Articles tagged "non-heart-beating"

2018 American Transplant Congress
Intensified Immunosuppression Improves Early Renal Allograft Function after Transplantation in a Porcine Model with Extended Asystolic Warm Ischemic Time
M. Xu,¹ X. Wang,¹ S. Garcia-Aroz,¹ B. Banan,¹ B. Rabe,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ P. Manning,² J. Gaut,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO; ²Arch Oncology, St. Louis, MO; ³Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
PURPOSE: Extensive ischemia-reperfusion injury significantly increases the immunogenicity of renal allograft which may be associated with increased risk of acute rejection (AR). This study investigated…
2018 American Transplant Congress
Outcomes of Donation after Cardiac Death Liver Grafts from Donors ≥ 50 Years of Age: A Multi-Center Analysis
K. P. Croome,¹ A. K. Mathur,³ D. D. Lee,¹ A. A. Moss,³ C. B. Rosen,² J. K. Heimbach,² C. B. Taner.¹
¹Mayo Clinic Florida, Jacksonville, FL; ²Mayo Clinic Rochester, Rochester, MN; ³Mayo Clinic Arizona, Scottsdale, AZ.
Introduction:As the population in the United States continues to age, an increase in the number of potential DCD donors with advanced chronological age can be…
2018 American Transplant Congress
Superior Outcomes Using Normothermic Regional Perfusion in CDCD Liver Transplantation
A. Hessheimer, E. Coll, A. Valdivieso, M. Gómez, J. Santoyo, P. Ramírez, M. Gómez-Bravo, R. López-Andujar, J. Villar, C. Jiménez, F. Lluís, L. Lladó, D. Casanova, M. Barrera, R. Charco, J. López-Baena, J. Briceño, F. Pardo, G. Blanco, D. Pacheco, B. Domínguez-Gil, V. Sánchez-Turrión, C. Fondevila.
Spanish Liver Transplant Registry, Spanish Society of Liver Transplantation, Madrid, Spain.
While there is increasing interest in its use, definitive evidence demonstrating superiority of normothermic regional perfusion in controlled donation after circulatory death liver transplant has…
2018 American Transplant Congress
Comparison of Continuous Normothermic Ex Vivo Kidney Perfusion to Hypothermic Preservation Methods in Pig Kidneys Donated after Cardiac Death
M. Hamar,^1,2 P. Urbanellis,¹ D. Kollmann,¹ I. Linares,¹ M. Kaths,¹ D. Bagli,³ A. Konvalinka,⁴ I. Mucsi,¹ A. Ghanekar,¹ L. Robinson,² M. Selzner.¹
¹Multi Organ Transplant Program, TGH, Toronto, ON, Canada; ²Division of Nephrology, The Hospital of Sick Children, Toronto, ON, Canada; ³Dept. of Surgery (Urology) & Physiology, The Hospital of Sick Children, Toronto, ON, Canada; ⁴Dept. of Medicine and Institute of Medical Science, UHN and Univ. of Toronto, Toronto, ON, Canada.
Background: Strategies to decrease preservation-related injury in renal grafts donated after circulatory death urgently needed. This highlights the importance of direct comparison of dynamic preservation…
2018 American Transplant Congress
Livers from Diabetic Donors Can Safely Be Used in Donation after Circulatory Death Liver Transplantation
I. Brüggenwirth,¹ I. Vasiliauskaire,² A. Westerkamp,¹ W. Polak,² A. Braat,³ R. Porte.¹
¹Surgery, UMCG, Groningen, Netherlands; ²Surgery, Erasmus MC, Rotterdam, Netherlands; ³Surgery, LUMC, Leiden, Netherlands.
Liver grafts from donors with a history of diabetes mellitus (DM) have been associated with reduced graft survival after liver transplantation. Transplantation centers are often…
2018 American Transplant Congress
Impact of Donor Hepatectomy Time during Organ Procurement in Donation after Circulatory Death Liver Transplantation; The United Kingdom Experience
S. Farid, A. Magdy, D. Vijayanand, V. Upasani, S. Willis, A. Barlow, H. Ernest, A. Niaz.
St James University Hospital, Leeds, United Kingdom.
IntroductionNo data exists to evaluate the impact of hepatectomy time (HT) during donation after cardiac death (DCD) procurement on short and long-term outcomes following liver…
2018 American Transplant Congress
Human Atrial Natriuretic Peptide (hANP) in Cold Storage of Donation after Cardiac Death Livers: A New Tool for Protecting Vascular Endothelia?
Y. Nigmet,¹ K. Hata,¹ Y. Okamura,¹ I. Tamaki,¹ T. Tsuruyama,² H. Hirao,¹ T. Kubota,¹ J. Kusakabe,¹ J. Yoshikawa,¹ T. Goto,¹ T. Tajima,¹ H. Tanaka,¹ S. Uemoto.¹
¹Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University, Kyoto, Japan; ²Center for Anatomical, Pathological, and Forensic Medical Research, Kyoto University, Kyoto, Japan.
Aim: Current critical shortage of donor organs has led to acceptance of donation after cardiac death (DCD) livers for transplantation. Human atrial natriuretic peptide (hANP)…
2018 American Transplant Congress
Donation after Circulatory Death Donor Liver Transplantation without Ischemic Cholangiopathy: Is It Time to Expand DCD Liver Donor Pool?
C. Kubal,¹ P. Mihaylov,^1,2 B. Ekser,¹ A. Cabrales,¹ J. Fridell,¹ R. Mangus.¹
¹Transplant Surgery, Indiana University, Indianapolis; ²Division of General Surgery, IRCCS Policlinico San Matteo Foundation, University of Pavia, Lombardy, Italy.
Background: To prevent ischemic cholangiopathy (IC) after liver transplantation (LT), a protocol optimizing peri-operative conditions along with thrombolytic (tissue plasminogen activator) donor flush during DCD…
2018 American Transplant Congress
Hemodynamic and Functional Analysis of Human DCD Hearts Undergoing Normothermic Ex Vivo Perfusion
W. Sommer, N. Roy, S. Kilmarx, J. O., J. Titus, M. Villavicencio, J. Stone, J. Madsen, D. D'Alessandro.
Massachusetts General Hospital, Boston.
Heart donation after circulatory death (DCD) is feasible although little is known about the hemodynamic and functional parameters of these marginal donor organs. We conducted…
2018 American Transplant Congress
Predictive Scores for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation
C. Ding,^1,2 W. Xue,^1,2 P. Tian,^1,2 X. Ding,^1,2 X. Pan,^1,2 H. Xiang,^1,2 Y. Li,^1,2 X. Tian,^1,2 F. Han,^1,2 Q. Tai.^1,2
¹Department of Kidney Transplantation, Nephropathy Hospital, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; ²Institute of Organ Transplantation, Xi'an Jiaotong University, Xi'an, China.
Background Hypothermic machine perfusion (HMP) is increasingly being used in cardiac death kidney transplantation, but the value of assessing organ quality and predicting DGF through…