Articles tagged "Natural killer cells"

2019 American Transplant Congress
Soluble C Type Lectin Receptor Protein Inhibition of Natural Killer Cell Mediated Tubular Epithelial Cell Death
S. Balaji¹, B. Fuhrmann², D. Lian³, H. Diao³, S. Ma³, Z. Zhang³, A. M. Jevnikar³
¹Physiology, Western University, London, ON, Canada, ²Microbiology and Immunology, Western University, London, ON, Canada, ³London Health Sciences Centre, London, ON, Canada
*Purpose: We have previously shown that Natural Killer (NK) cells can mediate kidney tubular epithelial cell (TEC) death and kidney ischemia-reperfusion injury (IRI) as well…
2019 American Transplant Congress
NK Cell Quantification by Paraffin Immunohistochemistry is Not Predictive of Graft Outcome in 1-Year Surveillance Biopsies
J. Barnes¹, F. Suliman², A. Shammout¹, E. A. Farkash¹
¹Pathology, Michigan Medicine, Ann Arbor, MI, ²Nephrology, Michigan Medicine, Ann Arbor, MI
*Purpose: Molecular and animal studies have identified NK cells as important mediators and markers of antibody mediated rejection. Using three color immunohistochemistry for CD16, T-bet,…
2019 American Transplant Congress
CD56+CD57+ Infiltrate is a Predominant Subset of Infiltrating Natural Killer Cell in Renal Transplant Biopsies with Antibody-Mediated Rejection
H. Jung¹, Y. Wee², J. Kim², M. Choi², J. Choi², H. Kwon², J. Jung², S. Kim³, Y. Cho⁴, Y. Park⁴, H. Go⁴, M. Han⁵, Y. Kim², D. Han², S. Shin²
¹Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology (AMIST), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ²Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ³Department of Convergence Medicine, Asan Institute for life sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁴Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ⁵Department of Clinical Epidemiology, Asan Medical Center, Seoul, Korea, Republic of
*Purpose: To verify a subset of intragraft and circulating natural killer cells associated with kidney allograft rejection and fibrosis.*Methods: Thirty-nine clinically indicated transplant biopsies performed…
2019 American Transplant Congress
Natural Killer Cells Express Significantly More CD16 during Chronic Active Antibody Mediated Rejection Which is Not Caused by a Single Nucleotide Polymorphism within the CD16 Gene
K. Sablik, N. Litjens, A. Peeters, M. Clahsen-van Groningen, M. Klepper, M. Betjes
Erasmus MC, Rotterdam, Netherlands
*Purpose: Chronic-active antibody mediated rejection (c-aABMR) is the leading cause of long-term renal allograft loss. Fc-receptor CD16 bearing natural killer (NK) cells may be involved…
2019 American Transplant Congress
Back Signaling of HLA Class I Molecules and NK Cell Receptor Ligands in Renal Epithelial Cells Contributes to the Rejection-Specific Microenvironment
E. Chichelnitskiy¹, J. Egelkamp¹, K. Daemen¹, J. Keil¹, C. Neudörfl¹, J. Bräsen², J. Schmitz², H. Haller³, C. Blume⁴, C. Falk⁵
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Nephropathology Unit, Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany, ⁴Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; Institute of Technical Chemistry, Leibniz University, Hannover, Germany, ⁵Institute of Transplant Immunology, Hannover Medical School; DZIF, German Center for Infection Research, TTU-IICH, Hannover/Braunschweig, Germany
*Purpose: During the last years, diverse harming mechanisms of donor-specific antibodies (DSA) to endothelial cells have been studied accompanied by an emerging evidence of NK…
2018 American Transplant Congress
Donor-Specific Antibody Mediates Chronic, but Not Acute, Kidney Allograft Rejection in the Absence of Natural Killer Cells
T. Yagisawa, N. Dvorina, A. Valujskikh, W. Baldwin 3rd, R. Fairchild.
Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
The incidence of antibody-mediated kidney graft rejection continues to increase. We previously reported that dysregulated donor-specific antibody (DSA) responses were induced in B6.CCR5-/- mice transplanted…
2018 American Transplant Congress
Peptides Encoded by EBV Latent Cycle Proteins Affect NK Cell Reactivity
B. Mbiribindi, C. Romero Moreno, C. Esquivel, O. Martinez, S. Krams.
Department of Surgery, Stanford University School of Medicine, Stanford, CA.
Introduction: Epstein–Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…
2018 American Transplant Congress
NK Cells with a Lung-Resident Phenotype Represent the Most Prominent Donor Passenger Leukocyte Subset after Clinical Lung Transplantation
C. Falk,¹ R. BellmasSanz,¹ B. Wiegmann,² A-.M. Hitz,¹ K. Bläsing,¹ C. Neudörfl,¹ I. Tudorache,² C. Kühn,² M. Avsar,² A. Haverich,² G. Warnecke.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
ObjectivesDonor passenger leukocytes in peripheral blood of recipients after lung transplantation have been described long time ago. However, kinetics, distribution of T vs. NK cells,…
2018 American Transplant Congress
The Role of NKT Cell /IL-17 Axis in the Autoimmune Lupus Nephritis
J. An,¹ Y. Kim,² M. Yu,² J. Lee,¹ C. Lee,³ Y. Kim,² S. Yang.⁴
¹Internal Medicine, Boramae Medical Center, Seoul, Korea; ²Internal Medicine, Seoul National University Hospital, Seoul, Korea; ³Internal Medicine, Cheju Halla General Hospital, Cheju, Korea; ⁴Internal Medicine, Seoul National University Kidney Research Institute, Seoul, Korea.
CD1d-restrictive NKT cells may modulate various chronic autoimmunity through secreting multiple cytokines, but the functional relationships between the different subpopulation still are poorly understood. The…
2018 American Transplant Congress
NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence
M. Terada,¹ J. Duong Van Huyen,² F. Drieux,⁴ C. Legendre,³ P. Bruneval,¹ M. Rabant.²
¹Pathology Department, Georges Pompidou European Hospital, Paris, France; ²Pathology Department, Necker-Enfants Malades Hospital, Paris, France; ³Kidney Transplantation Department, Necker-Enfants Malades Hospital, Paris, France; ⁴Pathology Department, Centre Henri Becquerel, Rouen, France.
Introduction: Among the complex cellular interplay engaged in renal rejection, recent transcriptomic analysis of renal biopsies has detected NK cell transcripts in the setting of…

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