Articles tagged "Natural killer cells"

2021 American Transplant Congress
Influence of Immunosuppressive Drug Trough Levels on Nk Cells in Liver Transplantation
R. Qin¹, J. Qin², C. Sun³, B. Nashan¹
¹Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China, ²Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China., Hefei, China, ³Division of Life and Medicine, University of Science and Technology of China, Hefei, China
*Purpose: Natural killer (NK) cells are enriched in lymphocytes within the liver and are considered to be main regulators of liver transplantation (LT) rejection and…
2020 American Transplant Congress
Cardiac Transplantation is Accompanied by Major T and NK Cell Alterations within the First 24 Hours
J. Iske¹, B. Wiegmann², K. Ludwig¹, N. Ledwoch¹, E. Chichelnitskiy¹, J. F. Kühne¹, A. Hitz¹, R. Bellmàs-Sanz¹, K. Daemen¹, J. Keil¹, F. Ius², S. Rochas², A. Knoefel², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Allogeneic heart transplantation (HTx) displays the only curative approach for terminal heart insufficiency while acute allograft rejection remains a major complication. However, early kinetics…
2020 American Transplant Congress
Specific Gut Microbiota Community Suppresses Acute Rejection by Reducing Natural Killer Cell Population
W. Zhang, L. Gong, Y. Xu, X. Hu
Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Urology Institute of Capital Medical University, Beijing, China
*Purpose: The gut microbiota community was reported to be altered by high-dose FK506 treatment, while fecal microbiota transplantation with such microbiota plus low-dose FK506 could…
2020 American Transplant Congress
Sequence Variations of the LMP1 Protein are Detected in Pediatric Transplant Recipients and May Increase the Risk of EBV Disease
B. Mbiribindi¹, M. Arvedson¹, J. Pena¹, O. Hatton², C. Esquivel¹, O. Martinez¹, S. Krams¹
¹Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, ²Molecular Biology, Colorado College, Colorado Springs, CO
*Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). PTLD is a…
2020 American Transplant Congress
Immune Cell Subset Profiles in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)
S. Ge¹, M. Chu¹, A. D. Guzman¹, E. D. Ortiz¹, A. Vo², N. Ammerman², S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6, B cell growth factor, increases follicular T helper cell (Tfh) activity, promoting plasmablast (PB) and plasma cell (PC) differentiation, and antibody production. A…
2020 American Transplant Congress
Immunohistochemical and Molecular Detection of NK Cells in Kidney Allografts with Antibody Mediated Rejection
E. Farkash, J. Barnes, S. Anand
Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Molecular signatures specific to Natural Killer (NK) cells are closely associated with antibody mediated rejection (AMR) in transplant biopsies. We have developed an immunohistochemical…
2020 American Transplant Congress
Analysis of the Mechanism of Liver-Resident NK Cells Activity via the Aryl Hydrocarbon Receptor
K. Sato, M. Ohira, Y. Imaoka, H. Ohdan
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). We previously reported an adoptive immunotherapy approach that…
2020 American Transplant Congress
Examination of the TIGIT/CD226 Axis in Kidney Transplant Recipients
G. J. Kavalam, A. D. Desai, A. Chandraker, S. Tripathi
Renal, Brigham and Women's Hospital, Boston, MA
*Purpose: The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) and CD226, two poliovirus receptor-like proteins, are an emerging group of immune checkpoints with…
2020 American Transplant Congress
Decreased Anti-Tumor Activity of Liver-Resident NK Cells via IL-33 Associated with Portal Hypertension after Living Donor Liver Transplantation
Y. Imaoka, M. Ohira, K. Sato, H. Ohdan
Hiroshima Uni., Hiroshima, Japan
*Purpose: It has been reported that increasing portal vein pressure after living donor liver transplantation (LDLT) was associated with a poor prognosis, risk factors for…
2020 American Transplant Congress
Missing Self Increases the Incidence of Microvascular Inflammation after Kidney Transplantation
J. Callemeyn¹, A. Senev², M. Coemans¹, E. Lerut³, B. Sprangers¹, D. Kuypers¹, A. Koenig⁴, O. Thaunat⁴, M. Emonds², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium, ³Imaging and Pathology, KU Leuven, Leuven, Belgium, ⁴INSERM U1111, Université Claude Bernard Lyon I, Lyon, France
*Purpose: Anti-HLA donor-specific antibodies (HLA-DSA) are often absent in serum of kidney allograft recipients with biopsies demonstrating microvascular inflammation (MVI), the histological hallmark of antibody-mediated…