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Articles tagged "Pediatric"

  • 2018 American Transplant Congress

    Building a Third-Party VST Bank from Scratch- The Cincinnati Experience

    A. S. Nelson,1 D. Heyenbruch,2 X. Zhu,3 S. M. Davies,1 C. Lutzko,3 C. Bollard,4 P. Hanley,4 T. Leemhuis,2 L. Danziger-Isakov,5 M. S. Grimley.1

    1Bone Marrow Transplant & Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 2Hoxworth Blood Center, Univeristy of Cincinnati, Cincinnati, OH; 3Experimental Hematology & Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 4Proram for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System, Washington, DC; 5Depatment of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

    BackgroundViral infections remain a challenge to treat and significantly contribute to morbidity and mortality. Virus specific T cells (VSTs) have shown clinical efficacy, with minimal…
  • 2018 American Transplant Congress

    Worsening Racial/Ethnic Disparities in Pediatric Kidney Transplant Outcomes in the US

    T. Purnell, X. Luo, L. Cooper, D. Crews, K. Covarrubias, A. Massie, D. Segev.

    Johns Hopkins, Baltimore.

    Purpose: We recently demonstrated narrowed racial/ethnic disparities in adult kidney transplant (KT) outcomes in the US. The goal of this study was to examine twenty-year…
  • 2018 American Transplant Congress

    Medication Adherence: Does Where You Live Matter?

    S. Wadhwani,1 S. Taylor,1 C. Brokamp,1 W. Guo,1 E. Shemesh,2 J. Bucuvalas.1

    1Cincinnati Children's Hospital Medical Center, Cincinnati; 2Mount Sinai School of Medicine, New York.

    Background & Objectives: Medication non-adherence remains problematic in pediatric liver transplant (LT)[mdash]estimates suggest that up to 53% of adolescents are non-adherent. We leveraged data from…
  • 2018 American Transplant Congress

    Long-Term Follow-Up of Pediatric Kidney Recipients Who Received Alemtuzumab Induction

    D. Harriman, A. Chen, J. Rogers, R. Stratta, G. Orlando, A. South, J-.J. Lin, A. Farney.

    Surgery, Pediatrics, Cardiovascular Sciences Center, Wake Forest Baptist Medical Center, Winston-Salem, NC.

    Introduction: Experience with alemtuzumab (alem) depleting antibody induction has rarely been studied in the pediatric population, and reports that exist have limited follow-up. The purpose…
  • 2018 American Transplant Congress

    Utilization of Public Health Service Increased Risk Kidneys in Pediatric Renal Transplant Recipients by Era

    M. Meyers,1 J. Shults,1 B. Laskin,1 P. Porrett,2 M. Levine,2 P. Abt,2 S. Amaral,1,2 D. Goldberg.2

    1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.

    Purpose: Donors labeled Public Health Service Increased Risk (PHS-IR) continue to rise due to opioid abuse and expanding criteria defining 'increased-risk.' Many PHS-IR donors are…
  • 2018 American Transplant Congress

    Outcomes of Renal Transplantation in Pediatric Patients with VACTERL Association

    J. Diaz,1 B. Chavers,2 S. Chinnakotla,3 P. Verghese.2

    1Medical School, University of Minnesota, Minneapolis, MN; 2Pediatric Nephrology, University of Minnesota, Minneapolis, MN; 3Transplant Surgery, University of Minnesota, Minneapolis, MN.

    In this single-center retrospective review, we studied transplant outcomes in nine pediatric patients with VACTERL association, making this the largest study of its kind. Of…
  • 2018 American Transplant Congress

    Efficacy and Safety of Immediate- and Prolonged-Release Tacrolimus in De Novo Pediatric Transplantation: Randomized Study

    K. Vondrak,1 F. Parisi,2 A. Dhawan,3 R. Grenda,4 N. Webb,5 S. Marks,6 D. Debray,7 R. Holt,8 A. Lachaux,9 D. Kelly,10 G. Kazeem,11 N. Undre.11

    1University Hospital Motol, Prague, Czech Republic; 2Osp Pediatrico Bambino Ges[ugrave], Rome, Italy; 3King's College Hospital, London, United Kingdom; 4The Children's Memorial Health Institute, Warsaw, Poland; 5Manchester University Foundation Trust, Manchester, United Kingdom; 6Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; 7APHP-Hôpital Universitaire Necker, Paris, France; 8Alder Hey Children's Hospital, Liverpool, United Kingdom; 9Université Lyon 1 et Hospices Civils de Lyon, Lyon, France; 10Birmingham Children's Hospital, Birmingham, United Kingdom; 11Astellas Pharma Europe Ltd, Chertsey, United Kingdom.

    This study assessed long-term efficacy/safety of prolonged-release tacrolimus (PR-T) vs immediate-release tacrolimus (IR-T) in de novo pediatric transplant pts. Phase II, parallel-group, multicenter, open-label study…
  • 2018 American Transplant Congress

    Barriers and Disparities in Listing for Pediatric Solid Organ Transplant

    E. A. Steinberg,1 C. Buchanan,1 M. Wachs,1 S. Schmiege.2

    1Univ. of Colorado School of Medicine/Children's Hospital Colorado, Aurora, CO; 2Colorado School of Public Health, Aurora.

    Purpose The WHO recommends equitable access to transplant, yet disparities in listing based on gender, race, and education exist in adults. There is little research…
  • 2018 American Transplant Congress

    Assessment and Outcomes of Medication Nonadherence in Pediatric Kidney Transplant Recipients: Results from the IMPACT Study

    A. Dokras,1 M. Pearl,1 J. Peipert,1 P. Grimm,4 B. Warshaw,2 E. Chambers,3 A. Kirk,3 R. Ettenger.1

    1University of California, Los Angeles, Los Angeles, CA; 2Children's Healthcare of Atlanta and Emory University, Atlanta, GA; 3Duke University, Durham, NC; 4Stanford University, Palo Alto, CA.

    OBJECTIVE: Medication nonadherence (MNA) plays a key role in transplant (Tx) survival in pediatric kidney patients (pts). However, identification of MNA is challenging and tools…
  • 2018 American Transplant Congress

    Information Needs of Adolescent Transplant Recipients Transitioning to Adult Care

    B. Kosmach-Park,1 D. Shellmer,2 C. Nguyen,3 G. Mazariegos.2

    1Department of Transplant Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; 2Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; 3Department of Pediatric Nephrology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    Background: As adolescent and young adult (AYA) tx recipients transition to adulthood, a parallel transition in care is essential. The AYA should achieve skills for…
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