Articles tagged "Negative selection"

2020 American Transplant Congress
Rare Genetic Mutation Triggering Acute Liver Failure in a Toddler Needing a Liver Transplant
C. B. Chen¹, N. Mistry Ambani¹, A. Zeft¹, R. Garcia-Naviero², V. Hupertz¹, K. Hashimoto¹, K. Radhakrishnan¹
¹Cleveland Clinic, Cleveland, OH, ²Akron Children's Hospital, Akron, OH
*Purpose: The AIRE gene plays an important role in immune tolerance by driving negative selection of self-recognizing T-cells. Mutations in this gene are responsible for…
2019 American Transplant Congress
MHC Cross-Dressing in Mixed Hematopoietic Chimerism
B. Gonzalez Nolasco¹, M. Wang¹, W. Orent¹, A. Prunevieille¹, K. Pruner¹, J. O¹, J. Paster¹, J. C. Madsen², G. Benichou¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…
2018 American Transplant Congress
The Impact of a Tobacco Prohibition Policy Compared to a Restrictive Policy on Liver Transplant Candidate Outcomes
A. Likhitsup,¹ A. Hassan,¹ J. Mellinger,¹ F. Askari,¹ G. Winder,² P. Sharma,¹ N. Saeed,³ C. Sonnenday,⁴ R. Fontana.¹
¹Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI; ²Department of Psychiatry, University of Michigan, Ann Arbor, MI; ³Department of Internal Medicine, Beaumont Hospital, Dearborn, MI; ⁴Department of Surgery, University of Michigan, Ann Arbor, MI.
Introduction: Substance use disorders (SUD) are common in liver transplant (LT) candidates. Poorer postLT outcomes in tobacco users have led programs to prohibit tobacco use…
2016 American Transplant Congress
Engineering a “Hybrid Thymus” to Promote Transplant Tolerance.
S. AlFadil,¹ M.-J. Kim,² M. Iglesias Lozano,¹ B. Oh,¹ W. Lee,¹ G. Brandacher,¹ T. Serworld,² G. Raimondi.¹
¹Plastic & Recnstructive Surgery, Johns Hopkins Medical Institute, Baltimore, MD; ²Joslin Diabetes Center, Boston, MA.
Purpose: Targeting the process of central (thymic) selection of developing T lymphocytes is the key tolerogenic mechanism of bone marrow transplantation (BM-Tx)-based protocols for transplant…
2015 American Transplant Congress
Dual PI3K-mTOR Inhibition on Human T Cell Activation, Proliferation, and Differentiation: The First Step in the Development of New Immunosuppressants
V. Vilchez,¹ A. Castellanos,¹ D. Butterfield,³ M. Mitov,³ C. Hoopes,¹ F. Marti,² R. Gedaly.¹
¹Department of Surgery - Transplant Section, University of Kentucky, Lexington, KY; ²Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY; ³Free Radical Biology in Cancer Shared Resource Facility, University of Kentucky, Lexington, KY.
Background: Regulatory T lymphocytes (Tregs) contribute to transplant tolerance. We have demonstrated that the inhibition of PI3K-mTOR pathway has a major role in the differentiation…