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Articles tagged "Pediatric"

  • 2018 American Transplant Congress

    Long-Term Efficacy and Safety of Prolonged-Release Tacrolimus in Stable Pediatric Allograft Recipients Converted from Immediate-Release Tacrolimus

    N. Undre,1 J. Rubik,2 D. Debray,3 D. Kelly,4 F. Iserin,5 N. Webb,6 P. Czubkowski,2 K. Vondrak,7 A-.L. Sellier-Leclerc,8 S. Riva,9 B. Tönshoff,10 L. D'Antiga,11 S. Marks,12 R. Reding,13 G. Kazeem.1

    1Astellas Pharma Europe Ltd, Chertsey, United Kingdom; 2Children's Memorial Health Institute, Warsaw, Poland; 3APHP-Hôpital Universitaire Necker, Paris, France; 4Birmingham Children's Hospital, Birmingham, United Kingdom; 5University Hospital Necker Enfants Malades, Paris, France; 6Manchester University Foundation Trust, Manchester, United Kingdom; 7University Hospital Motol, Prague, Czech Republic; 8Hôpital Femme-Mère-Enfant, Bron Cedex, France; 9ISMETT-IRCCSS, Palermo, Italy; 10University Children's Hospital, Heidelberg, Germany; 11Hospital Papa Giovanni XXIII, Bergamo, Italy; 12Great Ormond Street Hospital for Children, London, United Kingdom; 13Cliniques Universitaires Saint-Luc UCL, Brussels, Belgium.

    Study assessed long-term efficacy/safety of prolonged-release tacrolimus (PR-T) in stable solid organ allograft recipients (aged 5–16 yrs) who participated in a multicenter, Phase II pharmacokinetics…
  • 2018 American Transplant Congress

    Long-Term Outcome of Pediatric Kidney Transplantation: A Single-Center Experience over the past Three Decades in Japan

    Y. Aoki,1 H. Satoh,1 Z. Matsui,1 R. Hamada,2 Y. Hamasaki,3 S. Shishido.3

    1Urology and Kidney Transplantation, Tokyo Metropolitan Children's Medical Center, Fuchu-shi, Tokyo, Japan; 2Nephrology, Tokyo Metropolitan Children's Medical Center, Fuchu-shi, Tokyo, Japan; 3Nephrology, Toho University Faculty of Medicine, Ota-ku, Tokyo, Japan.

    Purpose: Kidney transplantation (KTx) is the preferred treatment for children with ESRD. Although the steady advances in immunosuppression have enabled control of early acute rejection…
  • 2018 American Transplant Congress

    Comparison of No Kasai Portoenterstomy to Failed Kasai: Analysis of UNOS Database

    T. Miloh, K. Hosek, S. Harpavath.

    Texas Children's Hospital/Baylor College of Medicine, Houston.

    IntroductionInfants with biliary atresia (BA) identified “later” (typically after 90 days of life) present a management challenge, as late Kasai portoenterostomy (KP) has high failure…
  • 2018 American Transplant Congress

    Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immunoregulatory Molecules Are Present in Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation

    M. Sharma,1 L. Danziger-Isakov,2 P. Heeger,3 S. Sweet,4 T. Mohanakumar.1

    1Norton Thoracic Insitute, St. Joseph's Hosp & Med Ctr, Phoenix; 2Cincinnati Children's Hosp Med Ctr, Cincinnati; 3Icahn Sch Med at Mt Sinai, New York; 4Washington Univ Sch Med, St. Louis.

    Exosomes containing mismatched donor HLA and lung restricted self-antigens (SAgs), Kα1 Tubulin (Kα1T) and Collagen V (Col-V), have demonstrated in sera and bronchoalveolar lavage fluid…
  • 2018 American Transplant Congress

    Increasing Use of Exceptions after Changes to Pediatric Heart Allocation

    A. Robinson,1 W. Mahle,2 R. Davies.3

    1United Network for Organ Sharing, Richmond, VA; 2Children's Healthcare of Atlanta, Atlanta, GA; 3Children's Medical Center of Dallas, Dallas, TX.

    Purpose: Pediatric heart allocation in the United States was changed in 2016. The primary goal was to better align candidate status with waitlist mortality. Whether…
  • 2018 American Transplant Congress

    The Impact of Childhood Solid Organ Transplantation on B-Cell Maturation

    L. Ionescu,1 T. Blydt-Hansen,2 B. Foster,7 S. Mital,3 L. Hamiwka,5 U. Allan,3 V. Phan,4 P. Birk,6 C. Morgan,1 S. Urschel.1

    1U of Alberta, Edmonton, Canada; 2U of BC, Vancouver, Canada; 3Hospital for Sick Children, Toronto, Canada; 4U de Montreal, Montreal, Canada; 5U of Calgary, Calgary, Canada; 6U of Manitoba, Winnipeg, Canada; 7McGill University, Montreal, Canada.

    Background:The developing immune system of childhood promotes better graft acceptance and longevity but also higher risk for infections and post-transplant (Tx) lymphoproliferative disorders. This may…
  • 2018 American Transplant Congress

    Patient and Graft Survival in Pediatric Renal Transplant Recipients Compared to Adult Multi-Organ (Kidney-Pancreas, Simultaneous Liver-Kidney, or Heart-Kidney) Transplant Recipients: An Analysis of OPTN Data

    P. Almond,1 S. Al-Akash,1 D. Stewart,2 A. Robinson.2

    1CPSST Departments of Surgery and Renal Transplantation, Driscoll Children's Hospital, Corpus Christi, TX; 2UNOS, Richmond, VA.

    Under the current kidney allocation system (KAS), pediatric (PED) renal transplant (RTx) candidates have a priority to kidneys from donors with KDPI <35%. However, multi-organ…
  • 2018 American Transplant Congress

    Prevalence of Abnormal Hemoglobin A1C in Pediatric Kidney Transplant Recipients

    A. Serluco,1 R. Liverman,1 R. George,1,2 R. Garro.1,2

    1Children's Healthcare of Atlanta, Atlanta, GA; 2Department of Pediatric Nephrology, Emory University, Atlanta, GA.

    Background: The incidence of new-onset diabetes after kidney transplantation (NODAT) in the pediatric population has not been well characterized. Early recognition of glucose intolerance may…
  • 2018 American Transplant Congress

    Early Postoperative Acute Kidney Injury among Pediatric Liver Transplant Recipients

    H. Sahinturk,1 A. Kundakci,1 P. Zeyneloglu,1 E. Gedik,1 A. Pirat,1 M. Haberal.2

    1Anesthesiology, Baskent University, Ankara, Turkey; 2Transplantation, Baskent University, Ankara, Turkey.

    Introduction: Acute kidney injury (AKI) after pediatric liver transplantation (LT) is a serious complication associated with increased morbidity and mortality. Here we evaluate children with…
  • 2018 American Transplant Congress

    Prevalence and Persistence of Cardiovascular Risk Factors and Subclinical Vascular Damage in Patients after Pediatric Lung Transplantation

    M. Onnen,1 N. Memaran,1 B. Borchert,1 R. Blöte,1 R. Sugianto,1 C. Müller,2 A. Melk.1

    1Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany; 2Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.

    In adults undergoing solid organ transplantation, cardiovascular (CV) disease causes a high level of morbidity and mortality. Children after lung transplantation (Lu-Tx) are prone to…
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