Articles tagged "Perfusion solutions"

2022 American Transplant Congress
Growing Use of Perfusion for Heart, Liver, and Lung and Early Outcomes
R. R. Goff¹, K. Gauntt¹, W. Cherikh¹, E. D. Lease², D. Klassen¹
¹United Network for Organ Sharing, Richmond, VA, ²University of Washington, Seattle, WA
*Purpose: In 2015 the OPTN began collecting data on perfusion for heart, liver, and lung deceased donors (DD) on the DD registration form. Since 2015,…
2022 American Transplant Congress
Normothermic Organ Preservation: The New Standard?
K. Mistry
Sanford Health, Fargo, ND
*Purpose: Normothermic perfusion (NMP) is a new technique that has been introduced into transplantation expanding capacity for organ utilization. NMP has been shown to be…
2022 American Transplant Congress
Tissue Edema Following Hypothermic Machine Perfusion of a Small Animal Hind Limb Graft
D. Yoeli, Y. Wang, B. Li, J. Huang, S. Jain, Z. Wang, N. Nakra, N. Limon De La Rosa, K. Rampalski, A. Su, D. Mathes, K. Washington, E. Farkash, A. Jani, C. Huang
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: The aim of this study was to evaluate the capability of preserving a small animal hind limb graft for 24 hours with hypothermic machine…
2021 American Transplant Congress
Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA
M. Goutard¹, R. J. de Vries¹, A. G. Lellouch¹, E. Lupon¹, C. Pendexter¹, S. N. Tessier¹, M. A. Randolph¹, L. Lantieri², C. L. Cetrulo¹, K. Uygun¹
¹Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, MA, ²Hôpital Européen Georges Pompidou, Paris, France
*Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…
2021 American Transplant Congress
Nanoparticle Mediated Drug Delivery for Lung Transplantation
P. M. Patel¹, S. Jung², C. L. Miller¹, J. M. O¹, T. Costa¹, A. Dehnadi¹, I. Hanekamp¹, X. F. Li², L. Jiang², H. Ichimura², A. Azimzadeh¹, J. C. Madsen³, R. Abdi²
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Medicine, Transplant Research Center, Brigham and Women's Hospital, Boston, MA, ³Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Severe primary graft dysfunction (PGD) affects 30% of lung transplant patients. Pulmonary alveolar macrophages play a significant role in lung PGD, but systemic immunotherapy…
2021 American Transplant Congress
Successful Long Term Survival of Vascularized Composite Allografts After Extended Preservation at Subzero Temperatures Using Bioinspired Next Generation Cryoprotectants
M. Kline¹, S. Fidder², A. Callegari¹, A. Matoso², B. Oh², K. Lombardo², J. Etra², D. Vasilic³, A. Childs¹, R. Redett², G. Brandacher², X. Wei¹
¹X-Therma Inc., Richmond, CA, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Erasmus MC, Rotterdam, Netherlands
*Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for patients with devastating tissue defects. However, the field is constrained by short tolerable ischemia…
2021 American Transplant Congress
Composition of Ex Vivo Lung Perfusion Solutions and Kinetics Define Differential Cytokine and Chemokine Secretion in a Porcine Cardiac Arrest Model of Lung Preservation
L. M. Radomsky¹, A. Koch², C. Olbertz², J. F. Kuehne¹, Y. Liu², J. Keil¹, K. Beushausen¹, U. Rauen³, C. S. Falk¹, M. Kamler²
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Thoracic Transplantation, Department of Thoracic and Cardiovascular Surgery, University Hospital Essen, Essen, Germany, ³Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany
*Purpose: Ex vivo lung perfusion is an innovative technique to evaluate marginal lung organs especially after DCD. Normothermic continuous perfusion should reduce ischemic damage and…
2021 American Transplant Congress
Determining Endpoint Criteria in Ex Vivo Normothermic Limb Perfusion (EVNLP)
S. K. Pandey¹, A. Meyers¹, P. Sadeghi¹, V. Kopparthy¹, T. Xia¹, H. Brunengraber², S. Dasarathy³, A. Rampazzo¹, B. Bassiri Gharb¹
¹Plastic Surgery, Cleveland Clinic, Cleveland, OH, ²Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH, ³Department of Gastroenterology, Cleveland Clinic, Cleveland, OH
*Purpose: There are no established criteria for discontinuing EVNLP before irreversible muscle and endothelial cell damage occur. This study aimed to evaluate weight gain as…
2020 American Transplant Congress
Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage: Preliminary Clinical Experience from a Prospective, Multi-Center Randomized Controlled Trial
G. G. Panayotova¹, R. Quillin III², F. Paterno¹, K. Lunsford¹, M. A. McCarty¹, A. Bailey², G. Dikdan¹, J. Rosado¹, S. Shah², J. V. Guarrera¹
¹Transplant and HPB Surgery, Rutgers NJMS, Newark, NJ, ²Division of Transplantation, University of Cincinnati, Cincinnati, OH
*Purpose: Hypothermic oxygenated machine perfusion (HMP-O2) is a novel liver preservation technique currently in clinical trials. It has the potential to mitigate ischemia/reperfusion injury, as…
2020 American Transplant Congress
Using an Ex Vivo Blood-Free Model of Preservation and Reperfusion to Evaluate the Effects of Subnormothermic Perfusion with Hydrogen Sulfide on DCD Porcine Renal Grafts
S. Juriasingani¹, A. Ruthirakanthan¹, M. Richard-Mohamed², M. Zhang¹, M. Levine¹, E. Sogutdelen¹, M. Mandurah¹, A. Sener¹
¹University of Western Ontario, London, ON, Canada, ²London Health Sciences Centre, London, ON, Canada
*Purpose: The need for donor blood complicates the clinical translation of normothermic and subnormothermic perfusion for preservation and graft function evaluation. As such, hemoglobin-based oxygen…