Articles tagged "Natural killer cells"

2016 American Transplant Congress
NK Cells Play a Critical Role in Mediating Inflammation and Graft Failure During Antibody-Mediated Rejection of Kidney Allografts.
T. Tanaka,^1,2 N. Kohei,¹ N. Dvorina,¹ A. Valujskikh,¹ W. Baldwin 3rd,¹ R. Fairchild.¹
¹Department of Immunology, Cleveland Clinic, Cleveland, OH; ²Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…
2016 American Transplant Congress
NK-Activating MCMV Strain Is Associated with Increased Murine Renal Transplant Injury.
M. Shimamura,¹ M. Li,² B. Chen,² J. George,² T. Schoeb.³
¹Vaccines and Immunity, Pediatric Infectious Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, OH; ²Pediatric Infectious Diseases, Cardiothoracic Surgery, Nephrology, University of Alabama at Birmingham, Birmingham, AL; ³Pathology and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Background: CMV contributes to inferior longterm kidney transplant survival. In a murine model, NK cells infiltrate MCMV infected renal allografts in greater numbers than in…
2016 American Transplant Congress
Combination of Veto Cell Transfer and iNKT Cell Therapy Establishes Complete Hematopoietic Chimerism in Non-Myeloablative BMT Recipients.
R. Ishii,¹ T. Hirai,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Laboratory for Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Hematopoietic chimerism after non-myeloablative bone marrow transplantation (nmBMT) has been found beneficial for establishment of transplant tolerance. Since bone marrow cells (BMCs) are endowed with…
2016 American Transplant Congress
Gene Expression Microarray Analysis of Purified CD16-Stimulated Human NK Cells and Indication Biopsies Supports a CD16-Mediated Role for NK Cells in Antibody-Mediated Kidney Rejection.
M. Parkes,¹ P. Halloran,¹ L. Hidalgo.²
¹Dept. of Medicine, University of Alberta, Edmonton, AB, Canada; ²Dept. of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND: CD16α mediates NK cell responses to donor-specific IgG antibodies (DSA), and shares mechanisms with effector T cell receptor (TCR) stimulation. Whether CD16α-inducible transcripts are…
2016 American Transplant Congress
Enhanced Natural Killer Responsiveness Is a Potent Cytotoxic Mechanism Associating to Kidney Allograft Dysfunction and Pathogenic Effects of Donor-Specific Antibodies (DSA).
P. Paul,^1,2 T. Legris,³ C. Picard,⁴ D. Todorova,^1,2 L. Lyonnet,¹ L. Daniel,⁵ B. Dussol,^3,6 V. Moal,³ H. Vacher Coponat,³ Y. Berland,³ F. Dignat-George,^1,2 S. Burtey.^2,3
¹Hematology, Assistance Publique Hopitaux Marseille, Marseille, France; ²UMR-1076, VRCM, Aix Marseille University, INSERM, Marseille, France; ³Nephrology Dialysis Renal Transplantation Center, Assistance Publique Hopitaux Marseille, Marseille, France; ⁴Immunogenetics, Etablissement Français du Sang, Marseille, France; ⁵Anatomy, Pathology, Neuropathology, Assistance Publique Hopitaux Marseille, Marseille, France; ⁶Center for Clinical Investigation, Assistance Publique Hopitaux Marseille, Marseille, France.
While antibody mediated rejection (ABMR) is a major cause of kidney transplant loss, the role of Natural Killer cells (NK) as immune effectors of complement-independent…
2016 American Transplant Congress
NKG2A-Expressing Natural Killer Cells Dominate the Response to Latent Epstein-Barr Virus Infection.
O. Hatton,¹ D. Strauss-Albee,² S. Krams,¹ C. Blish,² O. Martinez.¹
¹Surgery, Stanford University School of Medicine, Stanford, CA; ²Medicine, Stanford Univerity School of Medicine, Stanford, CA.
Introduction: EBV infection elicits a robust host immune response in healthy, immunocompetant individuals. EBV immunity is essential for preventing EBV-associated lymphomas in transplant recipients, including…
2016 American Transplant Congress
Natural Killer Cells Display Functional and Receptor Diversity in Response to Alloantigen.
O. Hatton,¹ T. Shawler,¹ C. Blish,² O. Martinez,¹ S. Krams.¹
¹Division of Abdominal Transplantation, Dept. of Surgery, Stanford University, Stanford; ²Dept of Medicine, Stanford University, Stanford.
Natural killer (NK) cells play an important role in the first-line defense against tumor and virus-infected cells. Although “missing-self” suggests NK cells would target foreign…
2016 American Transplant Congress
Clinical and Immunologic Assessments of Immune Responses in a Liver Transplant Patient with CD40L Deficiency and Hyper IgM Syndrome.
M. Tseng,¹ S. Ge,¹ R. Roberts,² C. Kuo,² J. Choi,¹ N. Nissen,¹ M. Chu,¹ I. Kim,¹ B. Shin,¹ M. Toyoda,¹ S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pediatrics & Immunology, UCLA, Los Angeles, CA.
Introduction: Monoclonal antibodies that disrupt CD40/CD40 ligand (CD40L) interactions are likely to have utility in human transplantation. However, the extent of the immunosuppressive effects of…
2016 American Transplant Congress
Mass Cytometry Reveals NK Cell and T Cell Subsets in Pediatric Liver Transplant Patients with Acute Rejection.
A. Lau,^1,2 K. Haas,¹ T. Shawler,² C. Esquivel,² O. Martinez,² R. Castillo,¹ S. Krams.²
¹Pediatrics, Stanford/LPCH, Palo Alto, CA; ²Surgery, Stanford, Palo Alto, CA.
Proper evaluation of the immune status of liver transplant recipients is crucial for appropriate post-transplant management. Current monitoring of graft function relies mainly on non-specific…
2016 American Transplant Congress
Natural Killer CD16/FcR Profiles May Associate with Enhanced Humoral Responsiveness in Heart Transplant Recipients with Cardiac Allograft Vasculopathy.
P. Paul,^1,2 C. Picard,^3,4 E. Sampol,⁵ L. Lyonnet,¹ J. Di Cristofaro,^3,4 G. Lano,^6, B. Dussol,^6, F. Collart,⁷ F. Sabatier,^1,2 F. Dignat George,^1,2 A. Mouly Bandini.⁷
¹Hematology, Assistance Publique-Hopitaux Marseille (AP-HM), Marseille, France; ²UMR-1076, Aix Marseille Université (AMU), INSERM, Marseille, France; ³Établissement Français du Sang, Marseille, France; ⁴UMR7268, AMU, CNRS, Marseille, France; ⁵Pharmacokinetics, AP-HM, Marseille, France; ⁶Center for Clinical Investigation, AP-HM, Marseille, France; ⁷Cardiac Surgery, AP-HM, Marseille, France.
Natural Killer cells (NK) are immune effectors of antibody-dependent cellular cytotoxicity (ADCC). Their role in mediating adverse effects of Donor-specific anti-HLA antibodies (DSA) towards cardiac…