ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Nephrotoxicity"

  • 2020 American Transplant Congress

    Protective Effect of Fucoidan Against Tacrolimus-Induced Nephrotoxicity in LLC-PK1 Cells

    H. J. Jang

    Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of

    *Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
  • 2019 American Transplant Congress

    A Retrospective Observational Analysis of Tacrolimus Metabolism Rate: No Evidence for Impact on Renal Function

    A. J. Hughes, J. E. Kimpton, I. MacPhee

    Renal Medicine and Transplantation, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom

    *Purpose: A previous publication found that fast metabolisers of tacrolimus had inferior renal function compared to slow metabolisers in a Caucasian population (Thölking et al.,…
  • 2019 American Transplant Congress

    Monitoring And Management Of Proteinuria Is Often Ignored In Patients Receiving mTOR Therapy Following Orthotopic Liver Transplantation

    R. Kaur1, O. Sadiq2, M. Alimirah1, F. Kumssa1, A. Patel3, S. Jafri2

    1Internal Medicine, Henry Ford Hospital, Detroit, MI, 2Gastroenterology, Henry Ford Hospital, Detroit, MI, 3Nephrology, Henry Ford Hospital, Detroit, MI

    *Purpose: Use of mTOR inhibitors, such as Everolimus (EVL), in liver transplant (LT) patients continues to rise as the side effect profile becomes more evident.…
  • 2019 American Transplant Congress

    Renal Safety Of Entecavir And Tenofovir With Hepatitis B Immunoglobulin In Liver Transplant Patients

    D. Kim1, J. Lee1, E. Kim1, S. Kim1, K. Ihn1, D. Joo1, K. Huh1, B. Kim2, M. Kim1, S. Kim1, Y. Kim1, J. Lee1

    1Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, 2Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Combination of potent nucleos(t)ide analougues (NAs) and hepatitis B immunoglobulin is recommended after liver transplantation for the prevention of hepatitis B virus (HBV) recurrence.…
  • 2019 American Transplant Congress

    Eupatilin Ameliorates Tacrolimus Induced Nephrotoxicity via Inhibiting Apoptosis

    H. J. Jang, C. S. Park, M. Y. Oh

    Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of

    *Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
  • 2019 American Transplant Congress

    Low Incidence of Acute Renal Failure with Minimal Prophylaxis after Iodinated-Contrast TC in Ambulatory Renal Transplant Patients

    C. Jimenez1, S. Afonso1, M. O. Lopez1, M. E. Gonzalez1, M. J. Santana1, A. Santiago2, M. A. Vaca1, M. Ferreira1, R. Selgas1

    1Nephrology, Hospital Universitario La Paz, Madrid, Spain, 2Radiology, Hospital Universitario La Paz, Madrid, Spain

    *Purpose: Kidney transplant patients are at risk of contrast-induced nephropathy. CT scan with contrast is a very common imaging test. Our objective is to study…
  • 2019 American Transplant Congress

    Early Everolimus Conversion For Renal Protection In Liver Transplantation: The Sooner The Better?

    M. Tomeczkowicz, N. Sulejmani, A. Jantz, B. Summers, T. Larson, R. Salgia

    Henry Ford Health System, Detroit, MI

    *Purpose: Calcineurin inhibitors (CNI) are the mainstay of immunosuppressive therapy in transplantation; however, a major side effect limiting CNI use is nephrotoxicity. Mammalian target of…
  • 2019 American Transplant Congress

    Discovery and Validation of an Early Post-Transplant Biomarker Model Predictive of Chronic Kidney Disease in Liver Transplant Recipients

    J. Levitsky1, S. Asrani2, G. Klintmalm2, T. Schiano2, A. Moss3, K. Chavin4, C. Miller5, L. Zhao6, K. Guo6, N. Bridges7, J. Odim7, M. Brown7, D. Ikle8, B. Armstrong8, M. Abecassis9

    1Gastroenterology and Hepatology, Northwestern University, Chicago, IL, 2Baylor, Dallas, TX, 3Mayo Arizona, Phoenix, AZ, 4Case Western, Cleveland, OH, 5Cleveland Clinic, Cleveland, OH, 6Northwestern University, Chicago, IL, 7NIAID, Bethesda, MD, 8Rho, Chapel Hill, NC, 9Comprehensive Transplant Center, Northwestern University, Chicago, IL

    *Purpose: A significant proportion of patients develop chronic kidney disease after liver transplantation (LT). We aimed to develop clinical/protein models to predict future GFR deterioration…
  • 2019 American Transplant Congress

    Renal Failure as a Complication of Vascularized Composite Allotransplantation

    R. N. Barth1, J. T. Shores2, G. Brandacher2, M. H. Levine3, A. Weissenbacher4, A. J. Nam1, N. Shockcor1, E. D. Rodriguez5, S. Schneeberger4, W. Lee2, S. T. Bartlett1, L. Levin3

    1University of Maryland School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3University of Pennsylvania School of Medicine, Philadelphia, PA, 4Medical University Innsbruck, Innsbruck, Austria, 5New York University School of Medicine, New York, NY

    *Purpose: Vascularized composite allotransplantation (VCA) has demonstrated impressive outcomes in areas of extremity (UETx), face (FTx), genitourinary, and abdominal wall transplantation with up to twenty…
  • 2019 American Transplant Congress

    Clinical Implications of Belatacept Conversion in a High-Risk, Urban Renal Transplant Population

    B. Valdepenas, J. Benken, E. Benedetti, Z. Hajjiri, A. Lichvar

    University of Illinois at Chicago, Chicago, IL

    *Purpose: Conversion to belatacept as maintenance immunosuppression has gained traction to prevent calcineurin inhibitor (CNI) induced toxicities in renal transplant (RTx) recipients. However, limited knowledge…
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