Articles tagged "Nerve allografts"

2022 American Transplant Congress
Enhancing Early Nerve Regeneration from Reconstruction of a Segmental Nerve Injury with Polyethylene Glycol
A. Bernal¹, C. Hinshaw¹, J. Hinshaw¹, C. Yang², S. Margaux¹, W. Zhang¹, J. Nuelle¹, C. Sabbag¹, G. Bittner², J. Shores³, E. Weitzel¹, J. Alderete¹
¹RESTOR FUSE Nerve Reconstruction Consortium, US Army Institute of Surgical Research/59th MDW, San Antonio, TX, ²University of Texas at Austin, Austin, TX, ³John Hopkins University, Baltimore, MD
*Purpose: Despite advancements in understanding and treating peripheral nerve injuries (PNIs), restoration of lost motor and sensory functions remain poor using current methods of clinical…
2022 American Transplant Congress
Tissue Edema Following Hypothermic Machine Perfusion of a Small Animal Hind Limb Graft
D. Yoeli, Y. Wang, B. Li, J. Huang, S. Jain, Z. Wang, N. Nakra, N. Limon De La Rosa, K. Rampalski, A. Su, D. Mathes, K. Washington, E. Farkash, A. Jani, C. Huang
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: The aim of this study was to evaluate the capability of preserving a small animal hind limb graft for 24 hours with hypothermic machine…
2022 American Transplant Congress
Evaluation of UW-Based Solutions Formulated to Be Anti-Apoptotic and Neuroprotective of Retinal Ganglion Cells (RGCs) Following Whole Eye Transplantation (WET) in a Rat Model
N. J. Khatter¹, Y. Wang¹, B. Li¹, C. R. Owens¹, A. H. Jani², C. A. Huang¹, R. W. Nickells³, A. A. Su¹, K. M. Washington¹
¹Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO, ²Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, ³Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI
*Purpose: As vascularized composite allotransplantation (VCA) of an intact optical system to restore vision requires overcoming RGC apoptosis caused by ischemia reperfusion injury, UW and…
2019 American Transplant Congress
Rejection Of Optic And Sciatic Transplants
M. Yonar¹, M. Uehara¹, V. Kasinath¹, F. Bei², R. Abdi¹
¹Renal, Brigham and Women's Hospital, Boston, MA, ²Neurosurgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Mechanisms of rejection of peripheral nerve and optic nerve remains largely unknown. The inability to prevent rejection of the optic nerve has thwarted the…
2018 American Transplant Congress
The Preclinical Application of the Tactile Discrimination Task in Rat Models
S-.H. Wu,^1,2 C-.J. Wen,^1,2 J-.J. Huang,^1,2,3 Y-.C. Pei,^1,2,3 C-.H. Lin,^1,2,4,5 H. Cheng,¹ Z-.L. Peng,^1,4,5 H-.I. Yang,⁶ F-.C. Wei.^1,2,5
¹Center for Vascularized Composite Allotransplantation, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²College of Medicine, Chang Gung University, Taoyuan, Taiwan; ³Department of Physical Medicine & Rehabilitation, Taoyuan Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁴Division of Trauma and Emergency Plastic Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁵Division of Plastic Reconstructive Microsurgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁶Department of Electronic Engineering, National Taipei University of Technology, Taipei, Taiwan.
Nerve reinnervation is an important issue in the field of vascularized composite allotransplantation (VCA). However, nowadays the effective treatment for enhancing the reinnervation after the…
2018 American Transplant Congress
Mayo Clinic's First Face Transplant: 17 Months On
H. Amer, S. Jowsey-Gregoire, C. Rosen, R. Razonable, K. Reid, M. Gandhi, L. Ewoldt, B. Edwards, S. Mardini.
The Essam and Dalal Obaid Reconstructive Transplant Center and the William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.
Mayo Clinic established a reconstructive transplant program as an extension of clinical practice in 2010. A 31-year-old Caucasian male had significant functional limitations and disfigurement…
2017 American Transplant Congress
Functional Mystacial Pad Allograft Tolerance Induced and Maintained by Vascularized Bone Marrow Transplant.
C.-H. Lin,^1,2 M. Anggelia,^1,2 C.-J. Wen,¹ W.-Y. Chuang,³ H.-Y. Cheng,¹ C.-H. Lin,^1,2 G. Brandacher.⁴
¹Department of PRS, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan; ³Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁴Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
Background: Accumulating findings indicate that vascularized bone marrow (VBM) transplantation plays a critical role to promote tolerance of vascularized composite allografts (VCA) without life-long immunosuppression.…
2015 American Transplant Congress
Rat Forelimb Allotransplantation: A Novel Microsurgical Model for Optimized Functional Assessment After Reconstructive Transplantation
B. Kern,¹ S. Tuffaha,¹ M. Khusheim,¹ S. Xiang,¹ G. Furtmueller,¹ K. Sarhane,¹ J. Park,² A. Hoke,² W. Lee,¹ G. Brandacher.¹
¹Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; ²Neurology and NeuroSurgery, Johns Hopkins University, Baltimore, MD.
Background:Functional outcomes following vascularized composite allotransplantation (VCA) have been promising, but there is still room for improvement. Studies to investigate strategies to overcome this obstacle…
2015 American Transplant Congress
Immunologic, Proangiogenic and Neurogenic Assessment of Allogenic Epineurium of the Human Peripheral Nerve for Potential Application in Prevention of Neuroma Formation
A. Klimczak,¹ K. Futoma,² A. Jundzill,³ D. Patrzalek,⁴ M. Siemionow.⁵
¹Clinical Immunology Department, Institute of Immunology and Experimental Therapy PAS, Wroclaw, Poland; ²Wroclaw Research Centre EIT+, Wroclaw, Poland; ³Regenerative Medicine Tissue Engineering Department, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland; ⁴Department of Surgery, 4th Military Clinical Hospital, Wroclaw, Poland; ⁵Department of Orthopaedics, The University of Illinois at Chicago, Chicago, IL.
Purpose: Transplantation of epineural sheath may support nerve regeneration after traumatic nerve injuries. Unsolved problem after nerve injury is painful neuroma formation. Natural biologic material,…
2015 American Transplant Congress
Mesenchymal Stem Cell Therapy to Improve Functional Outcome in Vascular Composite Allotransplantation (VCA)
S. Salgar, J. Bingham, M. DeHart, J. Tercero, T. Brown.
Madigan Army Medical Center, Tacoma.
Introduction: Although over 200 VCA including hand and face transplants have been performed worldwide with encouraging graft survival outcomes, long-term success with motor and sensory…