Articles tagged "Necrosis"

2018 American Transplant Congress
Linking Donor Ischemia Reperfusion Injury (IRI) to Costimulatory Blockade Resistant Murine Heart Graft Rejection through Complement-Initiated Necroptosis
R. Ang, N. Chun, A. Ting, P. Heeger.
Immunology Institute, Translational Transplant Research, Icahn School of Medicine at Mount Sinai, New York, NY.
We previously showed that prolonged cold ischemic storage (CIS) of donor B6 hearts results in complement dependent, CTLA4Ig-resistant rejection in BALB/c recipients. In this system,…
2018 American Transplant Congress
In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury
I. Linares,¹ A. Bartczak,¹ K. Farrokhi,¹ D. Kollmann,¹ M. Kaths,¹ M. Hamar,¹ P. Urbanellis,¹ S. Ganesh,¹ O. Adeyi,² P. Yip,³ M. Selzner,¹ N. Selzner.¹
¹Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada; ²Department of Pathology, Toronto General Hospital, Toronto, ON, Canada; ³Laboratory of Medicine and Pathobiology, Toronto General Hospital, Toronto, ON, Canada.
Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…
2018 American Transplant Congress
Mitochondrial Membrane Permeability Plays a Critical Role for Endothelial Cell Necroptosis and Cardiac Allograft Rejection
I. Gan, J. Jiang, D. Lian, X. Huang, W. Liu, A. Haig, A. Jevnikar, Z. Zhang.
Matthew Mailing Centre for Translational Transplant Studies, University of Western Ontario, London, ON, Canada; Multi Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; Pathology and Laboratory Medicine, University of Western Ontario, London, ON, Canada; Medicine, University of Western Ontario, London, ON, Canada.
Background: Transplant injury is invariably associated with programmed cell death resulting in delayed graft function and organ rejection. We were the first to describe receptor-interacting…
2018 American Transplant Congress
Assessing Necroptosis in Brain Dead Kidney Donors: Implications for Predicting Recipient Outcomes
A. Zmijewska, J. Murphy, J. Chen, J. Zmijewski, R. Mannon.
Medicine, University of Alabama at Birmingham, Birmingham, AL.
Introduction: Kidney graft transplant obtained from Brain Dead Donors (BDD) is more frequently associated with development of delayed graft function (DGF) and higher risk of…
2017 American Transplant Congress
Necroptotic Cellular Death Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.
R. Ang, P. Heeger, A. Ting.
Immunology Institute, Icahn School of Medicine at Mount Sinai, NYC, NY
While graft injury following cold ischemia reperfusion (IR) can accelerate graft rejection, mechanisms are incompletely understood. Evidence indicates that posttransplant IR injury is associated with…
2017 American Transplant Congress
Prolonged Liver Ischemia Triggers Necrotic Depletion of TIM4+ Kupffer Cells to Facilitate Tissue Inflammatory Immune Activation in Liver Ischemia-Reperfusion Injury.
H. Wang,¹ S. Yue,¹ M. Ni,¹ R. Busittil,¹ J. Kupiec-Weglinski,¹ L. Lu,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA; ²Liver Surgery, The First affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu Province, China
Although mechanisms of immune activation against liver ischemia-reperfusion injury (IRI) have been studied extensively, questions regarding liver resident Kupffer cells vs. infiltrating macrophages (iM[Oslash]s) remain…
2017 American Transplant Congress
PPAR-γ Agonist Attenuates Hepatic Ischemia-Reperfusion Injury in a Mouse Model by Regulating Kupffer Cell Polarization.
I. Linares, K. Farrokhi, J. Echeverri, M. Kaths, D. Kollman, M. Hamar, P. Urbanellis, S. Ganesh, O. Adeyi, P. Yip, N. Selzner, M. Selzner.
Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada
PPAR-γ agonists have shown protective effect on ischemia-reperfusion injury (IRI) in cerebral and renal tissue. The effects of PPAR-γ on hepatic IRI is unclear. We…
2016 American Transplant Congress
Liver Ischemia Induces Kupffer Cell Necroptosis to Facilitate Liver Inflammatory Immune Activation.
S. Yue,¹ H. Zhou,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsAlthough mechanisms of liver immune activation against ischemia reperfusion injury (IRI) have been studied extensively, cellular bases have yet to be fully defined…
2016 American Transplant Congress
Activating Transcription Factor 5 (ATF5) Regulates Liver Ischemia/Reperfusion Injury.
G.-Q. Shen,² M. Morita,¹ J. Fung,² L. Lu,^1,2 S. Qian.^1,2
¹Immunology, LernerResearch Institute, Cleveland Clinic, Cleveland, OH; ²General Surgery, Transplant Center, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Activating transcription factor 5 (ATF5), a member of the ATF/cAMP response element-binding proteins, is extremely highly expressed in the liver, the significance of which is…
2016 American Transplant Congress
Hydrogen Sulfide Treatment Mitigates Donor Tissue Necrosis During Prolonged Cold Storage and Improves Survival Following Allogeneic Renal Transplantation.
I. Lobb,^1,3 W. Liu,² J. Jiang,³ D. Lian,³ A. Sener.^1,3,4
¹Microbiology and Immunology, Western University Canada, London, ON, Canada; ²Pathology, Western University Canada, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴Surgery, Western University Canada, London, ON, Canada.
Organ procurement is inherently associated with ischemia-reperfusion injury (IRI), resulting from loss and subsequent restoration of blood flow, which is detrimental to short- and long-term…