2022 American Transplant Congress
Local Mesenchymal Stem Cell Therapy for the Ex Vivo Preservation of a Porcine Vascularized Composite Allograft with 24-hour Normothermic Machine Perfusion
*Purpose: Given therapeutic limitations in limb salvage, we sought to demonstrate the efficacy of combining local mesenchymal stem cells (MSCs) infusion with fresh whole blood…2022 American Transplant Congress
Hepatocyte SIRT1 Regulation of Apoptosis-Mediated Pyroptosis Cell Death in Mouse and Human Liver Transplantation
1UCLA Medical Center, Los Angeles, CA, 2NIEHS, Durham, NC
*Purpose: Cold static preservation is a gold-standard in orthotopic liver transplantation (OLT). However, the role of hepatocyte-specific SIRT1 transcriptional regulation of cell death programs during…2020 American Transplant Congress
Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers
Surgery, Washington University St. Louis, St. Louis, MO
*Purpose: Aged livers are far more susceptible to ischemia/reperfusion (I/R) injury than young livers. No therapeutic strategies are available to reduce I/R injury in elderly…2020 American Transplant Congress
Cyclophilin-D Inhibition Mitigates Cardiac Allograft Ischemia-Reperfusion Injury and Rejection
*Purpose: The clinical relevance of ischemia-reperfusion injury (IRI) in the context of organ transplantation is well-established. IRI is associated with various forms of programmed cell…2019 American Transplant Congress
Treprostinil Attenuates Renal Ischemia-Reperfusion Injury in Rat
*Purpose: Kidney transplantation (KTx) is the optimal treatment for end-stage renal diseases. The surgical procedure of KTx inherently requires cold ischemic preservation and warm reperfusion…2019 American Transplant Congress
Interferon Sensitivity Promotes Recovery from Acetaminophen Induced Liver Injury
Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: The current study was undertaken to assess the role of inflammatory signaling during induction of and recovery from acetaminophen induced acute liver failure.*Methods: C57BL/6…2019 American Transplant Congress
Prolonged Cold Ischemic Storage Induces Allograft Necro-Inflammation That Increases Graft Susceptibility to T Cell Mediated Rejection
1Icahn School of Medicine at Mount Sinai, New York, NY, 2Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged cold ischemic storage (CIS) of murine cardiac allografts causes complement dependent, CTLA4Ig-resistant rejection that is associated with 48h post-transplant elevations in serum levels…2019 American Transplant Congress
Innate Immunity in Brain Dead Donors: Implications of Necroptosis in Kidney Allograft Outcomes
*Purpose: Regulated necrosis (necroptosis) has been implicated in renal injury from nephrotoxic agents and ischemia. With the use of suboptimal brain dead donors (BDDs) to…2019 American Transplant Congress
Role of RIPK3 in Chronic Rejection Following Human Lung Transplantation
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Immunological mechanisms leading to chronic rejection, bronchiolitis obliterans syndrome (BOS), following human lung transplantation remains unclear though a strong correlation have been identified between…2018 American Transplant Congress
Linking Donor Ischemia Reperfusion Injury (IRI) to Costimulatory Blockade Resistant Murine Heart Graft Rejection through Complement-Initiated Necroptosis
We previously showed that prolonged cold ischemic storage (CIS) of donor B6 hearts results in complement dependent, CTLA4Ig-resistant rejection in BALB/c recipients. In this system,…
American Transplant Congress abstracts