Articles tagged "Natural killer cells"

2021 American Transplant Congress
CD56^dimCD16^bright NK Cells from Kidney Transplant Recipients with Antibody-mediated Rejection Display Increased Proliferation, Type-1 Activation and Cytotoxic Profile
E. Bailly¹, C. Macedo¹, K. Louis¹, B. Ramaswami¹, M. Lucas¹, C. Bentlejewski¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Université de Paris, Paris, France
*Purpose: CD56dimCD16bright NK cells are highly potent for cytotoxicity through cell-mediated cytotoxicity (CMC), antibody-dependent cell-mediated cytotoxicity (ADCC) and INF-γ production. The contribution of NK cells…
2020 American Transplant Congress
Single Cell Profiling of PBMC Identifies Immune Populations Associated with High Risk of Early Acute Rejection
W. Zhang, S. Farouk, Z. Sun, W. Huang, Z. Yi, J. Fu, C. Wei, M. Fribourg-Casajuana, C. He, P. Cravedi, B. Murphy
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Our previous transcriptomic analysis of pre-transplant peripheral blood revealed a 23-gene set predictive of early acute rejection (EAR) post kidney transplant (JCI Insight, 2019).…
2020 American Transplant Congress
Adjuvant Immunotherapy for Liver Transplant Recipients with Hepatocellular Carcinoma Using Donor Liver Derived Natural Killer Cells
M. Ohira¹, R. Hotta¹, Y. Imaoka¹, K. Sato¹, N. Tanimine¹, H. Tahara¹, K. Ide¹, T. Kobayashi¹, Y. Tanaka¹, A. Tzakis², S. Nishida², H. Ohdan¹
¹Hiroshima University, Hiroshima, Japan, ²University of Miami, Miami, FL
*Purpose: Development of an effective adjuvant therapy to prevent HCC recurrence after liver transplantation (LT) is an important medical requirement. Immunosuppressive regimens currently used after…
2020 American Transplant Congress
Evaluation of Host Immune Responses to Epstein-Barr Virus in Lung Transplant Recipients
L. Zaffiri¹, J. E. Messinger², J. Yi², K. J. Weinhold², G. Ferrari², M. Luftig², S. M. Palmer¹
¹Pulmonary and Critical Care, Duke University, Durham, NC, ²Duke University, Durham, NC
*Purpose: After lung transplantation, Epstein-Barr virus (EBV) is a common opportunistic infection. The significance of EBV viremia following solid organ transplantation (SOT) remains unclear. Host…
2020 American Transplant Congress
Cell-Free DNA (cfDNA) is Released by Necroptosis and Promotes Kidney Ischemia Reperfusion Injury
A. C. Dionne
Microbiology and Immunology, Western University, London, ON, Canada
*Purpose: Transplantation is invariably associated with ischemia reperfusion injury (IRI) which causes organ dysfunction. IRI is also directly linked to several forms of programmed cell…
2020 American Transplant Congress
Cardiac Transplantation is Accompanied by Major T and NK Cell Alterations within the First 24 Hours
J. Iske¹, B. Wiegmann², K. Ludwig¹, N. Ledwoch¹, E. Chichelnitskiy¹, J. F. Kühne¹, A. Hitz¹, R. Bellmàs-Sanz¹, K. Daemen¹, J. Keil¹, F. Ius², S. Rochas², A. Knoefel², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Allogeneic heart transplantation (HTx) displays the only curative approach for terminal heart insufficiency while acute allograft rejection remains a major complication. However, early kinetics…
2020 American Transplant Congress
Specific Gut Microbiota Community Suppresses Acute Rejection by Reducing Natural Killer Cell Population
W. Zhang, L. Gong, Y. Xu, X. Hu
Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Urology Institute of Capital Medical University, Beijing, China
*Purpose: The gut microbiota community was reported to be altered by high-dose FK506 treatment, while fecal microbiota transplantation with such microbiota plus low-dose FK506 could…
2020 American Transplant Congress
Sequence Variations of the LMP1 Protein are Detected in Pediatric Transplant Recipients and May Increase the Risk of EBV Disease
B. Mbiribindi¹, M. Arvedson¹, J. Pena¹, O. Hatton², C. Esquivel¹, O. Martinez¹, S. Krams¹
¹Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, ²Molecular Biology, Colorado College, Colorado Springs, CO
*Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). PTLD is a…
2020 American Transplant Congress
Immune Cell Subset Profiles in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)
S. Ge¹, M. Chu¹, A. D. Guzman¹, E. D. Ortiz¹, A. Vo², N. Ammerman², S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6, B cell growth factor, increases follicular T helper cell (Tfh) activity, promoting plasmablast (PB) and plasma cell (PC) differentiation, and antibody production. A…
2020 American Transplant Congress
Immunohistochemical and Molecular Detection of NK Cells in Kidney Allografts with Antibody Mediated Rejection
E. Farkash, J. Barnes, S. Anand
Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Molecular signatures specific to Natural Killer (NK) cells are closely associated with antibody mediated rejection (AMR) in transplant biopsies. We have developed an immunohistochemical…