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Articles tagged "Post-transplant malignancy"

  • 2018 American Transplant Congress

    Development of an Expert Consensus Guideline for Skin Cancer Screening in Solid Organ Transplant Recipients

    L. Crow,1 S. Arron,1 C. Chung,2 A. Jambusaria-Pahlajani,3 S. Lowenstein,1 On behalf of the Transplant Skin Cancer Network.

    1Dermatology, University of California San Francisco, San Francisco, CA; 2Dermatology, Drexel Medicine, Philadelphia, PA; 3Dermatology, Baylor, Scott & White Health, Round Rock, TX.

    Importance Skin cancer is the most common malignancy affecting solid organ transplant recipients (SOTR). Transplant recipients have a significantly increased risk for developing both melanoma…
  • 2018 American Transplant Congress

    Decreased Expression of Pro-Carcinogenic Genes Following Tacrolimus to Sirolimus Conversion in Liver Transplant Recipients

    M. Bhat,1 E. Pasini,1 C. Baciu,1 S. Kurian,2 J. Levitsky.3

    1Multi Organ Transplant Program, University Health Network, Toronto, Canada; 2Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA; 3Division of Gastroenterology & Hepatology, Department of Medicine, Northwestern University, Chicago.

    Long-term survival post-transplant is significantly impacted by malignancy. mTOR-inhibitors (mTORis) have anti-neoplastic properties and are associated with a decreased incidence of certain malignancies compared to…
  • 2018 American Transplant Congress

    Immunosuppression Does Not Affect Adverse Pathological Outcomes in Men Who Underwent Radical Prostatectomy

    M. Eltemamy, A. Elshafei, Y. Nyame, A. Crane, A. Wee, V. Krishnamurthi, E. Klein, S. Jones.

    Cleveland Clinic, Cleveland.

    Introduction: The impact of imuunosuppression (IS) on biological aggressiveness of cancer prostate (PCa) is unclear. We aim to assess the adverse pathological (AP) outcomes in…
  • 2018 American Transplant Congress

    Y-Adapter Mediated Next Gen Sequencing of BKPyV from Archived FFPE Tissue

    E. Harake,1 W. Wu,2 J. Opp,2 E. Farkash.1

    1Pathology, Michigan Medicine, Ann Arbor; 2Michigan Medicine, Ann Arbor.

    Background: In a subset of renal transplant recipients with urothelial carcinoma, tumor cells show universal expression of BK Polyomavirus (BKPyV) proteins, a hallmark of oncoviruses.…
  • 2018 American Transplant Congress

    Prostate Cancer Characteristics in Men on Immunosuppressive Medications

    M. Eltemamy, A. Elshafei, A. Salah, Y. Nyame, H. Arora, A. Wee, V. Krishnamurthi, S. Jones.

    Cleveland Clinic, Cleveland.

    INTRODUCTION: To assess the prevalence of prostate cancer (PCa) in men receiving immunosuppressive medications undergoing transrectal ultrasound guided (TRUS) prostate biopsy.METHODS: A total of 468…
  • 2018 American Transplant Congress

    Donor Derived Renal Cell Carcinoma (RCC) Transmission Events 2008-2016: A Report of the OPTN Disease Transmission Advisory Committee (DTAC)

    M. Pavlakis, M. Michaels, S. Tlusty, N. Turgeon, G. Vece, C. Wolfe, R. Wood, M. Nalesnik.

    OPTN/UNOS, RCC Work Group.

    Background: RCC is the most common renal tumor reported to the OPTN and reviewed by DTAC for assessment of potential donor transmission. Organs with concern…
  • 2018 American Transplant Congress

    Induction Agents and Post-Transplant Malignancies in Kidney Transplants: An Examination of Outcomes at a Large Volume Center over 20 Years

    D. Livingston-Rosanoff, X. Wang, G. Leverson, D. Kaufman, D. Foley.

    Division of Transplant Surgery, University of Wisconsin, Madison, WI.

    Introduction: Induction agents have a profound effect on the immune milieu at the time of kidney transplantation. However, evaluation of their long-term effects on graft…
  • 2018 American Transplant Congress

    The Influence of a Conversion to Sirolimus-Based Immunosuppression on Non-Melanomatous Skin Cancer Incidence in Kidney Transplant Recipients over Long Term Follow Up

    F. Daly,1 P. O'Kelly,1 F. Moloney,2 D. Sexton,1 P. Conlon.1

    1Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland; 2Department of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland.

    Background: The CONVERT trial found a reduced incidence of malignancy amongst renal transplant recipients over 2 years of follow up with a conversion from calcineurin…
  • 2018 American Transplant Congress

    Outcomes of Organ Transplantation from Donors with Cancer History

    Z. Guo,1 X. He,1 S. Huang.1

    1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; 2Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Sun Yat-sen University, Guangzhou, China; 3Guangdong Provincial International Cooperation Base of Science and Technology, Sun Yat-sen University, Guangzhou, China.

    Purpose: The inherent challenges of selecting an acceptable donor for each of the increasing numbers and acuity of recipients has led programs to take increased…
  • 2017 American Transplant Congress

    BK Virus Infection and Risk of Urinary Tract Cancers Among Kidney Transplant Patients in the Transplant Cancer Match Study.

    G. Gupta,1 S. Kuppachi,2 R. Kalil,2 C. Buck,3 C. Lynch,2 E. Engels.3

    1Virginia Commonwealth University, Richmond; 2University of Iowa, Iowa City; 3National Cancer Institute, Bethesda

    Background: Recent case series describe expression of BK virus (BKV) in tumor tissue obtained from renourinary cancers in kidney transplant recipients (KTRs). Thus, BKV may…
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