Articles tagged "Pancreatitis"

2019 American Transplant Congress
Outcomes of Total Pancreatectomyand Islet Autotransplantation, a Single Center Experience
A. Rajab¹, J. Buss¹, L. F. Lara², S. Meng³, K. Kuntz⁴, D. Conwell², P. A. Hart², K. Washburn¹
¹Transplant Surgery, The Ohio State University, Columbus, OH, ²Gastroenterology, Hepatology and Nutrition, The Ohio State University, Columbus, OH, ³Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, ⁴Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH
*Purpose: Patients with chronic pancreatitis (CP) suffer from severe pain that greatly reduces their quality of life and often leads to long-term narcotic therapy to…
2018 American Transplant Congress
NFkB Inhibitor Improves Glycemic Control after Syngeneic Islet Transplantation by Suppression of Proinflammatory and Apoptotic Gene Expression in a Cerulein-Induced Pancreatitis Model
G. Yoshimatsu,¹ C. Darden,² K. Kumano,² C. Chang,² P. Saravanan,² M. Lawrence,² B. Naziruddin.³
¹Fukuoka University, Fukuoka, Japan; ²Baylor Scott and White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis. Repeated or continuous pancreatitis attack leads islet damage beyond inflamed exocrine…
2018 American Transplant Congress
Early Predictors of Metabolic Outcomes in TPIAT
M. Kanak,¹ Y. Shindo,¹ M. Levy.^1,2
¹Surgery, Virginia Commonwealth University, Richmond, VA; ²Hume-Lee Transplant Center, VCU Health System, Richmond, VA.
BackgroundTotal Pancreatectomy with Islet Auto-transplantation (TPIAT) has been actively performed on patients with severe, debilitating pain of chronic pancreatitis or recurrent acute pancreatitis. It is…
2018 American Transplant Congress
Obese Patients Show Resistance to Narcotics Reduction after TPIAT for Chronic Pancreatitis
G. Yoshimatsu,¹ B. Naziruddin,³ K. Kumano,² H. Fernandez,³ E. Beecherl,³ N. Onaca.³
¹Fukuoka University, Fukuoka, Japan; ²Baylor Scott and White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for chronic pancreatitis patients with refractory pain. Patients with high BMI (>30) are known…
2017 American Transplant Congress
Assessment of Islet Damage During Isolation Utilizing miRNAs and Its Significance with Post-Transplant Outcome in TPIAT.
P. Saravanan,¹ M. Kanak,² G. Yoshimatsu,¹ M. Lawrence,¹ B. Naziruddin.³
¹Baylor Scott and White Research Institute, Dallas, TX; ²Virginia Commonwealth University, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX
Background: Pancreatic islets with high quality are essential for better endocrine function and post-transplant outcome in total pancreatectomy with islet autotransplantation (TPIAT). The islets are…
2017 American Transplant Congress
Improved Method to Obtain High Islet Mass from Severely Fibrotic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation.
A. Balamurugan, G. Loganathan, W. Tucker, M. Dhanasekaran, S. Narayanan, A. Patel, S. Mokshagundam, S. Williams, M. Hughes.
Clinical Islet Laboratory, Dept. of Surgery, Cardiovascular Innovation Institute, University of Louisville, KY
A total pancreatectomy and islet autotransplant (TPIAT) offers substantial pain relief and improved quality of life for pancreatitis patients. Isolating a large quantity of islet…
2017 American Transplant Congress
Impact of Pancreatic Texture Assessment on Islet Isolation and Metabolic Outcome After TPIAT.
G. Yoshimatsu,¹ M. Khadka,¹ M. Lawrence,¹ B. Appakalai,² B. Naziruddin.³
¹Baylor Scott and White Research Institute, Dallas, TX; ²University of Louisville, Louisville, KY; ³Baylor Simmons Transplant Institute, Dallas, TX
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis (CP). Chronic inflammation leads to fibrosis formation in pancreas and…
2017 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation Improves Quality of Life Allowing for the Resolution of the Intractable Pain with Good Glucose Control in Properly Selected Patients with Chronic Pancreatitis.
A. Kotukhov,¹ J. Solomina,¹ E. Konsur,¹ K. Cieply,¹ L. Basto,¹ L.-J. Wang,¹ K. Golab,¹ M. Tibudan,¹ A. Gelrud,² C. Thomas,² J. Matthews,¹ P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Medicine, University of Chicago, Chicago, IL
Background: There is a group of Total pancreatectomy (TP) is offered as a last option to patients with chronic pancreatitis (CP) who despite optimal treatment…
2017 American Transplant Congress
Initial Experince with Total Pancreatectomy-Islet Auto-Transplantation (TP-IAT) for Chronic Pancreatitis at the University of Louisville.
M. Hughes,¹ E. Davis,¹ S. Mokshagundam,² W. Tucker,¹ G. Logananthan,¹ S. Williams,³ B. Appakalai.¹
¹Surgery, University of Louisville, Louisville, KY; ²Medicine, University of Louisville, Louisville, KY; ³Physiology, University of Louisville, Louisville, KY
Chronic pancreatitis (CP) represents a highly significant healthcare challenge in Kentucky. To address this need, we created a TP-IAT program to cure patients of this…
2016 American Transplant Congress
MicroRNA-375 and -200c Are a Set of Novel Biomarkers That Can Predict Islet Autotransplantation Outcome.
G. Yoshimatsu,¹ M. Kanak,² M. Takita,¹ S. Prathab Balaji,¹ C. Chang,¹ M. Lawrence,¹ M. Levy,² N. Onaca,³ P. Kim,³ B. Naziruddin.³
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Transplant Division, Department of Surgery, VCU Medical Center, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractive chronic pancreatitis to relieve pain and retain endocrine function. Patient selection is…