectal cancer (CRC) in kidney transplantation is much more significant than the increase in its incidence compared with the general population. The…
2018 American Transplant Congress
Do We Need to Worry about EBV DNAemia in the Late Post-Transplant Period?
M. Morton,¹ K. Daga,² P. Klapper,² M. Picton,¹ P. Vallely.²
¹Department of Renal Medicine, Manchester Royal Infirmary, Manchester, United Kingdom; ²University of Manchester, Manchester, United Kingdom.
Background: Despite detectable Epstein-Barr virus (EBV) in blood, kidney transplant patients (KTR) may have no apparent clinical consequence. This study aims to explore the clinical…
2018 American Transplant Congress
Racial Differences in Rates of Malignant and Infectious Cutaneous Genital Disease after Solid Organ Transplantation
M. Larijani,¹ K. Nadhan,¹ J. Abbott,¹ A. Doyle,² C. Chung.¹
¹Department of Dermatology, Drexel University, Philadelphia, PA; ²Department of Internal Medicine, University of Virginia, Charlottesville, VA.
Purpose: To describe the prevalence and types of genital lesions observed in OTRsMethods: This retrospective review included 496 OTRs who underwent full skin examination at…
2018 American Transplant Congress
Decreased Post Heart Transplant Survival with Epstein-Barr Virus Mismatch in the Current Era
M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, S. Mersola, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Epstein-Barr virus (EBV) has been implicated in a multitude of cancers, including B-cell lymphoma, Burkitt's lymphoma, CNS lymphoma, gastric cancer and nasopharyngeal carcinoma. Previous…
2018 American Transplant Congress
Development of an Expert Consensus Guideline for Skin Cancer Screening in Solid Organ Transplant Recipients
L. Crow,¹ S. Arron,¹ C. Chung,² A. Jambusaria-Pahlajani,³ S. Lowenstein,¹ On behalf of the Transplant Skin Cancer Network.
¹Dermatology, University of California San Francisco, San Francisco, CA; ²Dermatology, Drexel Medicine, Philadelphia, PA; ³Dermatology, Baylor, Scott & White Health, Round Rock, TX.
Importance Skin cancer is the most common malignancy affecting solid organ transplant recipients (SOTR). Transplant recipients have a significantly increased risk for developing both melanoma…
2018 American Transplant Congress
Decreased Expression of Pro-Carcinogenic Genes Following Tacrolimus to Sirolimus Conversion in Liver Transplant Recipients
M. Bhat,¹ E. Pasini,¹ C. Baciu,¹ S. Kurian,² J. Levitsky.³
¹Multi Organ Transplant Program, University Health Network, Toronto, Canada; ²Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA; ³Division of Gastroenterology & Hepatology, Department of Medicine, Northwestern University, Chicago.
Long-term survival post-transplant is significantly impacted by malignancy. mTOR-inhibitors (mTORis) have anti-neoplastic properties and are associated with a decreased incidence of certain malignancies compared to…
2018 American Transplant Congress
Immunosuppression Does Not Affect Adverse Pathological Outcomes in Men Who Underwent Radical Prostatectomy
M. Eltemamy, A. Elshafei, Y. Nyame, A. Crane, A. Wee, V. Krishnamurthi, E. Klein, S. Jones.
Cleveland Clinic, Cleveland.
Introduction: The impact of imuunosuppression (IS) on biological aggressiveness of cancer prostate (PCa) is unclear. We aim to assess the adverse pathological (AP) outcomes in…
2017 American Transplant Congress
Donor Derived and BK Virus Positive Urologic Cancers After Renal Transplantation.
V. Hellström,¹ G. Tufveson,¹ A. Wallgren,² A. Loskog,² E. Larsson,² T. Töttermann,² M. Bengtsson,² A. Laurell,² C. Lundberg,¹ B. Holmström,¹ G. Enblad,² T. Lorant.¹
¹Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; ²Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Background. Donor-derived tumours in organ recipients develop from donor tissue with no known pre-existing malignancy in the donor. In addition, polyoma BK virus (BKV) might…