Articles tagged "Natural killer cells"

2016 American Transplant Congress
NK-Activating MCMV Strain Is Associated with Increased Murine Renal Transplant Injury.
M. Shimamura,¹ M. Li,² B. Chen,² J. George,² T. Schoeb.³
¹Vaccines and Immunity, Pediatric Infectious Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, OH; ²Pediatric Infectious Diseases, Cardiothoracic Surgery, Nephrology, University of Alabama at Birmingham, Birmingham, AL; ³Pathology and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Background: CMV contributes to inferior longterm kidney transplant survival. In a murine model, NK cells infiltrate MCMV infected renal allografts in greater numbers than in…
2016 American Transplant Congress
Combination of Veto Cell Transfer and iNKT Cell Therapy Establishes Complete Hematopoietic Chimerism in Non-Myeloablative BMT Recipients.
R. Ishii,¹ T. Hirai,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Laboratory for Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Hematopoietic chimerism after non-myeloablative bone marrow transplantation (nmBMT) has been found beneficial for establishment of transplant tolerance. Since bone marrow cells (BMCs) are endowed with…
2015 American Transplant Congress
NKp46 Clusters at the NK Cell Immune Synapse Regulate Specific Effector Functions
U. Hadad,^1,2 T. Thauland,¹ M. Butte,¹ A. Porgador,² O. Martinez,¹ S. Krams.¹
¹Stanford University, Stanford, CA; ²Ben Gurion University of the Negev, Beer Sheva, Israel.
Natural Killer (NK) cells play an important role in the first-line defense against tumor and virus-infected cells. Studies suggest NK cells have a dichotomous role…
2015 American Transplant Congress
The Influence of Immunosuppressive Drugs On the Epithelial Microenvironment in Solid Organ Transplantation – Identification of Biomarker Candidates for Rejection Vs. Tolerance
A. Akhdar,¹ B. Mueller,² C. Neudoerfl,¹ F. Lehner,³ M. Stevanovic-Meyer,¹ K. Daemen,¹ J. Keil,¹ H. Haller,⁴ C. Blume,^4,5 C. Falk.^1,6
¹Institute of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²MorphoSys, Munich, Germany; ³Department of General, Visceral and Transplantation Surgery, Hanover Medical School, Hanover, Germany; ⁴Department of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; ⁵Institute of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; ⁶German Center for Infection Research, Braunschweig, Germany.
In the context of kidney transplantation, NK cells may play an important role by targeting the allogeneic organ due to "missing-self recognition", which leads to…
2015 American Transplant Congress
Adoptive Immunotherapy With Liver Allograft-Derived NK Cells Improves Recurrence-Free Survival After Living-Donor Liver Transplantation in Patients With Hepatocellular Carcinoma
N. Tanimine, Y. Tanaka, K. Ishiyama, M. Ohira, S. Shimizu, T. Yano, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Introduction: Previous studies revealed that the recurrence rate of hepatocellular carcinoma (HCC) was still 10–20%, even among liver transplantation (LT) recipients meeting the Milan criteria…
2015 American Transplant Congress
NK Cells of Kidney Transplant Recipients Show a Reduced Capacity to Produce Cytokines But Retain Their Cytotoxic Capacity
U. Hoffmann,¹ C. Neudoerfl,¹ K. Daemen,¹ J. Keil,¹ C. Blume,^2,3 F. Lehner,⁴ H. Haller,² C. Falk.^1,5
¹Inst. of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²Dept. of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; ³Inst. of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; ⁴Dept. of General, Visceral, and Transplantation Surgery, Hanover Medical School, Hanover, Germany; ⁵German Center for Infection Research, Braunschweig, Germany.
The role of NK cells in either graft rejection or tolerance induction is still discussed controversially. In order to clarify the effect of long-term immunosuppression…
2015 American Transplant Congress
Analysis of In-Vitro Effects of Immunosuppression on NK Cell Subsets in the Presence of Cytomegalovirus
S. Keshwani, D. Kumar, S. Han, S. Husain, V. Ferreira, P. Ashton, A. Humar.
UHN, Toronto, Canada.
Background: NK cells may play an important role in the control of CMV replication post-transplant. NK cells can be divided into subsets based on surface…
2015 American Transplant Congress
IL-2-Dependent Natural Killer Cell Responses to Epstein-Barr Virus B Cell Lymphomas Involve the NKG2A/NKG2C Axis
O. Hatton, D. Strauss-Albee, C. Blish, C. Esquivel, S. Krams, O. Martines.
Stanford University School of Medicine, Stanford, CA.
Epstein Barr virus (EBV) infection elicits a strong host immune response that is considered to be essential for control of the virus and for preventing…
2015 American Transplant Congress
CD27^low NK Cells Prolong Allograft Survival in Mice By Inhibiting CD8⁺ T Cell Responses Through Controlling Graft-Derived Donor DCs
A. Kroemer,^1,2 M. Lantow,¹ E. Eggenhofer,¹ M. Sabet-Baktach,¹ P. Renner,¹ H. Schlitt,¹ E. Geissler.¹
¹Department of Surgery, University Hospital Regensburg, Regensburg, Germany; ²Georgetown Transplant Institute, Washington, DC.
The underlying mechanisms by which distinct NK cell subsets promote either allograft rejection or survival remain unclear. Here, we tested the hypothesis that distinctively mature…
2015 American Transplant Congress
Recipient Immunity to Murine Cytomegalovirus Influences Natural Killer Cell Responses in Infected Renal Allografts
M. Shimamura,¹ M. Li,¹ B. Chen,² J. George.²
¹Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL; ²Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham.
BACKGROUND: Human cytomegalovirus (CMV) is associated epidemiologically with renal allograft loss, but the impact of recipient CMV immunity upon graft survival is unclear. Natural killer…