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Articles tagged "Natural killer cells"

  • 2022 American Transplant Congress

    NK Cells in Kidney Allograft Antibody-mediated Rejection Display Increased Proliferation, IL-21 Responsiveness, Type-1 Activation, and Cytotoxic Profile

    E. Bailly1, C. Macedo1, K. Louis2, X. Gu1, B. Ramaswami1, M. Lucas1, C. Bentlejewski1, A. Zeevi1, P. Randhawa1, C. Lefaucheur2, D. Metes1

    1Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, 2INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Paris, France

    *Purpose: The role of NK cell during antibody-mediated rejection (ABMR) has been previously recognized, but an in-depth characterization of pathways that contribute to such immune…
  • 2021 American Transplant Congress

    Human Liver-derived Mesenchymal Stromal Cells (MSC) are Superior Inhibitors of Natural Killer Cells Compared to Bone Marrow or Adipose Tissue-derived MSC

    F. Yigitbilek, M. J. Hansen, W. D. Park, M. D. Stegall, T. Taner

    Mayo Clinic, Rochester, MN

    *Purpose: Guided by the liver allografts’ unique tolerogenic microenvironment and the immunoprotective impact on simultaneously transplanted organs, we recently isolated liver mesenchymal stromal cells (L-MSC)…
  • 2021 American Transplant Congress

    Portal Hypertension Abrogates Trail Expression of Liver Resident Nk Cells via Il-33

    Y. Imaoka, M. Ohira, K. Sato, H. Ohdan

    Hiroshima Uni., Hiroshima, Japan

    *Purpose: Portal vein hypertension (PHT) is associated with poor prognosis, risk factors for small graft syndrome, bloodstream infection, and acute rejection after living donor liver…
  • 2021 American Transplant Congress

    Recipient Neutrophils Producing Myeloperoxidase Provoke Nk Cell and Monocyte/macrophage Activation During Acute Antibody-mediated Rejection of Kidney Allografts

    D. Ueda, S. Miyairi, K. Keslar, W. M. Baldwin, R. L. Fairchild

    Lerner Research Institute, Cleveland Clinic, Cleveland, OH

    *Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and mediate acute graft rejection. Acute…
  • 2021 American Transplant Congress

    Influence of Immunosuppressive Drug Trough Levels on Nk Cells in Liver Transplantation

    R. Qin1, J. Qin2, C. Sun3, B. Nashan1

    1Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China, 2Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China., Hefei, China, 3Division of Life and Medicine, University of Science and Technology of China, Hefei, China

    *Purpose: Natural killer (NK) cells are enriched in lymphocytes within the liver and are considered to be main regulators of liver transplantation (LT) rejection and…
  • 2021 American Transplant Congress

    Tissue-Specific Features of Immunity Revealed by Single-cell RNA Sequencing of Healthy Human Kidney

    S. Q. Crome1, J. M. Szusz2, C. McEvoy1, J. An1, S. Clotet-Freixas1, S. A. MacParland1, G. D. Bader3, A. Konvalinka1

    1Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network and the University of Toronto, Toronto, ON, Canada, 2Immunology, University of Toronto, Toronto, ON, Canada, 3Molecular Genetics, University of Toronto, Toronto, ON, Canada

    *Purpose: Tissue-resident immune cells reside within distinct niches across organs, where they sustain tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Across…
  • 2021 American Transplant Congress

    Donor Lymphocytes in Peripheral Blood of Patients After Lung Transplantation Comprise High Frequencies of Killer Cell Immunoglobulin-like Receptor-positive T and NK Cell Subsets

    J. F. Kühne1, A. Hitz1, K. A. Bläsing1, B. Wiegmann2, R. Bellmàs Sanz1, F. Ius2, A. Haverich2, G. Warnecke2, C. S. Falk1

    1MHH, Institute of Transplant Immunology, Hannover, Germany, 2MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany

    *Purpose: For end-stage lung diseases, lung transplantation (LuTx) is the only curative treatment option. However, acute and chronic rejections are major limitations. Thus, a deeper…
  • 2021 American Transplant Congress

    Adjuvant Immunotherapy for Liver Transplant Recipients with Hepatocellular Carcinoma Using Donor Liver-derived Natural Killer Cells

    M. Ohira1, R. Hotta1, Y. Imaoka1, K. Sato1, N. Tanimine1, Y. Tanaka1, S. Nishida2, A. Tzakis2, H. Ohdan1

    1Hiroshima University, Hiroshima, Japan, 2University of Miami, Miami, FL

    *Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is an indication for liver transplantation (LT). Immunosuppressive regimens currently used after…
  • 2021 American Transplant Congress

    The Effect of Daratumumab (Dara, Humanized Anti-CD38 Monoclonal Antibody) on Immune Cells In Vitro and in a HLA-Sensitized Kidney Transplant Patient (HS KTx Pt) Desensitized (DES) with Dara

    S. Ge1, M. Chu1, A. De Guzman1, E. Ortiz1, A. Vo2, N. Ammerman2, S. C. Jordan2, M. Toyoda1

    1Transplant Immunology Laboratory, Cedars Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA

    *Purpose: Antibody-Mediated Rejection (ABMR), primarily mediated by B cells, plasma cells (PC) and antibodies (Ab), is an obstacle for successful transplantation in HS KTx Pts.…
  • 2021 American Transplant Congress

    Cd4 T Cells Can Trigger Nk-dependent Chronic Rejection Independent of Antibodies

    R. G. Gill1, B. Mehrad2, C. M. Lin2

    1Surgery, University of Colorado Denver, Aurora, CO, 2Medicine, University of Florida, Gainesville, FL

    *Purpose: In transplantation, recipient CD4+ T cells have two potential means of MHC class II-restricted donor antigen detection: (1) the direct recognition of allogeneic MHC…
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