ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Pharmacokinetics"

  • 2022 American Transplant Congress

    Effect of Schisandra Sphenanthera Extract on Pharmacokinetics of Tacrolimus in Pediatric Renal Transplant Recipients

    J. Jiang1, H. Zhang1, X. Su1, S. Wu1, Y. Chen2, W. Chen2, J. Li2, C. Wu2, L. Yang2, L. Liu2, C. Wang2

    1Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    *Purpose: Wuzhi tablet (Schisandra sphenanthera extract) is a promising tacrolimus-sparing agent in adult renal transplant recipients, while its effect in pediatric recipients remains unclear. The…
  • 2022 American Transplant Congress

    Tacrolimus Metabolizer Heterogeneity within Caucasian Kidney Transplant (KT) Recipients

    J. Sanchez-Garcia1, N. Oliver1, D. Morris1, A. Raza1, L. Lindberg1, S. LeCorhick1, T. Srinivas2, S. Anand1

    1Intermountain Medical Center, Murray, UT, 2CareDX, South San Francisco, CA

    *Purpose: Weight-based tacrolimus (T) dosing is the standard in post-transplant KT. African-Americans and Caucasians differ in their metabolizer phenotype for T. However, two morphometrically similar…
  • 2022 American Transplant Congress

    Phenytoin To Expedite Sirolimus & Tacrolimus Elimination: A Case Report

    A. Lemke, B. A. Boilson, R. Razonable, S. A. Bernard

    Mayo Clinic, Rochester, MN

    *Purpose: Sirolimus (SIR), a mammalian target of rapamycin inhibitor (mTORi), may be used with or without a calcineurin inhibitor after heart transplant (HT). The anti-proliferative…
  • 2022 American Transplant Congress

    Therapeutic Drug Monitoring of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Patients

    S. Sial, K. Cunningham, J. Moore, C. Dagostino, K. Lang, C. Kane

    Northwestern Memorial Hospital, Chicago, IL

    *Purpose: Lung transplant patients are at an increased risk for invasive fungal infections and often require prophylaxis post-transplant, routinely including posaconazole at our institution. These…
  • 2022 American Transplant Congress

    Induction of Tacrolimus Clearance by Steroids Varies by Cyp3a5 Genotype in Kidney Transplant Recipients: A Drug-Drug-Gene Interaction

    P. A. Jacobson1, A. Saqr1, M. Al-Kofahi1, D. P. Schladt2, W. Guan3, W. S. Oetting1, R. Mannon4, C. R. Dorr5, R. P. Remmel1, G. C. Onyeaghala6, B. Wu3, A. K. Israni7, A. Matas8

    1Univ of MN, College of Pharmacy, Minneapolis, MN, 2Hennepin Health Research Institute, Minneapolis, MN, 3Univ of MN, Biostatistics, Minneapolis, MN, 4Univ of Nebraska, Dept of Medicine, Omaha, NE, 5Hennepin Health Research Institute and Dept of Medicine, Minneapolis, MN, 6Hennepin Healthcare Research Institute, Minneapolis, MN, 7Hennepin Health Dept of Medicine and Univ of MN, Minneapolis, MN, 8University of MN, Dept of Surgery, Minneapolis, MN

    *Purpose: Tacrolimus (TAC) is the primary immunosuppressant used in organ transplantation. TAC is a substrate for CYP3A4/5. These enzymes are inhibited or induced by multiple…
  • 2022 American Transplant Congress

    No Grapefruit Juice Interaction with Tacrolimus LCP in Kidney Transplant Recipients

    J. Kerr1, Y. Sepulveda2, M. Shah3, A. Khan4, J. D. Momper2, S. Tsunoda2

    1Center for Transplantation, UC San Diego Health, San Diego, CA, 2UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA, 3Nephrology, UC San Diego Health, San Diego, CA, 4UCSD Center for Transplantation, San Diego, CA

    *Purpose: It is well known that grapefruit juice (GFJ) interacts with many medications through an intestinal CYP3A-mediated interaction that does not involve hepatic CYP3A and…
  • 2022 American Transplant Congress

    Tacrolimus Exposure Estimation in Stable Kidney Transplant Recipients Using Maximum A Posteriori Bayesian Approach

    T. Nguyen1, N. M. Smith1, K. Attwood2, B. Murray3, K. Tornatore-Morse1

    1University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, 2School of Public Health; University at Buffalo, Buffalo, NY, 3Erie County Medical Center; School of Medicine/UB, Buffalo, NY

    *Purpose: Tacrolimus exhibits interpatient pharmacokinetic variability that impacts clinical responses and requires routine trough therapeutic drug monitoring. Tacrolimus troughs do not consistently predict area under…
  • 2022 American Transplant Congress

    Reduced Enterohepatic Recirculation of Mycophenolate and Lower Blood Concentrations Are Associated with the Stool Bacterial Microbiome

    P. A. Jacobson1, A. Saqr1, B. Carlson1, C. Staley2, A. Rashidi3, S. Holtan3, M. Al-Kofahi1, T. Kaiser2, M. MacMillan4, J. Young5, N. El Jurdi3, D. Weisdorf3, A. Khoruts6

    1Univ of MN, College of Pharmacy, Minneapolis, MN, 2Univ of MN, Dept of Surgery, Minneapolis, MN, 3Univ of MN, Divison of Heme/Onc Transplant, Minneapolis, MN, 4Univ of MN, Pediatric Heme/Onc Transplant, Minneapolis, MN, 5Univ of MN, Divison of Infectious Diseases, Minneapolis, MN, 6Univ of MN, Division of Gastroenterology, Hepatology and Nutrition, Minneapolis, MN

    *Purpose: Mycophenolate mofetil (MMF) is an important immunosuppressant used after allogeneic hematopoietic cell transplant (HCT). Blood concentrations of mycophenolic acid (MPA) are highly variable and…
  • 2022 American Transplant Congress

    Impact of Cyp 3a5 Genotype on Lcp Tacrolimus Dosing and Monitoring in Kidney Transplantation

    D. J. Taber, T. Carcella, N. Patel, F. Bartlett, A. Posadas, V. Rao, M. Casey, V. Rohan, D. Dubay, D. Taber

    Med Univ of South Carolina, Charleston, SC

    *Purpose: LCP Tacrolimus has a recommended de novo starting dose of 0.14 mg/kg/day in kidney transplantation (KTR). There is limited data on the influence of…
  • 2022 American Transplant Congress

    The Impact of Tacrolimus Trough Variability on Acute Rejection Following Lung Transplantation

    K. Evans1, K. Beermann1, H. Lee2, M. Harris1, C. W. Frankel3, H. Berry1, H. Ali3

    1Pharmacy, Duke Health, Durham, NC, 2Biostatistics and Bioinformatics, Duke University, Durham, NC, 3Pulmonary, Allergy, and Critical Care, Duke Health, Durham, NC

    *Purpose: This study aimed to evaluate the association of tacrolimus coefficient of variation (CV) with biopsy-proven acute cellular rejection in the first year following lung…
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