Articles tagged "Pediatric"

2020 American Transplant Congress
A Multicenter, Randomized, Controlled Trial to Steer Immunosuppressive Therapy by Virus-Specific T Cells after Pediatric Kidney Transplantation (IVIST-Trial)
T. Ahlenstiel-Grunow¹, A. Großhennig¹, R. Schild², J. Oh², C. Taylan³, L. Weber³, H. Staude⁴, M. Verboom¹, C. Schröder¹, R. Sabau¹, A. Koch¹, X. Liu¹, L. Pape¹
¹Hannover Medical School, Hannover, Germany, ²University Hospital Hamburg-Eppendorf, Hamburg, Germany, ³University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany, ⁴University Hospital of Rostock, Rostock, Germany
*Purpose: Pharmakokinetic monitoring of immunosuppressants alone is insufficient to estimate the individual intensity of immunosuppression after kidney transplantation (Tx). Virus-specific T cells (Tvis) correlate with…
2019 American Transplant Congress
Increase in 48 Month Cumulative Acute Rejection Rates in the Most Recent Cohort: The 2018 Transplant Report of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS)
V. Dharnidharka¹, C. Cramer², A. Chua³, A. Moudgil⁴, K. Martz⁵, T. Blydt-Hansen⁶, J. Smith⁷, A. Neu, on Behalf of The NAPRTCS Investigators⁸
¹Washington University in St. Louis, Saint Louis, MO, ²Mayo Clinic, Rochester, MN, ³Duke University, Durham, NC, ⁴Children's National Medical Center, Washington, DC, ⁵Emmes Corporation, Rockville, MD, ⁶BC Children's Hospital, Vancouver, BC, ⁷Seattle Children's Hospital, Seattle, WA, ⁸Johns Hopkins University, Baltimore, MD
*Purpose: The NAPRTCS registry has collected data on children receiving kidney transplants in North America since 1987. The registry has served to document and influence…
2019 American Transplant Congress
Hepatoblastoma Tumors Requiring Liver Transplantation Manifest Dysregulated Ciliary, Autophagy and Cell Cycling Pathways in Systems Biology Analysis
T. Narayanan¹, M. Ningappa², B. W. Higgs², S. Subramaniam³, R. Sindhi²
¹Bioenginering, University of California, San Diego, CA, ²Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ³University of California, San Diego, CA
*Purpose: Liver transplantation (LT) can cure locally invasive, unresectable and chemo-resistant hepatoblastoma (HBL), an embryonal liver tumor of infancy. Post-LT immunosuppression enhances recurrence-risk despite chemotherapy.*Methods:…
2019 American Transplant Congress
Hit Me with Your Best Shot! Multidisciplinary Team Approach to Live Vaccination Administration in Pediatric Transplant Candidates
H. Corbo, K. Sprott, N. Pilch, K. Twombley, D. Taber
Medical University of South Carolina, Charleston, SC
*Purpose: Pre-transplant live vaccination rates are suboptimal in pediatric patients with end-stage organ disease. Ensuring live vaccine administration prior to transplant (txp) confers the best…
2019 American Transplant Congress
Long-Term Outcome and Surgical Complications Following Live-Donor Kidney Transplantation in Children Weighting Less Than 15 Kg: A Single Center Experience in Japan
Y. Aoki¹, H. Satoh², Z. Matsui², R. Hamada³, R. Harada³, M. Muramatsu⁴, Y. Hamasaki⁴, S. Shishido⁴
¹Urology and Kidney Transplantation, Tokyo Metropolitan Children’s Medical Center, Fuchu-shi, Tokyo, Japan, ²Urology and Kidney Transplantation, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan, ³Nephrology, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan, ⁴Nephrology, Toho University Faculty of Medicine, Tokyo, Japan
*Purpose: Kidney transplantation (KTx) is considered more technically challenging in small children, incurring a higher risk of potential surgical and vascular complications. Intraperitoneal approach of…
2019 American Transplant Congress
Incidence of De Novo Donor Specific Antibodies and Treatment Response for AMR in Pediatric Kidney Transplant Recipients
S. Gattis¹, R. Liverman¹, A. Serluco¹, J. Yin¹, H. C. Sullivan², R. A. Bray³, H. M. Gebel³, S. Jernigan⁴, R. George⁴, P. D. Winterberg⁴, R. Garro⁴
¹Children's Healthcare of Atlanta, Atlanta, GA, ²Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, ³Emory University Hospital, Atlanta, GA, ⁴Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
*Purpose: Antibody-mediated rejection (AMR) is a significant complication in renal transplant patients. The aim of this study was to evaluate the incidence of de novo…
2019 American Transplant Congress
Epstein Barr Virus (EBV)-Specific T Cells as a Diagnostic Marker for the Individual EBV-Specific Immune Response after Pediatric Kidney Transplantation
T. Ahlenstiel-Grunow, L. Pape
Pediatric Nephrology, Hannover Medical School, Hannover, Germany
*Purpose: After transplantation immunosuppressive therapy causes an impaired cellular immune response resulting in an increased risk of EBV-associated complications, e.g. post-transplant lymphoproliferative disease (PTLD). Prognostic…
2019 American Transplant Congress
Long-Term Outcomes of Early Conversion to Sirolimus-Based Immunosuppression in Children with Living Donor Kidney Transplants
B. Stotter¹, S. Lui¹, E. Weller², L. Ganapathi¹, M. Ferguson¹, A. Traum¹, M. Somers¹, N. Rodig¹
¹Pediatrics, Boston Children's Hospital, Boston, MA, ²Biostatistics and Research Design Center, Boston Children's Hospital, Boston, MA
*Purpose: Following kidney transplantation (KTx), calcineurin inhibitor (CNI)-based maintenance immunosuppression (IS) can be associated with nephrotoxicity and other complications including viral infections and malignancy. Mammalian…
2019 American Transplant Congress
The Utility of Donor and Recipient BK Virus Antibody Testing Prior to Renal Transplantation in Risk Assessment for Developing BK Viremia
N. Donmez, S. I. Al-Akash
Driscoll Children's Hospital, Corpus Christi, TX
*Purpose: The correlation between donor (DON) and recipient (REC) BKV antibody (AB) titers and BK viremia in renal transplant (RTx) has not been well-studied in…
2019 American Transplant Congress
En Bloc Kidney Transplant from Infant Donors Less Than 5kg into Adult Recipients
Z. Wang, Q. Xia, M. Wang, H. Li, J. Liu, J. Liu, J. Liu
Urology, Union hospital, Wuhan, China
*Purpose: To explore the feasibility of en bloc kidney transplantation from infant donors less than 5kg into adult recipients.*Methods: A retrospective analysis was conducted of…