2016 American Transplant Congress
Mass Cytometry Reveals NK Cell and T Cell Subsets in Pediatric Liver Transplant Patients with Acute Rejection.
1Pediatrics, Stanford/LPCH, Palo Alto, CA; 2Surgery, Stanford, Palo Alto, CA.
Proper evaluation of the immune status of liver transplant recipients is crucial for appropriate post-transplant management. Current monitoring of graft function relies mainly on non-specific…2016 American Transplant Congress
Natural Killer CD16/FcR Profiles May Associate with Enhanced Humoral Responsiveness in Heart Transplant Recipients with Cardiac Allograft Vasculopathy.
Natural Killer cells (NK) are immune effectors of antibody-dependent cellular cytotoxicity (ADCC). Their role in mediating adverse effects of Donor-specific anti-HLA antibodies (DSA) towards cardiac…2016 American Transplant Congress
Impact of Mixed Xenogeneic Porcine Hematopoietic Chimerism on Human NK Cell Recognition in a Humanized Mouse Model.
Xenotransplantation is a potential solution for the shortage of organs for transplantation. However, potent xenograft rejection responses present a formidable barrier. Mixed xenogeneic hematopoietic chimerism…2016 American Transplant Congress
Innate Lymphoid Cells Play a Key Role in Controlling Antimicrobial Defense in Intestinal Transplant Recipients.
MedStar Georgetown Transplant Institute, Washington DC.
A. Infectious complications are the leading cause of death early after intestinal transplantation (ITx). Etiologies underlying this remain unclear. Innate lymphoid cells (ILCs) have very…2016 American Transplant Congress
NK Cells Play a Critical Role in Mediating Inflammation and Graft Failure During Antibody-Mediated Rejection of Kidney Allografts.
While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…2016 American Transplant Congress
NK-Activating MCMV Strain Is Associated with Increased Murine Renal Transplant Injury.
Background: CMV contributes to inferior longterm kidney transplant survival. In a murine model, NK cells infiltrate MCMV infected renal allografts in greater numbers than in…2016 American Transplant Congress
Combination of Veto Cell Transfer and iNKT Cell Therapy Establishes Complete Hematopoietic Chimerism in Non-Myeloablative BMT Recipients.
Hematopoietic chimerism after non-myeloablative bone marrow transplantation (nmBMT) has been found beneficial for establishment of transplant tolerance. Since bone marrow cells (BMCs) are endowed with…2016 American Transplant Congress
Gene Expression Microarray Analysis of Purified CD16-Stimulated Human NK Cells and Indication Biopsies Supports a CD16-Mediated Role for NK Cells in Antibody-Mediated Kidney Rejection.
BACKGROUND: CD16α mediates NK cell responses to donor-specific IgG antibodies (DSA), and shares mechanisms with effector T cell receptor (TCR) stimulation. Whether CD16α-inducible transcripts are…2016 American Transplant Congress
Enhanced Natural Killer Responsiveness Is a Potent Cytotoxic Mechanism Associating to Kidney Allograft Dysfunction and Pathogenic Effects of Donor-Specific Antibodies (DSA).
While antibody mediated rejection (ABMR) is a major cause of kidney transplant loss, the role of Natural Killer cells (NK) as immune effectors of complement-independent…2016 American Transplant Congress
NKG2A-Expressing Natural Killer Cells Dominate the Response to Latent Epstein-Barr Virus Infection.
Introduction: EBV infection elicits a robust host immune response in healthy, immunocompetant individuals. EBV immunity is essential for preventing EBV-associated lymphomas in transplant recipients, including…
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