ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Pharmacokinetics"

  • 2019 American Transplant Congress

    Pharmacokinetics of Innovative versus Generic Valganciclovir in Kidney Transplant Recipients

    I. Parra-Avila1, A. Cohen-Bucay1, J. Alberu2, G. Castañeda-Hernandez3, L. E. Morales-Buenrostro1

    1Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición, Ciudad de Mexico, Mexico, 2Transplant, Instituto Nacional de Ciencias Médicas y Nutrición, Ciudad de Mexico, Mexico, 3Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de Mexico, Mexico

    *Purpose: In kidney transplant recipients (KTR), cytomegalovirus (CMV) is a common viral infection associated with significant morbidity and mortality. In the absence of prophylaxis, CMV…
  • 2019 American Transplant Congress

    Drug Metabolizing Capacity Of The Liver In Liver Donors Recovers Fully By One Month Post Donation

    M. Miah1, X. Wu1, I. H. Shaik1, H. J. Johnson1, S. Ganesh2, M. Molinari2, A. D. Tevar2, C. Hughes2, A. Humar2, R. Venkataramanan1

    1Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, 2Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: In liver donors, hepatic volume recovers to pre donation values in 2-6 months after surgery. However, there is limited information on the recovery of…
  • 2019 American Transplant Congress

    Efficacy And Safety Of Febuxostat In Renal Transplant Recipients With Hyperuricemia

    L. Liu1, J. Jiang1, Q. Fu2, S. Long3, H. Zhang2, X. Su2, J. Li2, C. Wu2, R. Deng2, W. Zhang3, C. Wang2

    1Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2Organ transplant center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 3Information Data Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    *Purpose: To assess the efficacy and safety of febuxostat in the treatment of hyperuricemia in renal transplant recipients.*Methods: A total number of 124 renal transplant…
  • 2019 American Transplant Congress

    The Reduced Tacrolimus Metabolism Rate and Its Association with Estimated Glomerular Filtration Rate and Interstitial Fibrosis: A Study Using Korean Organ Transplantation Registry (KOTRY) Dataset

    J. Jeong1, H. Ro2, T. Koo3, J. Yang3, M. Kim4, S. Shin5, J. Park6, T. Ban7, S. Han8, T. Kim9, C. Ahn10

    1Ajou University School of Medicine, Suwon, Korea, Republic of, 2Gachon University, Incheon, Korea, Republic of, 3Seoul National University Hospital, Seoul, Korea, Republic of, 4Yonsei University College of Medicine, Seoul, Korea, Republic of, 5Asan Medical Center, Seoul, Korea, Republic of, 6Samsung Medical Center, Seoul, Korea, Republic of, 7Seoul St Mary's Hospital, Seoul, Korea, Republic of, 8Keimyung University School of Medicine, Daegu, Korea, Republic of, 9Inje University, Busan Paik Hospital, Busan, Korea, Republic of, 10Seoul National University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Tacrolimus is the key drug in clinical transplant, which has narrow therapeutic index. A few studies reported the association of tacrolimus metabolism rate with…
  • 2019 American Transplant Congress

    Evaluation of Mycophenolate Mofetil Exposure in Renal Transplant Recipients

    M. C. Ott1, S. Mietz2, S. Chang3

    1Department of Pharmaceutical Services, Erie County Medical Center, Buffalo, NY, 2Department of Pharmacy, Indiana University Health, Indianapolis, IN, 3Department of Medicine, Jacobs School of Medicine & Biomedical Sciencess, Buffalo, NY

    *Purpose: Mycophenolate mofetil (MMF) is the most commonly prescribed immunosuppressant following transplantation in the United States. However, the occurrence of MMF therapy-related adverse events including…
  • 2019 American Transplant Congress

    Retrospective Nested Case Control Study of the Impact of Immunosuppression on Post Transplant Malignancy among Adult Heart Transplant Patients

    S. Crow, R. J. Bubik, S. S. Kushwaha, K. C. Mara, R. A. Dierkhising, N. L. Pereira

    Mayo Clinic, Rochester, MN

    *Purpose: Post-transplant malignancy is diagnosed in approximately 18% of heart transplant (HTx) recipients and is a leading long-term cause of death among these patients. The…
  • 2019 American Transplant Congress

    Development and Validation of a Capillary Blood Mitra-Based Assay for the Quantitative Determination of Advagraf® Concentrations in Transplant Patients

    N. Undre1, I. Dawson2, V. Aluvihare3, N. Kamar4, F. Saliba5, N. Torpey6, S. Anaokar7, G. Kazeem1

    1Astellas Pharma Europe Ltd, Chertsey, United Kingdom, 2Covance Laboratories, Harrogate, United Kingdom, 3Kings College Hospital, London, United Kingdom, 4CHU Rangueil, Toulouse, France, 5Hôpital Paul-Brousse, Villejuif, France, 6Addenbrookes Hospital, Cambridge, United Kingdom, 7Astellas Pharma Europe Ltd, Surrey, United Kingdom

    *Purpose: Therapeutic drug monitoring of tacrolimus (TAC) requires venepuncture blood samples taken by specialists, requiring patients to attend an outpatient clinic; this can be inconvenient…
  • 2019 American Transplant Congress

    The Comparative Safety and Efficacy of Direct Acting Oral Anticoagulants Relative to Warfarin Following Liver Transplantation

    A. Santeusanio, A. Weinberg, T. Schiano

    Mount Sinai Hospital, New York, NY

    *Purpose: This study describes the comparative safety and efficacy of direct acting oral anticoagulants (DOACs) relative to warfarin following liver transplantation, at a large academic…
  • 2019 American Transplant Congress

    Impact of Liver Recipient Genotype on Tacrolimus

    S. Tremblay1, T. Fukuda2, T. Mizuno2, A. A. Vinks2, E. Woodle1, J. Klawitter3, J. Klawitter3, U. Christians3, R. R. Alloway1

    1University of Cincinnati, Cincinnati, OH, 2Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, 3iC42 Clinical Research and Development, Aurora, CO

    *Purpose: In kidney transplant recipients, recipient genotype (CYP3A5 *3) has the greatest influence on tacrolimus pharmacokinetics (PK). However, in liver transplant recipient, donor liver and…
  • 2019 American Transplant Congress

    A Clinical Pharmacogenetic Model to Predict the Efficacy of Sirolimus during the Early Administration in Renal Transplant Recipients

    Z. Wang, S. Fei, Z. Han, J. Tao, R. Tan, M. Gu

    No.300 Guangzhou Road of Nanjing, Nanjing, China

    *Purpose: This study was to develop a clinical pharmacogenetic model to predict the efficacy of sirolimus during the early administration in renal transplant recipients. 70…
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