ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Perfusion"

  • 2022 American Transplant Congress

    CD31+ Extracellular Vesicles in Ex Vivo Lung Perfusion Are Associated with Unsuitability for Transplant

    G. C. Madu1, S. Moshkelgosha2, A. Chruscinski3, A. Sage2, M. Cypel2, S. Keshavjee2, S. Juvet2

    1Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada, 2University Health Network, Toronto, ON, Canada, 3Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada

    *Purpose: Primary graft dysfunction (PGD) is an important cause of morbidity and mortality following lung transplantation and results in part from injuries sustained in the…
  • 2022 American Transplant Congress

    Organ Care System Use in Liver Transplantation Shifts Preservation-Reperfusion Injury in Time and Space

    A. J. Demetris, M. A. Wood-Trageser, D. Lesniak, -. The PROTECT Investigators

    Department of Transplant Pathology, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Liver allograft ischemia-reperfusion injury (IRI) causes early allograft dysfunction (EAD). The TransMedics Organ Care System (OCS) PROTECT trial for liver transplantation (NCT02522871) revealed that…
  • 2022 American Transplant Congress

    Proteomic Profiling of Bile from Human Livers Undergoing Viability Assessment via Normothermic Machine Perfusion Prior to Transplantation

    A. M. Thorne1, J. C. Wolters2, F. Kuipers1, R. J. Porte1, V. E. de Meijer1

    1University Medical Center Groningen, Groningen, Netherlands, 2University of Groningen, Groningen, Netherlands

    *Purpose: Normothermic machine perfusion (NMP) has gained increasing traction as a method to assess the viability of high-risk donor livers. To avoid post-transplant biliary complications,…
  • 2022 American Transplant Congress

    The Association Between Renal Anatomy Data and Kidney Utilization

    A. M. Placona, C. Martinez, K. McCharen, B. Shean, M. Stuart

    United Network for Organ Sharing, Richmond, VA

    *Purpose: Renal anatomy data, such as hard arterial plaque or discoloration, can be available as PDF attachments uploaded to DonorNet during the organ evaluation process.…
  • 2022 American Transplant Congress

    Deceased Donor Organ Flush with Similar Volumes of HTK and UW at a Single U.S. Organ Procurement Organization: Adult and Pediatric Data

    A. E. Mangus1, C. Kubal2, B. Ekser3, P. Mihaylov4, A. J. Lutz1, J. Fridell5, R. Mangus6

    1Indiana University Purdue University of Indianapolis, Indianapolis, IN, 2Indiana University Hospital, Indianapolis, IN, 3Surgery, Indiana University - Transplant Surgery, Indianapolis, IN, 4Indiana Univ School of Medicine, Indianapolis, IN, 5Indiana University School of Medicine, Indianapolis, IN, 6Indiana University, Indianapolis, IN

    *Purpose: Histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) solutions are the two primary solid-organ preservation solutions used in the United States (>95%), but flush volumes…
  • 2022 American Transplant Congress

    Hypothermic Pulsatile Flush of Hepatitis C Virus (HCV) RNA Positive Kidney Reduces Viral Load

    A. Jain1, W. Greene2

    1Transplant Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, 2Dept. of Pathology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA

    *Purpose: Does Hypothermic pulsatile flush of hepatitis C virus (HCV) RNA positive kidney reduce the viral load?*Methods: Unutilized, HCV RNA-positive deceased donor kidneys were obtained…
  • 2022 American Transplant Congress

    Normothermic Organ Preservation: The New Standard?

    K. Mistry

    Sanford Health, Fargo, ND

    *Purpose: Normothermic perfusion (NMP) is a new technique that has been introduced into transplantation expanding capacity for organ utilization. NMP has been shown to be…
  • 2022 American Transplant Congress

    Significant Reduction of Troponin I Elaboration After Ischemia Minimization in the First Hour of Ex Vivo Xeno Heart Perfusion

    F. Pollok1, M. R. Connolly1, A. Calhoun1, Z. Habibabady1, S. Miura1, M. Ma1, S. Pratts1, L. Burdorf1, Y. Kan2, J. V. Layer2, J. V. Layer2, E. Tan2, R. Anand2, M. Li2, K. C. Hall2, M. E. Youd2, K. Stiede2, W. Qin2, M. Curtis2, A. Azimzadeh1, R. N. Pierson1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Cambridge, MA, 2eGenesis Inc., Cambridge, MA

    *Purpose: Previous studies showed that ischemia minimization (IM), accomplished by perfusing the heart xenograft during storage, prevents ‘initial cardiac xenograft dysfunction’ (ICXD) and enables prolonged…
  • 2022 American Transplant Congress

    Normal Saline vs Electrolyte-a Use Peri- and Post-Operatively in Adult Kidney Transplant Recipients

    K. R. Szempruch, A. D. Martschenko, H. Arora, R. Isaak, R. Prasad, P. Serrano

    UNC Medical Center, Chapel Hill, NC

    *Purpose: 0.9% normal saline (NS) has been used as the standard fluid replacement in kidney transplant recipients (KTRs) to prevent dehydration and to improve renal…
  • 2022 American Transplant Congress

    Liver and Kidney Transplantation from Donation After Circulatory Death Heart Donors in the US: Better Early Outcomes with Normothermic Regional Perfusion versus Cold Flush

    M. Rosenzweig1, R. Ruiz2, E. Martinez1, A. Gupta1, H. Fernandez1, S. Lee1, N. Onaca1, J. Bayer1, G. J. McKenna1, T. Ma1, G. Testa3, A. Wall1

    1Baylor University Medical Center, Dallas, TX, 2Baylor University Medical Center, Fort Worth, TX, 3Baylor Dallas, Dallas, TX

    *Purpose: Donation after circulatory death (DCD) heart donation is increasingly common in the US. The two methods for DCD heart donation are normothermic regional perfusion…
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