ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Negative selection"

  • 2020 American Transplant Congress

    Rare Genetic Mutation Triggering Acute Liver Failure in a Toddler Needing a Liver Transplant

    C. B. Chen1, N. Mistry Ambani1, A. Zeft1, R. Garcia-Naviero2, V. Hupertz1, K. Hashimoto1, K. Radhakrishnan1

    1Cleveland Clinic, Cleveland, OH, 2Akron Children's Hospital, Akron, OH

    *Purpose: The AIRE gene plays an important role in immune tolerance by driving negative selection of self-recognizing T-cells. Mutations in this gene are responsible for…
  • 2019 American Transplant Congress

    MHC Cross-Dressing in Mixed Hematopoietic Chimerism

    B. Gonzalez Nolasco1, M. Wang1, W. Orent1, A. Prunevieille1, K. Pruner1, J. O1, J. Paster1, J. C. Madsen2, G. Benichou1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…
  • 2018 American Transplant Congress

    The Impact of a Tobacco Prohibition Policy Compared to a Restrictive Policy on Liver Transplant Candidate Outcomes

    A. Likhitsup,1 A. Hassan,1 J. Mellinger,1 F. Askari,1 G. Winder,2 P. Sharma,1 N. Saeed,3 C. Sonnenday,4 R. Fontana.1

    1Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI; 2Department of Psychiatry, University of Michigan, Ann Arbor, MI; 3Department of Internal Medicine, Beaumont Hospital, Dearborn, MI; 4Department of Surgery, University of Michigan, Ann Arbor, MI.

    Introduction: Substance use disorders (SUD) are common in liver transplant (LT) candidates. Poorer postLT outcomes in tobacco users have led programs to prohibit tobacco use…
  • 2016 American Transplant Congress

    Engineering a “Hybrid Thymus” to Promote Transplant Tolerance.

    S. AlFadil,1 M.-J. Kim,2 M. Iglesias Lozano,1 B. Oh,1 W. Lee,1 G. Brandacher,1 T. Serworld,2 G. Raimondi.1

    1Plastic & Recnstructive Surgery, Johns Hopkins Medical Institute, Baltimore, MD; 2Joslin Diabetes Center, Boston, MA.

    Purpose: Targeting the process of central (thymic) selection of developing T lymphocytes is the key tolerogenic mechanism of bone marrow transplantation (BM-Tx)-based protocols for transplant…
  • 2015 American Transplant Congress

    Dual PI3K-mTOR Inhibition on Human T Cell Activation, Proliferation, and Differentiation: The First Step in the Development of New Immunosuppressants

    V. Vilchez,1 A. Castellanos,1 D. Butterfield,3 M. Mitov,3 C. Hoopes,1 F. Marti,2 R. Gedaly.1

    1Department of Surgery - Transplant Section, University of Kentucky, Lexington, KY; 2Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY; 3Free Radical Biology in Cancer Shared Resource Facility, University of Kentucky, Lexington, KY.

    Background: Regulatory T lymphocytes (Tregs) contribute to transplant tolerance. We have demonstrated that the inhibition of PI3K-mTOR pathway has a major role in the differentiation…

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