ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Necrosis"

  • 2022 American Transplant Congress

    Hepatocyte SIRT1 Regulation of Apoptosis-Mediated Pyroptosis Cell Death in Mouse and Human Liver Transplantation

    K. Kadono1, H. Hirao1, H. Kojima1, K. J. Dery1, X. Li2, J. Kupiec-Weglinski1

    1UCLA Medical Center, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: Cold static preservation is a gold-standard in orthotopic liver transplantation (OLT). However, the role of hepatocyte-specific SIRT1 transcriptional regulation of cell death programs during…
  • 2022 American Transplant Congress

    Local Mesenchymal Stem Cell Therapy for the Ex Vivo Preservation of a Porcine Vascularized Composite Allograft with 24-hour Normothermic Machine Perfusion

    A. Bernal1, J. Hinshaw1, J. Pena1, C. Hinshaw1, D. Wood1, K. Zimmern2, N. McMahon2, J. Ling2, W. Zhang1, E. Weitzel1

    1US Army Institute of Surgical Research/59th MDW, San Antonio, TX, 2Southwest Research Institute, San Antonio, TX

    *Purpose: Given therapeutic limitations in limb salvage, we sought to demonstrate the efficacy of combining local mesenchymal stem cells (MSCs) infusion with fresh whole blood…
  • 2020 American Transplant Congress

    Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers

    J. Kim, C. Lee, W. Chapman

    Surgery, Washington University St. Louis, St. Louis, MO

    *Purpose: Aged livers are far more susceptible to ischemia/reperfusion (I/R) injury than young livers. No therapeutic strategies are available to reduce I/R injury in elderly…
  • 2020 American Transplant Congress

    Cyclophilin-D Inhibition Mitigates Cardiac Allograft Ischemia-Reperfusion Injury and Rejection

    A. Qamar1, P. McLeod2, J. Jiang2, X. Huang2, A. M. Jevnikar2, Z. Zhang2

    1Pathology & Laboratory Medicine, University of Western Ontario, London, ON, Canada, 2London Health Sciences Center, London, ON, Canada

    *Purpose: The clinical relevance of ischemia-reperfusion injury (IRI) in the context of organ transplantation is well-established. IRI is associated with various forms of programmed cell…
  • 2019 American Transplant Congress

    Treprostinil Attenuates Renal Ischemia-Reperfusion Injury in Rat

    M. Ding1, E. Tolbert2, M. Birkenbach3, C. Chung4, R. Gohh5, F. Akhlaghi1, N. Ghonem1

    1Biomedical and Pharmaceutical Sciences, URI, Kingston, RI, 2Nephrology, Rhode Island Hsopital, Providence, RI, 3Pathology, Rhode Island Hospital, Providence, RI, 4Surgery, Rhode Island Hospital, Providence, RI, 5Organ Transplantation, Rhode Island Hospital, Brown University, KINGSTON, RI

    *Purpose: Kidney transplantation (KTx) is the optimal treatment for end-stage renal diseases. The surgical procedure of KTx inherently requires cold ischemic preservation and warm reperfusion…
  • 2019 American Transplant Congress

    Interferon Sensitivity Promotes Recovery from Acetaminophen Induced Liver Injury

    S. Datta, T. Hamilton, G. C. Sen

    Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, OH

    *Purpose: The current study was undertaken to assess the role of inflammatory signaling during induction of and recovery from acetaminophen induced acute liver failure.*Methods: C57BL/6…
  • 2019 American Transplant Congress

    Prolonged Cold Ischemic Storage Induces Allograft Necro-Inflammation That Increases Graft Susceptibility to T Cell Mediated Rejection

    N. Chun1, R. Ang1, J. Horwitz1, R. Fairchild2, W. Baldwin III2, A. Ting1, P. S. Heeger1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2Cleveland Clinic, Cleveland, OH

    *Purpose: Prolonged cold ischemic storage (CIS) of murine cardiac allografts causes complement dependent, CTLA4Ig-resistant rejection that is associated with 48h post-transplant elevations in serum levels…
  • 2019 American Transplant Congress

    Innate Immunity in Brain Dead Donors: Implications of Necroptosis in Kidney Allograft Outcomes

    A. Ang1, A. Zmijewska2, T. M. Stevens3, J. Murphy1, R. B. Mannon2

    1School of Medicine, UAB, Birmingham, AL, 2Medicine/Nephrology, UAB, Birmingham, AL, 3Pathology, UAB, Birmingham, AL

    *Purpose: Regulated necrosis (necroptosis) has been implicated in renal injury from nephrotoxic agents and ischemia. With the use of suboptimal brain dead donors (BDDs) to…
  • 2019 American Transplant Congress

    Role of RIPK3 in Chronic Rejection Following Human Lung Transplantation

    S. Angara, R. Ravichandran, H. Sodawalla, M. Smith, R. Bremner, T. Mohanakumar

    Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Immunological mechanisms leading to chronic rejection, bronchiolitis obliterans syndrome (BOS), following human lung transplantation remains unclear though a strong correlation have been identified between…
  • 2018 American Transplant Congress

    Donor Deficiency of RIP3 Phosphokinase Activity Shortens Cardiac Allograft Survival in the Setting of Costimulation Blockade

    M. Zhu, K. Samy, L. Lin, J. Wang, L. Cendales, A. Kirk, A. Barbas, T. Brennan.

    Surgery, Duke University, Durham, NC.

    Receptor-interacting protein kinase 3 (RIP3) is critical for necroptosis in the setting of inflammation. It has been shown that kidney and heart allografts deficient in…
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