Articles tagged "Natural killer cells"

2022 American Transplant Congress
Natural Killer Cell NKG2D Receptor Mediates Airway Cell Hypoxic Injury Through Recognition of Stress Molecules
T. Tsao¹, E. Aminian¹, A. Shemesh¹, L. Tran¹, P. Wang¹, F. Deiter¹, J. R. Greenland², D. R. Calabrese¹
¹University of California, San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, CA
*Purpose: Primary graft dysfunction (PGD), the clinical syndrome of pulmonary hypoxia and reperfusion, occurs afer 1/3 of all lung transplants, and accounts for excess mortality.…
2021 American Transplant Congress
Adjuvant Immunotherapy for Liver Transplant Recipients with Hepatocellular Carcinoma Using Donor Liver-derived Natural Killer Cells
M. Ohira¹, R. Hotta¹, Y. Imaoka¹, K. Sato¹, N. Tanimine¹, Y. Tanaka¹, S. Nishida², A. Tzakis², H. Ohdan¹
¹Hiroshima University, Hiroshima, Japan, ²University of Miami, Miami, FL
*Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is an indication for liver transplantation (LT). Immunosuppressive regimens currently used after…
2021 American Transplant Congress
The Effect of Daratumumab (Dara, Humanized Anti-CD38 Monoclonal Antibody) on Immune Cells In Vitro and in a HLA-Sensitized Kidney Transplant Patient (HS KTx Pt) Desensitized (DES) with Dara
S. Ge¹, M. Chu¹, A. De Guzman¹, E. Ortiz¹, A. Vo², N. Ammerman², S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Antibody-Mediated Rejection (ABMR), primarily mediated by B cells, plasma cells (PC) and antibodies (Ab), is an obstacle for successful transplantation in HS KTx Pts.…
2021 American Transplant Congress
Cd4 T Cells Can Trigger Nk-dependent Chronic Rejection Independent of Antibodies
R. G. Gill¹, B. Mehrad², C. M. Lin²
¹Surgery, University of Colorado Denver, Aurora, CO, ²Medicine, University of Florida, Gainesville, FL
*Purpose: In transplantation, recipient CD4+ T cells have two potential means of MHC class II-restricted donor antigen detection: (1) the direct recognition of allogeneic MHC…
2021 American Transplant Congress
CD56^dimCD16^bright NK Cells from Kidney Transplant Recipients with Antibody-mediated Rejection Display Increased Proliferation, Type-1 Activation and Cytotoxic Profile
E. Bailly¹, C. Macedo¹, K. Louis¹, B. Ramaswami¹, M. Lucas¹, C. Bentlejewski¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Université de Paris, Paris, France
*Purpose: CD56dimCD16bright NK cells are highly potent for cytotoxicity through cell-mediated cytotoxicity (CMC), antibody-dependent cell-mediated cytotoxicity (ADCC) and INF-γ production. The contribution of NK cells…
2021 American Transplant Congress
Human Liver-derived Mesenchymal Stromal Cells (MSC) are Superior Inhibitors of Natural Killer Cells Compared to Bone Marrow or Adipose Tissue-derived MSC
F. Yigitbilek, M. J. Hansen, W. D. Park, M. D. Stegall, T. Taner
Mayo Clinic, Rochester, MN
*Purpose: Guided by the liver allografts’ unique tolerogenic microenvironment and the immunoprotective impact on simultaneously transplanted organs, we recently isolated liver mesenchymal stromal cells (L-MSC)…
2021 American Transplant Congress
Portal Hypertension Abrogates Trail Expression of Liver Resident Nk Cells via Il-33
Y. Imaoka, M. Ohira, K. Sato, H. Ohdan
Hiroshima Uni., Hiroshima, Japan
*Purpose: Portal vein hypertension (PHT) is associated with poor prognosis, risk factors for small graft syndrome, bloodstream infection, and acute rejection after living donor liver…
2021 American Transplant Congress
Recipient Neutrophils Producing Myeloperoxidase Provoke Nk Cell and Monocyte/macrophage Activation During Acute Antibody-mediated Rejection of Kidney Allografts
D. Ueda, S. Miyairi, K. Keslar, W. M. Baldwin, R. L. Fairchild
Lerner Research Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and mediate acute graft rejection. Acute…
2021 American Transplant Congress
Influence of Immunosuppressive Drug Trough Levels on Nk Cells in Liver Transplantation
R. Qin¹, J. Qin², C. Sun³, B. Nashan¹
¹Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China, ²Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China., Hefei, China, ³Division of Life and Medicine, University of Science and Technology of China, Hefei, China
*Purpose: Natural killer (NK) cells are enriched in lymphocytes within the liver and are considered to be main regulators of liver transplantation (LT) rejection and…
2021 American Transplant Congress
Tissue-Specific Features of Immunity Revealed by Single-cell RNA Sequencing of Healthy Human Kidney
S. Q. Crome¹, J. M. Szusz², C. McEvoy¹, J. An¹, S. Clotet-Freixas¹, S. A. MacParland¹, G. D. Bader³, A. Konvalinka¹
¹Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network and the University of Toronto, Toronto, ON, Canada, ²Immunology, University of Toronto, Toronto, ON, Canada, ³Molecular Genetics, University of Toronto, Toronto, ON, Canada
*Purpose: Tissue-resident immune cells reside within distinct niches across organs, where they sustain tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Across…