Articles tagged "Natural killer cells"

2018 American Transplant Congress
NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence
M. Terada,¹ J. Duong Van Huyen,² F. Drieux,⁴ C. Legendre,³ P. Bruneval,¹ M. Rabant.²
¹Pathology Department, Georges Pompidou European Hospital, Paris, France; ²Pathology Department, Necker-Enfants Malades Hospital, Paris, France; ³Kidney Transplantation Department, Necker-Enfants Malades Hospital, Paris, France; ⁴Pathology Department, Centre Henri Becquerel, Rouen, France.
Introduction: Among the complex cellular interplay engaged in renal rejection, recent transcriptomic analysis of renal biopsies has detected NK cell transcripts in the setting of…
2018 American Transplant Congress
An In Vitro Model of Human Antibody-Mediated Rejection Depicts Key Role for NK Cells
L. Hidalgo,¹ M. Racape,² A. Loupy,² C. Lefaucheur.²
¹Lab. Med. and Pathology, University of Alberta, Edmonton, AB, Canada; ²Paris Cardiovascular Research Center INSERM, Paris, France.
AIM: Antibody-mediated rejection (ABMR) is the leading cause of kidney allograft loss but its immune mechanisms are incompletely understood. We sought to examine key interactions…
2018 American Transplant Congress
NKG2C+CD57+ NK (G2C+57+) Cells Expanded by CMV Infection Are Highly Responsive to Allo-Antibody (Ab)-Mediated NK Cell Stimulation
B. Shin,¹ D. Puliyanda,² H. Pizzo,² S. Jordan,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Active CMV infection is known to be associated with risk for ABMR in allograft recipients. Ab-dependent cellular cytotoxicity (ADCC) primarily mediated by NK cells…
2018 American Transplant Congress
Regulation of NK Cell Cytotoxicity by TEC Expression of Clr Proteins in Kidney Ischemia Reperfusion Injury (IRI)
B. Fuhrmann,^1,5 D. Lian,⁵ Z. Yin,⁵ S. Ma,^4,5 J. Arp,⁵ Z. Zhang,^2,3,4,5 A. Jevnikar.^1,3,4,5
¹Microbiology and Immunology, Western University, London, Canada; ²Pathology, Western University, London, Canada; ³Medicine, Western University, London, Canada; ⁴Multi-Organ Transplant Program, London Health Sciences Centre, London, Canada; ⁵Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.
Background: Kidney tubular epithelial cells (TEC) may negatively regulate NK cell activation and cytotoxic capacity by surface expression of a novel class of C-type lectin-related…
2017 American Transplant Congress
Sequential Monitoring of Natural Killer Cell Reconstitution Against CMV Reactivation After Allogeneic Hematopoietic Stem Cell Transplantation.
P. Ki Hyun,¹ L. Hyeyoung,² R. Ji Hyeong,¹ K. Yonggoo,² H. Kyungja,² C. Byung Sik,² K. Hee-Je,³ M. Woosung,³ O. Eun-Jee.²
¹Department of Biomedical Science, Graduate School, the Catholic University of Korea, Seoul, Korea; ²Department of Laboratory Medicine, the Catholic University of Korea, Seoul, Korea; ³Department of Internal Medicine, the Catholic University of Korea, Seoul, Korea
Cytomegalovirus (CMV) reactivation has an impact on significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Natural killer (NK) cells are the first…
2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-HLA Antibody (Ab), Resulting in Inhibition of Anti-HLA Ab-Mediated NK Cell Activation and Ab-Dependent Cell-Mediated Cytotoxicity (ADCC) in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts).
S. Ge, M. Chu, J. Choi, S. Louie, A. Kang, A. Vo, A. Peng, S. Jordan, M. Toyoda.
Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Background: Ab-mediated rejection (ABMR) is a major obstacle in HS KTx Pts. ADCC is a mechanism responsible for ABMR. IdeS cleaves all 4 human IgG…
2017 American Transplant Congress
NK Cells Respond to CMV Lysate by Inducing IFNγ and CD107a Surface Expression in an Antibody-Dependent Manner: This Represents a Cytokine Flow Cytometry (CFC) Assay That Could Assess Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) as a Marker of CMV Immunity in Transplant Recipients.
S. Ge, C. Maggie, B.-H. Shin, A. Karasyov, S. Jordan, M. Toyoda.
Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Background: Viral infections represent significant morbidity factors for transplant recipients. Tools to assess the efficacy of viral-specific responses are lacking. ADCC is the major antibody-mediated…
2017 American Transplant Congress
CD40/CD40 Ligand Signal Controls Cytotoxic Ability of Natural Killer Cells After Invariant Natural Killer T Cell Stimulation.
H. Fukuda,¹ T. Hiai,¹ R. Ishii,¹ H. Katsumata,¹ T. Kanzawa,¹ S. Miyairi,¹ M. Ikemiyagi,¹ Y. Ishii,² M. Okumi,¹ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cluster for Industry Partnerships (CIP), RIKEN IMS-RCAI, Tokyo, Japan
Because iNKT cells have powerful immune-regulatory function, an administration of iNKT cell ligand; α-galactosylceramide (aGC) is one of the potent strategies for induction of transplant…
2017 American Transplant Congress
The Beneficial Effects of mTOR Inhibitors on Liver Resident Natural Killer Cells.
J. Saparbay, Y. Tanaka, T. Yano, H. Ohdan.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
(Background) The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…
2017 American Transplant Congress
CCR5-Mediated Recruitment of NK Cells to the Kidney Is Critical for Resistance to Candida albicans Infections.
J. Lee,^1,4 V. Tran,³ H. Kim,¹ B. Kwon,^1,3 K. Park,^1,4 H. Cho.^1,2
¹Biomedical Research Center, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ²Department of Surgery, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, South Korea, Republic of Korea; ³School of Biological Sciences, University of Ulsan, Ulsan, South Korea, Republic of Korea; ⁴Department of Internal Medicine, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, South Korea, Republic of Korea
We previously showed that CCR5 mediates recruitment of NK cells to the kidney after renal ischemia and reperfusion, which in turn induce the production of…

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