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Articles tagged "Natural killer cells"

  • 2016 American Transplant Congress

    Natural Killer Cells Display Functional and Receptor Diversity in Response to Alloantigen.

    O. Hatton,1 T. Shawler,1 C. Blish,2 O. Martinez,1 S. Krams.1

    1Division of Abdominal Transplantation, Dept. of Surgery, Stanford University, Stanford; 2Dept of Medicine, Stanford University, Stanford.

    Natural killer (NK) cells play an important role in the first-line defense against tumor and virus-infected cells. Although “missing-self” suggests NK cells would target foreign…
  • 2016 American Transplant Congress

    Clinical and Immunologic Assessments of Immune Responses in a Liver Transplant Patient with CD40L Deficiency and Hyper IgM Syndrome.

    M. Tseng,1 S. Ge,1 R. Roberts,2 C. Kuo,2 J. Choi,1 N. Nissen,1 M. Chu,1 I. Kim,1 B. Shin,1 M. Toyoda,1 S. Jordan.1

    1Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; 2Pediatrics & Immunology, UCLA, Los Angeles, CA.

    Introduction: Monoclonal antibodies that disrupt CD40/CD40 ligand (CD40L) interactions are likely to have utility in human transplantation. However, the extent of the immunosuppressive effects of…
  • 2015 American Transplant Congress

    Mesenchymal Stem Cells Suppress Cytotoxicity of Activated Natural Killer Cells in Liver Via the TRAIL-TRAIL Receptor Pathway in Islet Transplantation

    N. Ishida, K. Ishiyama, F. Hirata, Y. Saeki, Y. Tanaka, H. Ohdan.

    Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    Introduction: Innate immune reactions against islet grafts are considered a major obstacle for intraportal islet transplantation. We have previously reported that liver natural killer (NK)…
  • 2015 American Transplant Congress

    Adoptive Immunotherapy Using Activated NK Cells Ameliorates the FcγRIIIa Gene Polymorphism-Associated Susceptibility to Post Transplant Bloodstream Infection

    S. Shimizu, Y. Tanaka, H. Tazawa, S. Verma, H. Ohdan.

    Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    Background: At ATC 2014, we demonstrated that detection of single nucleotide polymorphisms (SNP) of FcγRIIIa helps predict the susceptibility of liver transplant (LT) recipients to…
  • 2015 American Transplant Congress

    Host NK Cell Allorecognition of Passenger Donor Lymphocytes Within Allografts Is Essential for Preventing Augmentation of Recipient Adaptive Alloimmunity

    J. Ali, I. Harper, M. Negus, E. Bolton, K. Saeb-Parsy, J. Bradley, G. Pettigrew.

    Department of Surgery, University of Cambridge, Cambridge, United Kingdom.

    Background:Memory T cells are now appreciated to reside in peripheral non-lymphoid tissue, but how their presence within solid organ allografts impacts upon transplant outcomes is…
  • 2015 American Transplant Congress

    Detection of Donor-Specific Anti-HLA Antibodies Is Associated With Changes in the Peripheral Distribution of NK Cell Subsets in Kidney Allograft Recipients

    M. Crespo,1 D. Redondo,1 J. Yelamos,2 A. Muntasell,2 M. Pérez-Sáez,1 M. Lopez-Montañes,3 C. Garcia,4 A. Torío,5 J. Hernandez,4 M. Mir,1 M. Lopez-Botet,3 J. Pascual.1

    1Nephrology, Hospital del Mar, Barcelona, Spain; 2Servicio de Inmunología, Institut Mar d'Investigacions Mediques, Barcelona, Spain; 3Grup de Investigacio en Immunologia, Universitat Pompeu Fabra, Barcelona, Spain; 4Laboratori de Referencia de Catalunya, Barcelona, Spain; 5Immunology Unit, Hospital de Alicante, Alicante, Spain.

    Background: Microvascular damage has become the real protagonist involved in antibody-mediated rejection and NK-cell antibody-dependent cell mediated cytotoxicity (ADCC) has been proposed as a contributing…
  • 2015 American Transplant Congress

    Evaluation of Natural Killer Cell Activation by NK Cell-Specific Interferon-Gamma-Releasing Assay

    J. Ryu,1 K. Park,1 Y. Kim,2 E.-J. Oh.2

    1Department of Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea; 2Laboratory Medicine, Seoul St. Mary's Hospital, the Catholic University of Korea, Seoul, Republic of Korea.

    Introduction: Although NK cell activity (NKA) has a variety of measuring markers including chromiun release assay and flowcytometry-based cytolysis, limitations such as radioactivity and lack…
  • 2015 American Transplant Congress

    Allo-Stimulated Interferon-γ Release and Natural Killer Cell Function Defines and Risk Stratifies Cancer Development in Kidney Transplant Recipients Who Have Cancer Post-transplantation

    C. Hope,1,2 A. Fuss,1,2 W. Hanf,1 P. Coates,1,2 P. Heeger,3 R. Carroll.1,2

    1The Centre for Clinical and Experimental Transplantation (CCET), Central Northern Adelaide Renal and Transplantation Services (CNARTS), Adelaide, South Australia, Australia; 2Medicine, The University of Adelaide, Adelaide, South Australia, Australia; 3Icahn School of Medicine, The Recanati-Miller Transplant Institute, New York City, NY.

    Reducing immunosuppression is efficacious in primary prevention of cancer in Kidney Transplant Recipients (KTR) but can precipitate graft rejection. Conventional immunosuppressive drug monitoring fails to…
  • 2015 American Transplant Congress

    Significant Reduction in TRAIL-Expressing NK Cells in Remnant Liver After Partial Hepatectomy Is Strongly Associated With the Impaired Intrahepatic CXCL9–CXCR3 Pathway

    T. Yano, M. Ohira, H. Ohdan.

    Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima City, Japan.

    Antitumor activity of liver natural killer (NK) cells decreases after partial hepatectomy or liver transplantation (LT), suggesting the susceptibility of patients with depressed immune status…
  • 2015 American Transplant Congress

    CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment

    R. Hotta,1 M. Ohira,2 T. Matsuura,1 I. Muraoka,1 P. Tryphonopoulos,1 J. Fan,1 A. Tekin,1 H. Ohdan,2 A. Tzakis,3 R. Vianna,1 S. Nishida.1

    1University of Miami, Miami, FL; 2Hiroshima University, Hiroshima, Japan; 3Cleveland Clinic Florida, Weston, FL.

    Background: T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface…
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