2020 American Transplant Congress
Rare Genetic Mutation Triggering Acute Liver Failure in a Toddler Needing a Liver Transplant
1Cleveland Clinic, Cleveland, OH, 2Akron Children's Hospital, Akron, OH
*Purpose: The AIRE gene plays an important role in immune tolerance by driving negative selection of self-recognizing T-cells. Mutations in this gene are responsible for…2019 American Transplant Congress
MHC Cross-Dressing in Mixed Hematopoietic Chimerism
*Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…2018 American Transplant Congress
The Impact of a Tobacco Prohibition Policy Compared to a Restrictive Policy on Liver Transplant Candidate Outcomes
Introduction: Substance use disorders (SUD) are common in liver transplant (LT) candidates. Poorer postLT outcomes in tobacco users have led programs to prohibit tobacco use…2016 American Transplant Congress
Engineering a “Hybrid Thymus” to Promote Transplant Tolerance.
Purpose: Targeting the process of central (thymic) selection of developing T lymphocytes is the key tolerogenic mechanism of bone marrow transplantation (BM-Tx)-based protocols for transplant…2015 American Transplant Congress
Dual PI3K-mTOR Inhibition on Human T Cell Activation, Proliferation, and Differentiation: The First Step in the Development of New Immunosuppressants
Background: Regulatory T lymphocytes (Tregs) contribute to transplant tolerance. We have demonstrated that the inhibition of PI3K-mTOR pathway has a major role in the differentiation…
American Transplant Congress abstracts