Articles tagged "Panel reactive antibodies"

2020 American Transplant Congress
Association between Homograft Tissue Exposure and Pre-Sensitization Prior to Heart Transplant in Patients with Congenital Heart Disease
D. J. Donovan¹, M. E. Richmond², E. A. Bacha³, L. J. Addonizio², W. A. Zuckerman²
¹Pediatrics, NewYork-Presbyterian Hospital, Columbia University Irving Medical Center, New York, NY, ²Pediatric Cardiology, NewYork-Presbyterian Hospital, Columbia University Irving Medical Center, New York, NY, ³Pediatric Cardiac Surgery, NewYork-Presbyterian Hospital, Columbia University Irving Medical Center, New York, NY
*Purpose: Surgical repair for patients with congenital heart disease (CHD) often incorporates homograft tissue or other biologic material, which can lead to pre-sensitization. We sought…
2020 American Transplant Congress
Third and Fourth Kidney Re-Transplants: A 20-Year Single Centre Experience
O. O. Okidi¹, A. Hassan¹, S. Bhutani¹, A. Summers¹, K. Poulton², C. Fullwood¹, D. VanDellen¹, J. Worthington², T. Augustine¹
¹Transplant and Endocrine Surgery, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom, ²Transplantation Laboratory, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom
*Purpose: Re-transplantation may be associated with management dilemmas including repeat allocation of limited kidney allografts to same individuals in the face of an increasing waiting…
2020 American Transplant Congress
A Single-Center Analysis of Using Allele-Level 11 HLA Loci Information on cPRA and Organ-Allocation Points in Kidney Transplant Candidates
C. Maguire¹, P. Muluhngwi¹, E. Kransdorf², L. Gragert³, A. R. Tambur¹
¹Northwestern University, Chicago, IL, ²Cedars-Sinai Heart Institute, Beverly Hills, CA, ³Tulane University, New Orleans, LA
*Purpose: Calculated panel reactive antibodies (cPRA) is used by the United Network for Organ Sharing (UNOS) to quantify degree of HLA sensitization and assign priority…
2020 American Transplant Congress
The Natural History of Waitlist Candidates in the United States
A. Massie¹, D. Segev²
¹Johns Hopkins School of Medicine, Baltimore, MD, ²Johns Hopkins, Baltimore, MD
*Purpose: Estimates of time to deceased-donor transplantation (DDKT) generally fail to take into account the competing risks of mortality. Understanding the natural history of KT…
2019 American Transplant Congress
Transplantation of the Highly Sensitized Renal Transplant Candidate in the Post-KAS Era: Who is Left Out?
C. Schinstock, B. Smith, A. Bentall, M. Stegall
Mayo Clinic, Rochester, MN
*Purpose: Highly sensitized kidney transplant candidates are given high priority under the new kidney allocation system (KAS), but it is unclear if all sensitized candidates…
2019 American Transplant Congress
Optimizing Opportunity and Benefits of Steroid Avoidance in the New KAS Era
S. Sultan, M. Aull, R. Friedlander, V. K. Sharma, D. Serur, A. Watkins, S. Kapur, D. Dadhania
New York Presbyterian / Weill Cornell, New York, NY
*Purpose: The introduction of the new Kidney Allocation System (KAS) in 2014 has facilitated transplantation of sensitized patients with high CPRA. However, the CPRA value…
2019 American Transplant Congress
Overcoming Anti-HLA Sensitization in Kidney Transplantation
R. C. Siqueira¹, P. Malafronte², J. C. Baptista-Silva², E. F. Silva², M. C. Camargo², M. C. Ribeiro Castro²
¹Nephrology Post-Graduation, University of Sao Paulo, São Paulo, Brazil, ²Kidney Transplant Unit, Hospital Samaritano de São Paulo, São Paulo, Brazil
*Purpose: To evaluate if it is possible to achieve good results in kidney transplantation (Ktx) regardless the degree of anti-HLA sensitization.*Methods: 143 adult living (LD)…
2019 American Transplant Congress
Panel Reactive Antibody Stratification as a Guide to Induction Selection in Deceased-Donor Kidney Transplantation: Impact of Clinical Practice on Outcomes
H. Ibrahim¹, J. Gregg¹, K. Alquadan¹, U. Akanit², K. L. Womer¹, A. H. Santos¹
¹Medicine, University of Florida, Gainesville, FL, ²Ubon Ratchathani University, Ubonratchathani, Thailand
*Purpose: We aimed to determine the outcomes associated with anti-thymocyte globulin (ATG), alemtuzumab (ALM) or interleukin-2 receptor antagonist (IL2-RA) induction in adult deceased-donor (DD) kidney…
2019 American Transplant Congress
International Multicenter Study Evaluating Clinical Outcomes Associated with Acute Antibody-Mediated Rejection
S. Corman¹, I. Hirji², E. Brouwer², S. H. Park¹, C. Macahilig³, A. Vergani², T. Bo², P. Wolthoff³, P. Keown⁴
¹Pharmerit International, Bethesda, MD, ²Shire, Cambridge, MA, ³Medical Data Analytics, Parsippany, NJ, ⁴University of British Columbia, Vancouver, BC, Canada
*Purpose: Evaluating factors that impact clinical outcomes of patients with acute antibody-mediated rejection (aAMR) may help manage and improve outcomes following kidney transplant. The objective…
2019 American Transplant Congress
A Clinical Analysis for Low-Dose Immunoglobulin United with Plasmapheresis in High Sensitization Renal Transplantation Recipients
L. Xu¹, J. Zhang²
¹Chinese PLA General Hospital Eighth Medical Centre, Beijing, China, ²Nursing Department, Chinese PLA General Hospital, Beijing, China
*Purpose: To analyze the role of low-dose intravenous immunoglobulin (IVIG) united with plasmapheresis in high sensitization renal transplantation recipients.*Methods: Four patients with high levels of…