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Articles tagged "Perfusion solutions"

  • 2018 American Transplant Congress

    EVLP on Donor Lungs: National Trends and Outcomes

    R. Lehman,1 R. Carrico,1 K. Uccellini,1 K. Chan,2 T. Whelan.3

    1United Network for Organ Sharing, Richmond, VA; 2Univ of Michigan, Ann Arbor, MI; 3Medical Univ of South Carolina, Charleston, SC.

    Purpose: The OPTN/UNOS added fields to the deceased donor registration form on 3/31/2015 to capture the intent to utilize ex vivo lung perfusion (EVLP) on…
  • 2018 American Transplant Congress

    Resuscitation and Viability Testing of Initially Declined Livers Using Sequential Hypo- and Normothermic Machine Perfusion with an Acellular Fluid

    Y. de Vries,1,2 A. Matton,1,2 S. Karangwa,1,2 M. Nijsten,3 R. de Kleine,2 A. van den Berg,4 V. de Meijer,2 P. Meyer,5 M. de Boer,2 R. Porte.2

    1Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; 2Section of HPB Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; 3Department of Critical Care, University Medical Center Groningen, Groningen, Netherlands; 4Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; 5Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.

    While end-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) resuscitates mitochondria and reduces ischemia-reperfusion injury, normothermic machine perfusion (NMP) allows for ex-situ functional testing of donor…
  • 2018 American Transplant Congress

    The Superiority of Plasma Enriched Perfusate for Assessment of Donor Kidneys in an Ex-Vivo Normothermic Perfusion (EVNP) Setting

    J. Palma, I. Palma, Y. Smolin, A. Perry, J. Sageshima, R. Perez.

    Surgery, Transplant Division, UC Davis Health System, Sacramento, CA.

    EVNP has been used to assess and repair marginal organs prior to transplantation but the optimal perfusate composition is unknown. We hypothesize that EVNP with…
  • 2018 American Transplant Congress

    Differences in Preservation Solution Formulas and Its Effects on Early Graft Function

    J. Brooks, P. Wiederhold, K. Jiles, A. Chiodo Ortiz, M. Dewey, M. Bailey, N. Koizumi, E. Rady, J. Ortiz.

    University of Toledo Medical Center, Toledo, OH; University of California-Los Angeles, Los Angeles, CA; Life Connection of Ohio, Maumee, OH; George Mason University, Fairfax, VA.

    Introduction: Machine perfusion has proven benefits and is common practice among transplant centers. However, the formulas of preservation solutions vary between organ procurement organizations (OPOs).…
  • 2017 American Transplant Congress

    Ex-Situ Extended Limb Preservation: A Protocol for Porcine Limb Perfusion.

    E. Dalla Pozza,1 E. Duraes,1 M. Madajka,1 R. Frautschi,1 K. Cho,1 N. Dawlagala,1 V. Fahradyan,1 H. Shah,1 C. Cakmakoglu,1 C. Quintini,2 F. Papay,1 A. Rampazzo,1 B. Bassiri Gharb.1

    1Plastic Surgery, Cleveland Clinic, Cleveland, OH; 2General Surgery, Cleveland Clinic, Cleveland, OH

    Background: Ischemia and reperfusion injury remains a significant limiting factor for the success of vascularized composite allotransplantation. Compared to the cold storage of the procured…
  • 2017 American Transplant Congress

    Twelve Hour Ex Vivo Normothermic Perfusion for the Assessment of High-Risk Discarded Deceased Donor Kidneys.

    I. Palma, I. Palma, Y. Smolin, S. Kabagambe, A. Perry, J. Sageshima, R. Perez.

    Department of Surgery, UC Davis Medical Center, Sacramento, CA

    Ex-Vivo Normothermic Perfusion (EVNP) has been shown to be useful to assess viability of high-risk deceased donor kidneys, with high renal blood flow and immediate…
  • 2017 American Transplant Congress

    The Use of a Furosemide Stress Test (FST) for Assessment of Discarded Deceased Donor Kidneys in an Ex-Vivo Normothermic Perfusion Model.

    I. Palma, Y. Smolin, S. Kabagambe, A. Perry, I. Palma, J. Sageshima, R. Perez.

    Department of Surgery, UC Davis Medical Center, Sacramento, CA

    Studies have shown that Ex-Vivo Normothermic Perfusion (EVNP) has the potential to assess viability and function of high-risk deceased donor kidneys. A diuretic response to…
  • 2017 American Transplant Congress

    The Use of an Haemoglobin Based Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion.

    Y. Boteon,1 R. Laing,1 R. Bogal,1 D. Neil,2 A. Smith,2 B. Stephenson,2 A. Schlegel,2 S. Hübscher,2 D. Mirza,2 S. Afford,1 H. Mergental.2

    1Center of Liver Research, University of Birmingham, Birmingham, United Kingdom; 2Liver Unit Queen Elizabeth Hospital, University Hospital Birmingham, Birmingham, United Kingdom

    Normothermic machine perfusion of the liver (NMP-L) is a novel technique that preserves liver grafts in an environment that mimics physiological conditions and therefore enables…
  • 2017 American Transplant Congress

    The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.

    G. Weber,1 N. Ambrosi,2 F. Caro,2 S. Beltramino,1 A. Fernández,1 I. Cabrera,1 G. Hilchenbach,1 D. Fernandez,1 C. Incardona,3 E. Chuluyan,2 D. Casadei.1

    1Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; 2CEFYBO, Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina; 3Fundación GADOR, Buenos Aires, Argentina

    A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…
  • 2016 American Transplant Congress

    Creation of a Small Animal Model of Ex-Vivo Normothermic Perfusion (EVNP) for Treatment of Kidney Ischemia-Reperfusion (I/R) Injury.

    Y. Smolin, I. Palma, C. Pivetti, S. Kabagambe, J. Woloszyn, Y. Chen, T. Boyer, I. Palma, J. Sageshima, C. Santhanakrishnan, R. Perez.

    Department of Surgery, UC Davis Medical Center, Sacramento, CA.

    Purpose: Recent studies have suggested that EVNP may be utilized to assess and repair marginal donor organs subjected to severe I/R injury. The lack of…
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