Articles tagged "Pediatric"

2021 American Transplant Congress
Use of Donor-Derived Cell-Free DNA in Children with Kidney Transplantation: A Pilot Study
E. Winnicki, J. Brennan, M. McEnhill, P. Brakeman, E. Ku
UCSF, San Francisco, CA
*Purpose: Use of a blood test to detect donor-derived cell-free DNA (dd-cfDNA) levels has been shown to predict rejection in adults with kidney transplants. If…
2021 American Transplant Congress
Early Detection of SARS-CoV-2 and Other Infections in Solid Organ Transplant Recipients and Household Members Using Wearable Devices
E. H. Li¹, E. Mukhtar¹, E. D. Elftmann¹, F. R. Eweje¹, H. Gao¹, L. I. Ibrahim¹, R. G. Kathawate¹, A. C. Lee¹, K. A. Moore¹, N. Nair¹, S. Amaral², M. Snyder³, B. J. Keating¹
¹Department of Surgery, Penn Transplant Institute, Division of Transplantation, Philadelphia, PA, ²Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Department of Genetics, Stanford University, Palo Alto, CA
*Purpose: Wearable devices that measure physiological parameters have shown utility for detecting infections such as influenza and recently COVID-19 up to 10 days before clinical…
2021 American Transplant Congress
A Comparison of Pediatric Intestine Transplant Between the Current Era (2015-2019) and the Peak Period (2002-2006)
S. Horslen¹, T. Weaver², M. Skeans²
¹Seattle Children's Hospital, Seattle, WA, ²SRTR, Minneapolis, MN
*Purpose: Demand for intestine transplants in children grew from its clinical inception in the late 1980s to a peak in 2007 of 111 small bowel-containing…
2021 American Transplant Congress
Impact of Once-Daily Extended-Release Tacrolimus Intrapatient Variability in Stable Adolescent and Young Adult Renal Transplant Recipients – 3 Year Results
M. M. Chandran¹, E. Blanchette¹, J. Goebel², M. Bock¹
¹Children's Hospital Colorado, Denver, CO, ²Helen DeVos Children’s Hospital, Grand Rapids, MI
*Purpose: Successful renal transplantation requires complex medication regimens that rely heavily on strict adherence to be effective. Variability in immunosuppression exposure, specifically tacrolimus, is associated…
2021 American Transplant Congress
Native Nephrectomy in Pediatric Kidney Transplant Recipients
D. Yoeli¹, A. Sater¹, A. Peace¹, M. E. Wachs¹, M. Bock², M. A. Adams¹
¹Transplant Surgery, Children’s Hospital Colorado, Aurora, CO, ²Pediatric Nephrology, Children’s Hospital Colorado, Aurora, CO
*Purpose: Data on native nephrectomy in children with renal disease requiring kidney transplantation is scarce. The aim of this study was to characterize demographics and…
2021 American Transplant Congress
Racial and Ethnic Disparities in Pediatric Kidney Transplantation – Has KAS Made a Difference?
O. Charnaya¹, S. Yu², A. Goldberg³, J. Garonzik-Wang², D. Segev², P. Verghese⁴
¹Pediatrics, Johns Hopkins University, Baltimore, MD, ²Transplant Surgery, Johns Hopkins University, Baltimore, MD, ³University of Manitoba, Winninpeg, MB, Canada, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Racial and ethnic minority pediatric transplant candidates have known disparities in access to kidney transplantation. The Kidney Allocation System (KAS), implemented in 2014, was…
2021 American Transplant Congress
Adenovirus-Specific T Cells for Steering of Immunosuppression After Pediatric Kidney Transplantation in the Randomized Controlled Ivist Trial
T. Ahlenstiel-Grunow¹, X. Liu², R. Schild³, J. Oh³, C. Taylan⁴, L. T. Weber⁴, H. Staude⁵, M. Verboom⁶, C. Schröder⁷, R. Sabau⁷, A. Großhennig², L. Pape¹
¹Pediatrics II, University Hospital of Essen, Essen, Germany, ²Institute of Biostatistics, Hannover Medical School, Hannover, Germany, ³Pediatric Nephrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, ⁴Pediatric Nephrology, University of Colgne, Köln, Germany, ⁵Pediatric Nephrology, University Hospital of Rostock, Rostock, Germany, ⁶Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany, ⁷Institute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany
*Purpose: Pharmacokinetic monitoring alone is insufficient to estimate the intensity of immunosuppression after pediatric kidney transplantation (Tx). Levels of virus-specific T cells (Tvis) have been…
2021 American Transplant Congress
Longitudinal Studies of Blood Donor-derived Cell Free DNA (dd-cfDNA) Show Predictable Rise at Time of BK Viremia or Viruria in Pediatric Kidney Transplant Recipients (PKTx)
R. Dandamudi¹, H. Gu¹, C. Goss¹, S. Federman², R. Woodward², S. Dholakia², L. Walther¹, V. Dharnidharka¹
¹Washington University in St Louis, St. Louis, MO, ²CareDx, Brisbane, CA
*Purpose: Blood levels of dd-cfDNA elevate in various forms of kidney transplant injury, most notably used for detecting potential acute rejection. A few adult studies,…
2021 American Transplant Congress
Food Insecurity and Impact on Transplant Outcomes in Pediatric Kidney Transplant Recipients
A. Moin, P. Verghese, R. Engen, D. Matossian
Pediatric Nephrology, Lurie Children's Hospital, chicago, IL
*Purpose: Food insecurity (FI), defined as inconsistent access to food or worry over shortage of food that prevents an active and healthy life, has not…
2021 American Transplant Congress
Kidney Paired Donation in Pediatrics: An Underused Opportunity?
J. Smith¹, M. Skeans², R. Engen³, S. Bartosh⁴
¹Seattle Children's Hospital, Seattle, WA, ²SRTR, Minneapolis, MN, ³Lurie Children's Hospital, Chicago, IL, ⁴Univ of Wisconsin, Madison, WI
*Purpose: Kidney paired donation (KPD) provides the opportunity for ABO-mismatched or HLA-incompatible pairs to receive a living donor kidney transplant. The superior graft survival among…