2018 American Transplant Congress
Donor-Specific Antibody Mediates Chronic, but Not Acute, Kidney Allograft Rejection in the Absence of Natural Killer Cells
Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
The incidence of antibody-mediated kidney graft rejection continues to increase. We previously reported that dysregulated donor-specific antibody (DSA) responses were induced in B6.CCR5-/- mice transplanted…2018 American Transplant Congress
Peptides Encoded by EBV Latent Cycle Proteins Affect NK Cell Reactivity
Department of Surgery, Stanford University School of Medicine, Stanford, CA.
Introduction: Epstein–Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…2018 American Transplant Congress
NK Cells with a Lung-Resident Phenotype Represent the Most Prominent Donor Passenger Leukocyte Subset after Clinical Lung Transplantation
ObjectivesDonor passenger leukocytes in peripheral blood of recipients after lung transplantation have been described long time ago. However, kinetics, distribution of T vs. NK cells,…2018 American Transplant Congress
The Role of NKT Cell /IL-17 Axis in the Autoimmune Lupus Nephritis
CD1d-restrictive NKT cells may modulate various chronic autoimmunity through secreting multiple cytokines, but the functional relationships between the different subpopulation still are poorly understood. The…2017 American Transplant Congress
Adoptive Immunotherapy with Liver Allograft-Derived Lymphocytes Compensate for the Susceptibility to Post-Liver Transplant Blood Stream Infection Associated with FCGR3A SNP.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
By studying the single nucleotide polymorphisms (SNPs) of FCGR2A and FCGR3A, genes encoding FcγR, we previously demonstrated the significantly higher incidence of blood stream infections…2017 American Transplant Congress
IVIg+Rituximab Desensitization (DES) Combined with Alemtuzumab (ATZ) Induction Does Not Increase Risk for Viral Infections (VIs) and Associated Complications in HLA-Sensitized (HS) Kidney Transplant Patients (KTx Pts).
Background: VIs represent significant morbidity factors in KTx pts. DES followed by KTx with ATZ induction increased successful Tx rates in HS pts, but may…2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-CMV IgG, Resulting in Inhibition of Antibody (Ab)-Mediated NK Cell Activation in Kidney Transplant Patients (KTX Pts).
Background: Viral infections represent significant morbidity factors for KTx Pts. Ab-dependent cell-mediated cytotoxicity (ADCC) is a major pathway to eliminate virally infected cells and is…2017 American Transplant Congress
NKG2C+ NK Cell Adaptive Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.
Cytomegalovirus (CMV) infection in kidney transplant recipients (KTR) has been associated with an increased risk of graft loss and reduced host survival. CMV promotes persistent…2017 American Transplant Congress
Sequential Monitoring of Natural Killer Cell Reconstitution Against CMV Reactivation After Allogeneic Hematopoietic Stem Cell Transplantation.
Cytomegalovirus (CMV) reactivation has an impact on significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Natural killer (NK) cells are the first…2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-HLA Antibody (Ab), Resulting in Inhibition of Anti-HLA Ab-Mediated NK Cell Activation and Ab-Dependent Cell-Mediated Cytotoxicity (ADCC) in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts).
Background: Ab-mediated rejection (ABMR) is a major obstacle in HS KTx Pts. ADCC is a mechanism responsible for ABMR. IdeS cleaves all 4 human IgG…
- « Previous Page
- 1
- …
- 4
- 5
- 6
- 7
- 8
- …
- 11
- Next Page »