2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-CMV IgG, Resulting in Inhibition of Antibody (Ab)-Mediated NK Cell Activation in Kidney Transplant Patients (KTX Pts).
Background: Viral infections represent significant morbidity factors for KTx Pts. Ab-dependent cell-mediated cytotoxicity (ADCC) is a major pathway to eliminate virally infected cells and is…2017 American Transplant Congress
NKG2C+ NK Cell Adaptive Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.
Cytomegalovirus (CMV) infection in kidney transplant recipients (KTR) has been associated with an increased risk of graft loss and reduced host survival. CMV promotes persistent…2017 American Transplant Congress
Sequential Monitoring of Natural Killer Cell Reconstitution Against CMV Reactivation After Allogeneic Hematopoietic Stem Cell Transplantation.
Cytomegalovirus (CMV) reactivation has an impact on significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Natural killer (NK) cells are the first…2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-HLA Antibody (Ab), Resulting in Inhibition of Anti-HLA Ab-Mediated NK Cell Activation and Ab-Dependent Cell-Mediated Cytotoxicity (ADCC) in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts).
Background: Ab-mediated rejection (ABMR) is a major obstacle in HS KTx Pts. ADCC is a mechanism responsible for ABMR. IdeS cleaves all 4 human IgG…2017 American Transplant Congress
NK Cells Respond to CMV Lysate by Inducing IFNγ and CD107a Surface Expression in an Antibody-Dependent Manner: This Represents a Cytokine Flow Cytometry (CFC) Assay That Could Assess Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) as a Marker of CMV Immunity in Transplant Recipients.
Background: Viral infections represent significant morbidity factors for transplant recipients. Tools to assess the efficacy of viral-specific responses are lacking. ADCC is the major antibody-mediated…2017 American Transplant Congress
CD40/CD40 Ligand Signal Controls Cytotoxic Ability of Natural Killer Cells After Invariant Natural Killer T Cell Stimulation.
Because iNKT cells have powerful immune-regulatory function, an administration of iNKT cell ligand; α-galactosylceramide (aGC) is one of the potent strategies for induction of transplant…2017 American Transplant Congress
The Beneficial Effects of mTOR Inhibitors on Liver Resident Natural Killer Cells.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
(Background) The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…2017 American Transplant Congress
CCR5-Mediated Recruitment of NK Cells to the Kidney Is Critical for Resistance to Candida albicans Infections.
We previously showed that CCR5 mediates recruitment of NK cells to the kidney after renal ischemia and reperfusion, which in turn induce the production of…2017 American Transplant Congress
Operational Tolerance in Intestinal Transplantation: A Proven Possibility.
A The purpose of this study is to immunologically characterize the first operationally tolerant intestinal transplant (ITx) patient known to date.B Flow cytometry and rtPCR…2017 American Transplant Congress
Innate Lymphoid Cells Play a Critical Role in Regulating Allograft Homeostasis in Human Intestinal Transplantation.
Transplant, MedStar Georgetown Transplant Institute, Washington, DC
A. The role of recently discovered innate lymphoid cells (ILCs) in intestinal transplant (ITx) patients is poorly understood. Here, we postulate that intestinal ILC subsets…
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