Articles tagged "Pediatric"

2018 American Transplant Congress
Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immunoregulatory Molecules Are Present in Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation
M. Sharma,¹ L. Danziger-Isakov,² P. Heeger,³ S. Sweet,⁴ T. Mohanakumar.¹
¹Norton Thoracic Insitute, St. Joseph's Hosp & Med Ctr, Phoenix; ²Cincinnati Children's Hosp Med Ctr, Cincinnati; ³Icahn Sch Med at Mt Sinai, New York; ⁴Washington Univ Sch Med, St. Louis.
Exosomes containing mismatched donor HLA and lung restricted self-antigens (SAgs), Kα1 Tubulin (Kα1T) and Collagen V (Col-V), have demonstrated in sera and bronchoalveolar lavage fluid…
2018 American Transplant Congress
Increasing Use of Exceptions after Changes to Pediatric Heart Allocation
A. Robinson,¹ W. Mahle,² R. Davies.³
¹United Network for Organ Sharing, Richmond, VA; ²Children's Healthcare of Atlanta, Atlanta, GA; ³Children's Medical Center of Dallas, Dallas, TX.
Purpose: Pediatric heart allocation in the United States was changed in 2016. The primary goal was to better align candidate status with waitlist mortality. Whether…
2018 American Transplant Congress
The Impact of Childhood Solid Organ Transplantation on B-Cell Maturation
L. Ionescu,¹ T. Blydt-Hansen,² B. Foster,⁷ S. Mital,³ L. Hamiwka,⁵ U. Allan,³ V. Phan,⁴ P. Birk,⁶ C. Morgan,¹ S. Urschel.¹
¹U of Alberta, Edmonton, Canada; ²U of BC, Vancouver, Canada; ³Hospital for Sick Children, Toronto, Canada; ⁴U de Montreal, Montreal, Canada; ⁵U of Calgary, Calgary, Canada; ⁶U of Manitoba, Winnipeg, Canada; ⁷McGill University, Montreal, Canada.
Background:The developing immune system of childhood promotes better graft acceptance and longevity but also higher risk for infections and post-transplant (Tx) lymphoproliferative disorders. This may…
2018 American Transplant Congress
Patient and Graft Survival in Pediatric Renal Transplant Recipients Compared to Adult Multi-Organ (Kidney-Pancreas, Simultaneous Liver-Kidney, or Heart-Kidney) Transplant Recipients: An Analysis of OPTN Data
P. Almond,¹ S. Al-Akash,¹ D. Stewart,² A. Robinson.²
¹CPSST Departments of Surgery and Renal Transplantation, Driscoll Children's Hospital, Corpus Christi, TX; ²UNOS, Richmond, VA.
Under the current kidney allocation system (KAS), pediatric (PED) renal transplant (RTx) candidates have a priority to kidneys from donors with KDPI <35%. However, multi-organ…
2018 American Transplant Congress
Prevalence of Abnormal Hemoglobin A1C in Pediatric Kidney Transplant Recipients
A. Serluco,¹ R. Liverman,¹ R. George,^1,2 R. Garro.^1,2
¹Children's Healthcare of Atlanta, Atlanta, GA; ²Department of Pediatric Nephrology, Emory University, Atlanta, GA.
Background: The incidence of new-onset diabetes after kidney transplantation (NODAT) in the pediatric population has not been well characterized. Early recognition of glucose intolerance may…
2018 American Transplant Congress
Early Postoperative Acute Kidney Injury among Pediatric Liver Transplant Recipients
H. Sahinturk,¹ A. Kundakci,¹ P. Zeyneloglu,¹ E. Gedik,¹ A. Pirat,¹ M. Haberal.²
¹Anesthesiology, Baskent University, Ankara, Turkey; ²Transplantation, Baskent University, Ankara, Turkey.
Introduction: Acute kidney injury (AKI) after pediatric liver transplantation (LT) is a serious complication associated with increased morbidity and mortality. Here we evaluate children with…
2018 American Transplant Congress
Prevalence and Persistence of Cardiovascular Risk Factors and Subclinical Vascular Damage in Patients after Pediatric Lung Transplantation
M. Onnen,¹ N. Memaran,¹ B. Borchert,¹ R. Blöte,¹ R. Sugianto,¹ C. Müller,² A. Melk.¹
¹Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany; ²Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
In adults undergoing solid organ transplantation, cardiovascular (CV) disease causes a high level of morbidity and mortality. Children after lung transplantation (Lu-Tx) are prone to…
2018 American Transplant Congress
Incidence of Epstein Barr Virus (EBV) DNAemia in EBV-Seronegative Solid Organ Transplant (SOT) Recipients with EBV-Seropositive Donors
C. Burton,¹ C. Mabilangan,² J. Preiksaitis.²
¹Pediatrics, University of Alberta, Edmonton, Canada; ²Medicine, University of Alberta, Edmonton, Canada.
Purpose: Since 2002, a pre-emptive approach to post-transplant lymhoproliferative disease prevention has been used at our center that includes EBV viral load (VL) monitoring in…
2018 American Transplant Congress
What's Normal? An Evaluation of Pediatric T Cell Markers in Healthy Controls
M. Sosniuk,¹ A. Halpin,^1,2,5,6,7 J. Wizniak,⁷ A. Szkotak,^6,7 S. Urschel,^1,2,5 L. Ionescu,^1,2,5 L. West.^1,2,3,4,5,6
¹Dept of Pediatrics, U of Alberta, Edmonton, Canada; ²Alberta Transplant Institute, Edmonton, Canada; ³Dept of MMI, U of Alberta, Edmonton, Canada; ⁴Dept of Surgery, U of Alberta, Edmonton, Canada; ⁵Canadian National Transplant Research Program, National, Canada; ⁶Dept of Laboratory Medicine, U of Alberta, Edmonton, Canada; ⁷Laboratory Medicine and Pathology, Alberta Health Services, Edmonton, Canada.
INTRODUCTION: Studying pediatric patients includes challenges such as difficulty obtaining samples, limited normal controls and small volumes. Standardized flow cytometry (FC) lymphocyte immunophenotyping panels are…
2018 American Transplant Congress
Transplantation of Very Small Pediatric En Bloc Renal Allografts from Donors Less Than 8 Months of Age Have Similar Outcomes to Donors More Than 8 Months
S. Aquil,^1,2,3 N. Mitrou,^1,3 V. McAlister,^1,2,3 A. Sener,^1,2,3 P. Luke.^1,2,3
¹Departments of Surgery and Transplant, London Health Sciences Centre, University Hospital, London, ON, Canada; ²Microbiology and Immunology and Matthew Mailing Center for Transplant Studies, London Health Sciences Centre, University Hospital, London, ON, Canada; ³Departments of Surgery and Transplant, Western University, London, ON, Canada.
Purpose: Few programs use kidneys from donors with body weight (BW) less than 10 kg or less than 8 months of age, for fear of…