Articles tagged "Pediatric"

2018 American Transplant Congress
Outcomes of Renal Transplantation in Pediatric Patients with VACTERL Association
J. Diaz,¹ B. Chavers,² S. Chinnakotla,³ P. Verghese.²
¹Medical School, University of Minnesota, Minneapolis, MN; ²Pediatric Nephrology, University of Minnesota, Minneapolis, MN; ³Transplant Surgery, University of Minnesota, Minneapolis, MN.
In this single-center retrospective review, we studied transplant outcomes in nine pediatric patients with VACTERL association, making this the largest study of its kind. Of…
2018 American Transplant Congress
Efficacy and Safety of Immediate- and Prolonged-Release Tacrolimus in De Novo Pediatric Transplantation: Randomized Study
K. Vondrak,¹ F. Parisi,² A. Dhawan,³ R. Grenda,⁴ N. Webb,⁵ S. Marks,⁶ D. Debray,⁷ R. Holt,⁸ A. Lachaux,⁹ D. Kelly,¹⁰ G. Kazeem,¹¹ N. Undre.¹¹
¹University Hospital Motol, Prague, Czech Republic; ²Osp Pediatrico Bambino Ges[ugrave], Rome, Italy; ³King's College Hospital, London, United Kingdom; ⁴The Children's Memorial Health Institute, Warsaw, Poland; ⁵Manchester University Foundation Trust, Manchester, United Kingdom; ⁶Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; ⁷APHP-Hôpital Universitaire Necker, Paris, France; ⁸Alder Hey Children's Hospital, Liverpool, United Kingdom; ⁹Université Lyon 1 et Hospices Civils de Lyon, Lyon, France; ¹⁰Birmingham Children's Hospital, Birmingham, United Kingdom; ¹¹Astellas Pharma Europe Ltd, Chertsey, United Kingdom.
This study assessed long-term efficacy/safety of prolonged-release tacrolimus (PR-T) vs immediate-release tacrolimus (IR-T) in de novo pediatric transplant pts. Phase II, parallel-group, multicenter, open-label study…
2018 American Transplant Congress
Barriers and Disparities in Listing for Pediatric Solid Organ Transplant
E. A. Steinberg,¹ C. Buchanan,¹ M. Wachs,¹ S. Schmiege.²
¹Univ. of Colorado School of Medicine/Children's Hospital Colorado, Aurora, CO; ²Colorado School of Public Health, Aurora.
Purpose The WHO recommends equitable access to transplant, yet disparities in listing based on gender, race, and education exist in adults. There is little research…
2018 American Transplant Congress
Assessment and Outcomes of Medication Nonadherence in Pediatric Kidney Transplant Recipients: Results from the IMPACT Study
A. Dokras,¹ M. Pearl,¹ J. Peipert,¹ P. Grimm,⁴ B. Warshaw,² E. Chambers,³ A. Kirk,³ R. Ettenger.¹
¹University of California, Los Angeles, Los Angeles, CA; ²Children's Healthcare of Atlanta and Emory University, Atlanta, GA; ³Duke University, Durham, NC; ⁴Stanford University, Palo Alto, CA.
OBJECTIVE: Medication nonadherence (MNA) plays a key role in transplant (Tx) survival in pediatric kidney patients (pts). However, identification of MNA is challenging and tools…
2018 American Transplant Congress
Information Needs of Adolescent Transplant Recipients Transitioning to Adult Care
B. Kosmach-Park,¹ D. Shellmer,² C. Nguyen,³ G. Mazariegos.²
¹Department of Transplant Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ²Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ³Department of Pediatric Nephrology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Background: As adolescent and young adult (AYA) tx recipients transition to adulthood, a parallel transition in care is essential. The AYA should achieve skills for…
2018 American Transplant Congress
Single-Dose Pharmacokinetics and Pharmacodynamics of Belatacept in Adolescent Kidney Transplant Recipients
A. Moudgil,¹ V. Dharnidharka,² D. Feig,³ B. Warshaw,⁴ V. Perera,⁵ B. Murthy,⁵ M. Roberts,⁵ M. Polinsky,⁵ R. Ettenger.⁶
¹Children's National Medical Center, Washington, DC; ²Washington University, St. Louis, MO; ³University of Alabama, Birmingham, AL; ⁴Emory University & Children's Healthcare of Atlanta, Atlanta, GA; ⁵Bristol-Myers Squibb, Lawrenceville, NJ; ⁶University of California, Los Angeles, CA.
Purpose: To assess the pharmacokinetics (PK) and pharmacodynamic (PD) effect of a single dose of belatacept (bela) administered to adolescent kidney transplant recipients (KTR).Methods: In…
2018 American Transplant Congress
Assessment of Anti-CMV Immunity by Monitoring Anti-CMV Antibody (CMV-Ab) and CMV-Specific Cytotoxic T Cells (CMV-Tc) in Pediatric Kidney Transplant Recipients (Ped KTx Pts)
B. Shin,¹ H. Pizzo,² S. Jordan,² D. Lovato,¹ A. Petrosyan,¹ D. Puliyanda,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: CMV infection results in significant morbidity in KTx pts, especially CMV sero- ped pts with CMV sero+ donors (D+/R-). CMV infection is controlled primarily…
2018 American Transplant Congress
Oral Health Related Quality of Life for Children with Kidney Disease
P. Verghese,¹ J. Sotillo,² J. Diaz,¹ E. Sarwas.²
¹Department of Pediatrics, University of Minnesota, Minneapolis; ²University of Minnesota Dental School, Minneapolis.
Children with kidney disease experience general health deficiencies that may affect their oral health and consequently their quality of life (QOL). Recent studies show a…
2018 American Transplant Congress
De Novo Donor Specific Antibodies in Pediatric Kidney Transplant Recipients Are Highly Responsive to Therapy
V. Sigurjonsdottir, P. Grimm.
Pediatric Nephrology, Lucile Packard Children´s Hospital, Palo Alto, CA.
Background: Pediatric Kidney transplant recipients who develop dnDSAs are at increased risk of allograft loss and rapid decline in GFR. C1q+ DSA, in particular, is…
2018 American Transplant Congress
Low Kidney Supply to Demand Ratio and Multi-Organ Transplant Centers Are Negatively Associated with Pediatric Renal Transplant Rates Post Kidney Allocation System Implementation: An Analysis of OPTN Data
P. Almond,¹ S. Al-Akash,¹ D. Stewart,² A. Robinson.²
¹CPSST Departments of Surgery and Renal Transplantation, Driscoll Children's Hospital, Corpus Christi, TX; ²UNOS, Richmond, VA.
Under the new kidney allocation system (KAS), pediatric (PED) renal (REN) transplant (Tx) candidates have priority to kidneys from donors with KDPI < 35%. We…