Articles tagged "Pharmacokinetics"

2015 American Transplant Congress
New Insights in Clinical and Genetic Determinants of Longitudinal Dose-Corrected CNI Exposure in Children After Renal Transplantation
N. Knops,¹ M. van Dyck,¹ E. Levtchenko,¹ D. Kuypers,² J. Herman.¹
¹Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
Purpose: Calcineurin-inhibitors (CNI) have a narrow therapeutic index and dosing is difficult due to inter- and intra-individual variation in pharmacokinetics (PK). Polymorphisms in genes involved…