Articles tagged "Peptides"

2022 American Transplant Congress
Pegylated Lacritin N-104 Promotes Mouse Islet Stabilization and Prevents Diabetes Progression in the Non-Obese Diabetic (NOD) Mouse Model
M. Ma¹, P. Chhabra¹, G. Laurie², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Cell Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if PEGylated Lacritin N-104 (PEG N-104) prevents the progression of type 1 diabetes (T1D) in the NOD mouse.*Background: Lacritin is a multifunctional…
2022 American Transplant Congress
Angiotensin II-Regulated Proteins Production by Pulmonary Macrophages in Chronic Lung Allograft Dysfunction
S. Farkona¹, A. Duong², G. Berra², S. Moshkelgosha², S. Clotet-Freixas¹, S. Juvet², T. Martinu², A. Konvalinka¹
¹Toronto General Hospital Research Institute and Multi-Organ Transplant, University Health Network, Toronto, ON, Canada, ²Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD), characterized by fibrosis, is the most important cause of mortality after lung transplantation. CLAD mechanisms remain poorly understood and…
2021 American Transplant Congress
Lacripep^TM-like Peptide N-104 Promotes Beta Cell Proliferation in Murine Pancreatic Islets
M. Ma, P. Chhabra, K. Fread, K. Dias Teixeira, G. Laurie, K. Brayman
University of Virginia Health System, Charlottesville, VA
*Purpose: To monitor time-dependent cellular changes, with emphasis on beta cell regeneration, in pancreatic islets following treatment with LacripepTM-like peptide N-104 by mass cytometry. Background:…
2021 American Transplant Congress
CHBP Induces Stronger Immunosuppressive CD127⁺ M-MDSC via Erythropoietin Receptor
C. Yang
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: Erythropoietin (EPO) is not only an erythropoiesis hormone, but also an immune regulatory cytokine. The receptors of EPO, (EPOR)2 and tissue protective receptor (TPR),…
2021 American Transplant Congress
Lacripep^TM-like Peptide N-104 Increases Insulin Secretion and Promotes Islet Transplantation Outcomes
M. Ma, P. Chhabra, K. Dias Teixeira, G. Laurie, K. Brayman
University of Virginia Health System, Charlottesville, VA
*Purpose: To study if LacripepTM-like peptide N-104 promotes beta-cell stabilization and islet transplantation outcomes. Background: Lacritin is a multifunctional tear protein with prosecretory, prosurvival and…
2020 American Transplant Congress
microPOTS: A New Single Cell Proteomic Method for Profiling Human Kidney Transplant Biopsy Tissue
T. Sigdel¹, P. Piehowski², S. Roy¹, J. Liberto¹, A. Schroeder¹, P. Rashmi¹, S. Sur¹, I. Damm¹, W. Qian², M. M. Sarwal¹
¹University of California San Francisco, San Francisco, CA, ²Pacific Northwest National Laboratory, Richland, WA
*Purpose: The purpose of this study was to interrogate acute rejection (AR) in the renal allograft at single cell level. Despite advances in single cell…
2020 American Transplant Congress
Association of Kidney Allograft Fibrosis-Associated Proteins with Chronic Lung Allograft Dysfunction
S. Farkona¹, G. Berra², Z. Mohammed-Ali¹, P. Ly², L. Levy², B. Renaud-Picard², G. Zehong², T. Daigneault², S. Juvet², C. McEvoy¹, S. Clotet-Freixas¹, T. Martinu², A. Konvalinka¹
¹Nephrology, Toronto General Hospital Research Institute and Multi-Organ Transplant, University Health Network, Toronto, ON, Canada, ²Lung Transplantation, Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) remains the leading cause of long-term mortality after lung transplant. Non invasive biomarkers that could assist in early diagnosis…
2020 American Transplant Congress
Does Pretransplant C-Peptide Influence Outcomes Following Simultaneous Pancreas-Kidney Transplantation: A Case-Control Study
V. Gurram, K. Gurung, J. Rogers, A. Farney, G. Orlando, C. Jay, A. Reeves-Daniel, A. Mena-Gutierrez, N. Sakhovskaya, W. Doares, S. Kaczmorski, M. Gautreaux, R. Stratta
Abdominal Transplant Surgery, Wake Forest Baptist Health, Winston Salem, NC
*Purpose: The study purpose was to evaluate outcomes in SPKT pts according to presence or absence of pretransplant Cp*Methods: Selection criteria for Cp positive (Cp+,…
2020 American Transplant Congress
Characterization of Non HLA Antibodies in Kidney Transplant Recipients
S. Rodriguez Ramirez¹, S. Clotet-Freixas¹, C. Mcevoy¹, M. Kotlyar², I. Jurisica², A. Chruscinski¹, A. Konvalinka³
¹Kidney Transplant, Toronto General Hospital Research Institute, Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Kidney Transplant, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Kidney Transplant, Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody mediated rejection (AMR) causes more than 60 percent of late graft failures in kidney transplants (KT). Although antiHLA donor specific antibodies are the…
2019 American Transplant Congress
Quantitative Proteomics Analysis of Ischemia Reperfusion Injured Liver Tissue Provides Insight into Liver Allograft Quality Evaluation
M. Chen, M. Han, W. Ju, Q. Zhao, D. Wang, Z. Guo, X. He
Transplant Center, Sun Yat-sen University, Guangzhou, China
*Purpose: Successful orthotopic liver transplantation (OLT) surgery mostly depends on good and functional liver donor, besides of mature transplant technology. The molecular basis of different…