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Articles tagged "Perfusion solutions"

  • 2022 American Transplant Congress

    Normothermic Organ Preservation: The New Standard?

    K. Mistry

    Sanford Health, Fargo, ND

    *Purpose: Normothermic perfusion (NMP) is a new technique that has been introduced into transplantation expanding capacity for organ utilization. NMP has been shown to be…
  • 2022 American Transplant Congress

    Tissue Edema Following Hypothermic Machine Perfusion of a Small Animal Hind Limb Graft

    D. Yoeli, Y. Wang, B. Li, J. Huang, S. Jain, Z. Wang, N. Nakra, N. Limon De La Rosa, K. Rampalski, A. Su, D. Mathes, K. Washington, E. Farkash, A. Jani, C. Huang

    University of Colorado Anschutz Medical, Aurora, CO

    *Purpose: The aim of this study was to evaluate the capability of preserving a small animal hind limb graft for 24 hours with hypothermic machine…
  • 2022 American Transplant Congress

    Growing Use of Perfusion for Heart, Liver, and Lung and Early Outcomes

    R. R. Goff1, K. Gauntt1, W. Cherikh1, E. D. Lease2, D. Klassen1

    1United Network for Organ Sharing, Richmond, VA, 2University of Washington, Seattle, WA

    *Purpose: In 2015 the OPTN began collecting data on perfusion for heart, liver, and lung deceased donors (DD) on the DD registration form. Since 2015,…
  • 2021 American Transplant Congress

    Composition of Ex Vivo Lung Perfusion Solutions and Kinetics Define Differential Cytokine and Chemokine Secretion in a Porcine Cardiac Arrest Model of Lung Preservation

    L. M. Radomsky1, A. Koch2, C. Olbertz2, J. F. Kuehne1, Y. Liu2, J. Keil1, K. Beushausen1, U. Rauen3, C. S. Falk1, M. Kamler2

    1Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Thoracic Transplantation, Department of Thoracic and Cardiovascular Surgery, University Hospital Essen, Essen, Germany, 3Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany

    *Purpose: Ex vivo lung perfusion is an innovative technique to evaluate marginal lung organs especially after DCD. Normothermic continuous perfusion should reduce ischemic damage and…
  • 2021 American Transplant Congress

    Determining Endpoint Criteria in Ex Vivo Normothermic Limb Perfusion (EVNLP)

    S. K. Pandey1, A. Meyers1, P. Sadeghi1, V. Kopparthy1, T. Xia1, H. Brunengraber2, S. Dasarathy3, A. Rampazzo1, B. Bassiri Gharb1

    1Plastic Surgery, Cleveland Clinic, Cleveland, OH, 2Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH, 3Department of Gastroenterology, Cleveland Clinic, Cleveland, OH

    *Purpose: There are no established criteria for discontinuing EVNLP before irreversible muscle and endothelial cell damage occur. This study aimed to evaluate weight gain as…
  • 2021 American Transplant Congress

    Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA

    M. Goutard1, R. J. de Vries1, A. G. Lellouch1, E. Lupon1, C. Pendexter1, S. N. Tessier1, M. A. Randolph1, L. Lantieri2, C. L. Cetrulo1, K. Uygun1

    1Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, MA, 2Hôpital Européen Georges Pompidou, Paris, France

    *Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…
  • 2021 American Transplant Congress

    Nanoparticle Mediated Drug Delivery for Lung Transplantation

    P. M. Patel1, S. Jung2, C. L. Miller1, J. M. O1, T. Costa1, A. Dehnadi1, I. Hanekamp1, X. F. Li2, L. Jiang2, H. Ichimura2, A. Azimzadeh1, J. C. Madsen3, R. Abdi2

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Medicine, Transplant Research Center, Brigham and Women's Hospital, Boston, MA, 3Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    *Purpose: Severe primary graft dysfunction (PGD) affects 30% of lung transplant patients. Pulmonary alveolar macrophages play a significant role in lung PGD, but systemic immunotherapy…
  • 2021 American Transplant Congress

    Successful Long Term Survival of Vascularized Composite Allografts After Extended Preservation at Subzero Temperatures Using Bioinspired Next Generation Cryoprotectants

    M. Kline1, S. Fidder2, A. Callegari1, A. Matoso2, B. Oh2, K. Lombardo2, J. Etra2, D. Vasilic3, A. Childs1, R. Redett2, G. Brandacher2, X. Wei1

    1X-Therma Inc., Richmond, CA, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Erasmus MC, Rotterdam, Netherlands

    *Purpose: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for patients with devastating tissue defects. However, the field is constrained by short tolerable ischemia…
  • 2020 American Transplant Congress

    Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage: Preliminary Clinical Experience from a Prospective, Multi-Center Randomized Controlled Trial

    G. G. Panayotova1, R. Quillin III2, F. Paterno1, K. Lunsford1, M. A. McCarty1, A. Bailey2, G. Dikdan1, J. Rosado1, S. Shah2, J. V. Guarrera1

    1Transplant and HPB Surgery, Rutgers NJMS, Newark, NJ, 2Division of Transplantation, University of Cincinnati, Cincinnati, OH

    *Purpose: Hypothermic oxygenated machine perfusion (HMP-O2) is a novel liver preservation technique currently in clinical trials. It has the potential to mitigate ischemia/reperfusion injury, as…
  • 2020 American Transplant Congress

    Using an Ex Vivo Blood-Free Model of Preservation and Reperfusion to Evaluate the Effects of Subnormothermic Perfusion with Hydrogen Sulfide on DCD Porcine Renal Grafts

    S. Juriasingani1, A. Ruthirakanthan1, M. Richard-Mohamed2, M. Zhang1, M. Levine1, E. Sogutdelen1, M. Mandurah1, A. Sener1

    1University of Western Ontario, London, ON, Canada, 2London Health Sciences Centre, London, ON, Canada

    *Purpose: The need for donor blood complicates the clinical translation of normothermic and subnormothermic perfusion for preservation and graft function evaluation. As such, hemoglobin-based oxygen…
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