2022 American Transplant Congress
Conversion from Immediate to Extended-Release Tacrolimus (LCP-Tac) Six Months After Renal Transplantation Optimizes Safety and Efficacy
*Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for prevention of rejection in kidney transplant recipients (KTRs) that may have less variability and…2022 American Transplant Congress
Impact of African American Race on Lcp-Tac Dosing and Clinical Outcomes
Medical University of South Carolina, Charleston, SC
*Purpose: The goal of this study was to assess the impact of African American (AA) race on the conversion ratio from Tac-IR to LCP-Tac, while…2022 American Transplant Congress
Effectiveness and Limitations of PK Analysis in Optimization of Immunosuppressive Therapy for Kidney Transplantation
Division of Kidney Transplantation, Department of Surgery, Aichi Medical University, Nagakute, Japan
*Purpose: In recent years, significant improvement in organ transplant outcomes have been achieved by using multidrug therapy with several immune monitoring, but the complexity of…2022 American Transplant Congress
Effect of Schisandra Sphenanthera Extract on Pharmacokinetics of Tacrolimus in Pediatric Renal Transplant Recipients
*Purpose: Wuzhi tablet (Schisandra sphenanthera extract) is a promising tacrolimus-sparing agent in adult renal transplant recipients, while its effect in pediatric recipients remains unclear. The…2022 American Transplant Congress
Tacrolimus Metabolizer Heterogeneity within Caucasian Kidney Transplant (KT) Recipients
1Intermountain Medical Center, Murray, UT, 2CareDX, South San Francisco, CA
*Purpose: Weight-based tacrolimus (T) dosing is the standard in post-transplant KT. African-Americans and Caucasians differ in their metabolizer phenotype for T. However, two morphometrically similar…2022 American Transplant Congress
Phenytoin To Expedite Sirolimus & Tacrolimus Elimination: A Case Report
*Purpose: Sirolimus (SIR), a mammalian target of rapamycin inhibitor (mTORi), may be used with or without a calcineurin inhibitor after heart transplant (HT). The anti-proliferative…2022 American Transplant Congress
Therapeutic Drug Monitoring of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Patients
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Lung transplant patients are at an increased risk for invasive fungal infections and often require prophylaxis post-transplant, routinely including posaconazole at our institution. These…2022 American Transplant Congress
Induction of Tacrolimus Clearance by Steroids Varies by Cyp3a5 Genotype in Kidney Transplant Recipients: A Drug-Drug-Gene Interaction
*Purpose: Tacrolimus (TAC) is the primary immunosuppressant used in organ transplantation. TAC is a substrate for CYP3A4/5. These enzymes are inhibited or induced by multiple…2022 American Transplant Congress
No Grapefruit Juice Interaction with Tacrolimus LCP in Kidney Transplant Recipients
*Purpose: It is well known that grapefruit juice (GFJ) interacts with many medications through an intestinal CYP3A-mediated interaction that does not involve hepatic CYP3A and…2022 American Transplant Congress
Tacrolimus Exposure Estimation in Stable Kidney Transplant Recipients Using Maximum A Posteriori Bayesian Approach
*Purpose: Tacrolimus exhibits interpatient pharmacokinetic variability that impacts clinical responses and requires routine trough therapeutic drug monitoring. Tacrolimus troughs do not consistently predict area under…
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