Articles tagged "Natural killer cells"

2019 American Transplant Congress
Natural Killer Cells Express Significantly More CD16 during Chronic Active Antibody Mediated Rejection Which is Not Caused by a Single Nucleotide Polymorphism within the CD16 Gene
K. Sablik, N. Litjens, A. Peeters, M. Clahsen-van Groningen, M. Klepper, M. Betjes
Erasmus MC, Rotterdam, Netherlands
*Purpose: Chronic-active antibody mediated rejection (c-aABMR) is the leading cause of long-term renal allograft loss. Fc-receptor CD16 bearing natural killer (NK) cells may be involved…
2019 American Transplant Congress
Back Signaling of HLA Class I Molecules and NK Cell Receptor Ligands in Renal Epithelial Cells Contributes to the Rejection-Specific Microenvironment
E. Chichelnitskiy¹, J. Egelkamp¹, K. Daemen¹, J. Keil¹, C. Neudörfl¹, J. Bräsen², J. Schmitz², H. Haller³, C. Blume⁴, C. Falk⁵
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Nephropathology Unit, Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany, ⁴Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; Institute of Technical Chemistry, Leibniz University, Hannover, Germany, ⁵Institute of Transplant Immunology, Hannover Medical School; DZIF, German Center for Infection Research, TTU-IICH, Hannover/Braunschweig, Germany
*Purpose: During the last years, diverse harming mechanisms of donor-specific antibodies (DSA) to endothelial cells have been studied accompanied by an emerging evidence of NK…
2019 American Transplant Congress
CCR5-Mediated Recruitment of NK Cells to the Kidney is a Critical Step for Host Defense to Candida albicans Infection
H. R. Cho¹, V. G. Tran², N. N. Nguyen³, S. Lee⁴, S. W. Kang⁴, J. Kim⁴, H. J. Kim⁴, S. J. Park¹, J. S. Lee⁵, B. Kwon⁶
¹Department of Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of, ²School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea, Ulsan, Korea, Republic of, ³1School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea, Ulsan, Korea, Republic of, ⁴Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ⁵Division of Nephrology, Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of, ⁶Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Korea, Republic of
*Purpose: Candida albicans infection causes a high rate of mortality in immunocompromised or transplant patients. In this study, we investigated the role of CCR5 that…
2019 American Transplant Congress
Broadly Profiling the Activation Status of Circulating Immune Cells in Chronic Active Antibody Mediated Rejetion Reveals Increased CD38 and CD16 Expression on Monocytes and NK Cells
K. Sablik, N. Litjens, M. Klepper, M. Betjes
Erasmus MC, Rotterdam, Netherlands
*Purpose: Chronic-active antibody mediated rejection (c-aABMR) contributes significantly to late renal allograft failure. Non-invasive biomarkers of c-aABMR are currently not available but could be valuable…
2019 American Transplant Congress
EBV Latent Proteins Encode for Peptides That Prevent Natural Killer Cell Inhibition
B. Mbiribindi¹, J. K. Pena¹, O. Hatton², C. Romero Moreno¹, C. O. Esquivel¹, O. M. Martinez¹, S. M. Krams¹
¹Department of Surgery/ Division of Abdominal Transplant, Stanford University - School of Medicine, Stanford, CA, ²Department of Molecular Biology, Colorado College, Colorado Springs, CO
*Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). Although EBV infection…
2018 American Transplant Congress
NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence
M. Terada,¹ J. Duong Van Huyen,² F. Drieux,⁴ C. Legendre,³ P. Bruneval,¹ M. Rabant.²
¹Pathology Department, Georges Pompidou European Hospital, Paris, France; ²Pathology Department, Necker-Enfants Malades Hospital, Paris, France; ³Kidney Transplantation Department, Necker-Enfants Malades Hospital, Paris, France; ⁴Pathology Department, Centre Henri Becquerel, Rouen, France.
Introduction: Among the complex cellular interplay engaged in renal rejection, recent transcriptomic analysis of renal biopsies has detected NK cell transcripts in the setting of…
2018 American Transplant Congress
An In Vitro Model of Human Antibody-Mediated Rejection Depicts Key Role for NK Cells
L. Hidalgo,¹ M. Racape,² A. Loupy,² C. Lefaucheur.²
¹Lab. Med. and Pathology, University of Alberta, Edmonton, AB, Canada; ²Paris Cardiovascular Research Center INSERM, Paris, France.
AIM: Antibody-mediated rejection (ABMR) is the leading cause of kidney allograft loss but its immune mechanisms are incompletely understood. We sought to examine key interactions…
2018 American Transplant Congress
NKG2C+CD57+ NK (G2C+57+) Cells Expanded by CMV Infection Are Highly Responsive to Allo-Antibody (Ab)-Mediated NK Cell Stimulation
B. Shin,¹ D. Puliyanda,² H. Pizzo,² S. Jordan,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Active CMV infection is known to be associated with risk for ABMR in allograft recipients. Ab-dependent cellular cytotoxicity (ADCC) primarily mediated by NK cells…
2018 American Transplant Congress
Regulation of NK Cell Cytotoxicity by TEC Expression of Clr Proteins in Kidney Ischemia Reperfusion Injury (IRI)
B. Fuhrmann,^1,5 D. Lian,⁵ Z. Yin,⁵ S. Ma,^4,5 J. Arp,⁵ Z. Zhang,^2,3,4,5 A. Jevnikar.^1,3,4,5
¹Microbiology and Immunology, Western University, London, Canada; ²Pathology, Western University, London, Canada; ³Medicine, Western University, London, Canada; ⁴Multi-Organ Transplant Program, London Health Sciences Centre, London, Canada; ⁵Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.
Background: Kidney tubular epithelial cells (TEC) may negatively regulate NK cell activation and cytotoxic capacity by surface expression of a novel class of C-type lectin-related…
2018 American Transplant Congress
Th17 and NK Responses Are Differentially Induced in Renal Allografts According to Recipient Murine Cytomegalovirus Dose and Strain
M. Shimamura,¹ M. Li,² S. Boddeda,¹ B. Chen,² Q. Zeng,¹ T. Schoeb,² V. Velazquez.¹
¹Center for Vaccines and Immunity and Dept. of Pediatric Infectious Diseases, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH; ²Depts. of Pediatric Infectious Diseases, Pathology, and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Purpose: To study the impact of cytomegalovirus (CMV) recipient positive (R+) serostatus upon renal allograft injury, murine CMV (MCMV) D+/R+ kidney transplants using recipients infected…

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