Articles tagged "Pharmacokinetics"

2022 American Transplant Congress
Induction of Tacrolimus Clearance by Steroids Varies by Cyp3a5 Genotype in Kidney Transplant Recipients: A Drug-Drug-Gene Interaction
P. A. Jacobson¹, A. Saqr¹, M. Al-Kofahi¹, D. P. Schladt², W. Guan³, W. S. Oetting¹, R. Mannon⁴, C. R. Dorr⁵, R. P. Remmel¹, G. C. Onyeaghala⁶, B. Wu³, A. K. Israni⁷, A. Matas⁸
¹Univ of MN, College of Pharmacy, Minneapolis, MN, ²Hennepin Health Research Institute, Minneapolis, MN, ³Univ of MN, Biostatistics, Minneapolis, MN, ⁴Univ of Nebraska, Dept of Medicine, Omaha, NE, ⁵Hennepin Health Research Institute and Dept of Medicine, Minneapolis, MN, ⁶Hennepin Healthcare Research Institute, Minneapolis, MN, ⁷Hennepin Health Dept of Medicine and Univ of MN, Minneapolis, MN, ⁸University of MN, Dept of Surgery, Minneapolis, MN
*Purpose: Tacrolimus (TAC) is the primary immunosuppressant used in organ transplantation. TAC is a substrate for CYP3A4/5. These enzymes are inhibited or induced by multiple…
2022 American Transplant Congress
No Grapefruit Juice Interaction with Tacrolimus LCP in Kidney Transplant Recipients
J. Kerr¹, Y. Sepulveda², M. Shah³, A. Khan⁴, J. D. Momper², S. Tsunoda²
¹Center for Transplantation, UC San Diego Health, San Diego, CA, ²UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA, ³Nephrology, UC San Diego Health, San Diego, CA, ⁴UCSD Center for Transplantation, San Diego, CA
*Purpose: It is well known that grapefruit juice (GFJ) interacts with many medications through an intestinal CYP3A-mediated interaction that does not involve hepatic CYP3A and…
2022 American Transplant Congress
Tacrolimus Exposure Estimation in Stable Kidney Transplant Recipients Using Maximum A Posteriori Bayesian Approach
T. Nguyen¹, N. M. Smith¹, K. Attwood², B. Murray³, K. Tornatore-Morse¹
¹University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, ²School of Public Health; University at Buffalo, Buffalo, NY, ³Erie County Medical Center; School of Medicine/UB, Buffalo, NY
*Purpose: Tacrolimus exhibits interpatient pharmacokinetic variability that impacts clinical responses and requires routine trough therapeutic drug monitoring. Tacrolimus troughs do not consistently predict area under…
2022 American Transplant Congress
Reduced Enterohepatic Recirculation of Mycophenolate and Lower Blood Concentrations Are Associated with the Stool Bacterial Microbiome
P. A. Jacobson¹, A. Saqr¹, B. Carlson¹, C. Staley², A. Rashidi³, S. Holtan³, M. Al-Kofahi¹, T. Kaiser², M. MacMillan⁴, J. Young⁵, N. El Jurdi³, D. Weisdorf³, A. Khoruts⁶
¹Univ of MN, College of Pharmacy, Minneapolis, MN, ²Univ of MN, Dept of Surgery, Minneapolis, MN, ³Univ of MN, Divison of Heme/Onc Transplant, Minneapolis, MN, ⁴Univ of MN, Pediatric Heme/Onc Transplant, Minneapolis, MN, ⁵Univ of MN, Divison of Infectious Diseases, Minneapolis, MN, ⁶Univ of MN, Division of Gastroenterology, Hepatology and Nutrition, Minneapolis, MN
*Purpose: Mycophenolate mofetil (MMF) is an important immunosuppressant used after allogeneic hematopoietic cell transplant (HCT). Blood concentrations of mycophenolic acid (MPA) are highly variable and…
2022 American Transplant Congress
Impact of Cyp 3a5 Genotype on Lcp Tacrolimus Dosing and Monitoring in Kidney Transplantation
D. J. Taber, T. Carcella, N. Patel, F. Bartlett, A. Posadas, V. Rao, M. Casey, V. Rohan, D. Dubay, D. Taber
Med Univ of South Carolina, Charleston, SC
*Purpose: LCP Tacrolimus has a recommended de novo starting dose of 0.14 mg/kg/day in kidney transplantation (KTR). There is limited data on the influence of…
2022 American Transplant Congress
The Impact of Tacrolimus Trough Variability on Acute Rejection Following Lung Transplantation
K. Evans¹, K. Beermann¹, H. Lee², M. Harris¹, C. W. Frankel³, H. Berry¹, H. Ali³
¹Pharmacy, Duke Health, Durham, NC, ²Biostatistics and Bioinformatics, Duke University, Durham, NC, ³Pulmonary, Allergy, and Critical Care, Duke Health, Durham, NC
*Purpose: This study aimed to evaluate the association of tacrolimus coefficient of variation (CV) with biopsy-proven acute cellular rejection in the first year following lung…
2022 American Transplant Congress
Predicted Performance of Bayesian-Based Precision Dosing Software for Tacrolimus
A. Seghezzo¹, J. Kerr¹, A. Gupta², A. Ta², L. Powell², A. Feist³
¹University of California San Diego Health, San Diego, CA, ²PrecisePK, San Diego, CA, ³UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA
*Purpose: Bayesian-based precision dosing software (BPDS) has been utilized for therapeutic drug monitoring to optimize medication use. However, BPDS for tacrolimus (TAC) is not routinely…
2022 American Transplant Congress
Evaluation of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Recipients
R. Gordon¹, K. Dewey¹, R. Jariwala¹, B. Yen¹, J. Kukreja², S. Hays², J. Singer², R. Florez¹
¹Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, ²University of California, San Francisco, San Francisco, CA
*Purpose: We hypothesized that crushed posaconazole delayed release (POSA DR) tablets can reach therapeutic levels in lung transplant recipients who are at risk for invasive…
2022 American Transplant Congress
Conversion from Immediate to Extended-Release Tacrolimus (LCP-Tac) Six Months After Renal Transplantation Optimizes Safety and Efficacy
S. P. Patel, F. Bartlett, T. Sprague, J. Newman, E. Andrade, N. Rao, N. Patel, D. Dubay, V. Rohan, M. Casey, D. Taber
MUSC Health, Charleston, SC
*Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for prevention of rejection in kidney transplant recipients (KTRs) that may have less variability and…
2022 American Transplant Congress
Impact of African American Race on Lcp-Tac Dosing and Clinical Outcomes
T. Sprague, F. Bartlett, J. Newman, S. Patel, N. Rao, E. Andrande, V. Rohan, D. Dubay, M. Casey, D. Taber
Medical University of South Carolina, Charleston, SC
*Purpose: The goal of this study was to assess the impact of African American (AA) race on the conversion ratio from Tac-IR to LCP-Tac, while…

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