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Articles tagged "Pediatric"

  • 2015 American Transplant Congress

    Clinical Utility of Allospecific CD154+T-Cells in Children With Liver Or Intestine Transplantation (LTx, ITx)

    K. Soltys, G. Bond, G. Mazariegos, C. Ashokkumar, K. Dirling, L. O'Toole, P. Kachmar, T. Hartle, D. Martin, C. Trautz, R. Sindhi.

    Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    Background: Allospecific CD154+T-cytotoxic memory (CD154+TcM) have completed investigational evaluation as predictors of acute cellular rejection in children with LTx or ITx.Purpose: To evaluate CD154+TcM** as…
  • 2015 American Transplant Congress

    Mechanisms Underlying Treg Dysfunction in DAIH- Role for PD-L1?

    A. Arterbery,1 M. Martinez,2 S. Lobritto,2 Y. Avitzur,3 K. Raddassi,1 M. Kleinewietfeld,4 U. Ekong.1

    1Yale, NH; 2Columbia, NY; 3HSC, Toronto, Canada; 4Dresden University of Technology, Dresden, Germany.

    Background: we have previously shown that ex vivo Tregs from patients with DAIH demonstrate differentiation plasticity towards TH17. To understand the mechanisms underlying this we…
  • 2015 American Transplant Congress

    Pubertal Development in Pediatric Kidney Transplant Patients Receiving Everolimus Or Conventional Immunosuppression

    L. Pape,1 T. Ahlenstiel-Grunow,1 A. Zapf,2 M. Mynarek,3 J. Förster.1

    1Pediatric Nephrology, Hannover Medical School, Hannover, NDS, Germany; 2Medical Statistics, University Medical Center Göttingen, Göttingen, NDS, Germany; 3Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

    TOR inhibitors (mTORi) have been discussed to eventually influence pubertal development after pediatric kidney transplantation (Tx).This is the first trial to compare pubertal development in…
  • 2015 American Transplant Congress

    Effective Long-Term Prophylaxis against De Novo Hepatitis B With Hepatitis B Vaccination in Pediatric Recipients of HbcAb-Positive Liver Grafts

    S. Lee, J.-M. Kim, G.-S. Choi, C.-H. Kwon, J.-W. Joh, S.-K. Lee.

    Department of Surgery, Samsung Medical Center, Seoul, Korea.

    Background) Controversy still exists concerning the use of livers from hepatitis B surface antigen-negative (HBsAg-)/hepatitis B core antibody-positive (HBcAb+) donors for liver transplantation (LT). We…
  • 2015 American Transplant Congress

    Assessment of Actual Pediatric Organ Donation Potential: Neurologic and Circulatory Determination of Death at a Children's Hospital

    C. Aguayo,1 E. Bennett,2 J. Sweney,2 C. Myrick,1 S. Bratton.2

    1Intermountain Donor Services, Salt Lake City, UT; 2Pediatrics, University of Utah, Salt Lake City, UT.

    BACKGROUND AND OBJECTIVES: Organ donation after circulatory determination of death (DCDD) is increasing. DCDD offers potential for additional abdominal organ donation. We evaluated all dying…
  • 2015 American Transplant Congress

    An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation

    C. Falk,1 I. Goldschmidt,2 F. Mutschler,2 C. Neudörfl,1 J. Keil,1 K. Daemen,1 F. Lehner,3 R. Mikolajzcyk,4 A. Karch,4 U. Baumann.2

    1Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; 2Division of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany; 3Department of Visceral General and Transplant Surgery, Hannover Medical School, Hannover, Germany; 4Department of Epidemiology, Helmholtz Center for Infection Research, HZI, Braunschweig, Braunschweig, Germany.

    The concept of a coordinated immune response initiated by innate and sustained by adaptive immune cells and their soluble mediators is well established for infection…
  • 2015 American Transplant Congress

    High Incidence of Masked Hypertension in Pediatric Recipients of Stem Cell Transplantation

    A. Melk,1 D. Thurn-Valsassina,1 B. Schmidt,2 R. Beier.3

    1Pediatric Nephrology, Hannover Medical School, Hannover, Germany; 2Nephrology, Hannover Medical School, Hannover, Germany; 3Pediatric Hematology, Hannover Medical School, Hannover, Germany.

    Purpose: Different from recipients of a solid organ transplant, stem cell transplantation (SCT) recipients do not receive long term immunosuppressive treatment that may cause renal…
  • 2015 American Transplant Congress

    Standardizing Quality Improvement Practices in Pediatric Liver Transplantation: The SPLIT A3 Project

    B. Kelly,1 R. Himes,2 J. Bucuvalas,3 L. Ware,1 S. Horslen.4

    1Surgery, Children's Hospital Pittsburgh, Pittsburgh, PA; 2Pediatrics, Texas Children's Hospital, Houston, TX; 3Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH; 4Pediatrics, Seattle Children's Hospital, Seattle, WA; 5The Studies of Pediatric Liver Transplantation, EMMES Corporation, Maryland.

    Quality improvement (QI) programs are key drivers of continual reform in process and patient safety, but at present, there are no pediatric liver transplant (PLT)-specific…
  • 2015 American Transplant Congress

    The Use of Inhaled Tobramycin in Pediatric Transplant Patients Without Cystic Fibrosis

    C. Pfeifer,1 M. Keck.2

    1Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY; 2Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE.

    Purpose:To evaluate dosing strategies used and systemic levels achieved of inhaled tobramycin in pediatric patients without cystic fibrosis (CF)Methods:A retrospective single-center chart review was performed…
  • 2015 American Transplant Congress

    Does Higher Cost Improve Outcome in Pediatric Liver Transplantation?

    J. Minneman, J. Grijalva, S. Rangel, H. Kim, K. Vakili.

    Surgery, Boston Children's Hospital, Boston, MA.

    Examine the relationship between transplant-related total cost and 1-year graft failure and patient mortality rate for liver transplantation at freestanding children's hospitals.Using the Pediatric Health…
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