2015 American Transplant Congress
Analysis of In-Vitro Effects of Immunosuppression on NK Cell Subsets in the Presence of Cytomegalovirus
Background: NK cells may play an important role in the control of CMV replication post-transplant. NK cells can be divided into subsets based on surface…2015 American Transplant Congress
IL-2-Dependent Natural Killer Cell Responses to Epstein-Barr Virus B Cell Lymphomas Involve the NKG2A/NKG2C Axis
Stanford University School of Medicine, Stanford, CA.
Epstein Barr virus (EBV) infection elicits a strong host immune response that is considered to be essential for control of the virus and for preventing…2015 American Transplant Congress
CD27low NK Cells Prolong Allograft Survival in Mice By Inhibiting CD8+ T Cell Responses Through Controlling Graft-Derived Donor DCs
The underlying mechanisms by which distinct NK cell subsets promote either allograft rejection or survival remain unclear. Here, we tested the hypothesis that distinctively mature…2015 American Transplant Congress
Recipient Immunity to Murine Cytomegalovirus Influences Natural Killer Cell Responses in Infected Renal Allografts
BACKGROUND: Human cytomegalovirus (CMV) is associated epidemiologically with renal allograft loss, but the impact of recipient CMV immunity upon graft survival is unclear. Natural killer…2015 American Transplant Congress
Immunological Aspects of Iron Overload in Heart and Kidney Transplantation
Background: Clinical data suggest that iron (Fe) overload deleteriously affects graft survival after heart (HTX) and kidney transplantation (KTX) but possible immunologic mechanisms underlying this…2015 American Transplant Congress
NK-Cell Subset Distribution, Renal Function and Biopsy Findings in Kidney Transplant Recipients With HLA Donor-Specific Antibodies
Background: Detection of post-transplant donor-specific anti-HLA antibodies(DSA) constitutes a risk factor for kidney transplant (KT) loss. NK-cell antibody-dependent cell mediated cytotoxicity(ADCC) has been proposed to…2015 American Transplant Congress
ILC1 and ILC3 Are the Predominant Intra-Epithelial Lymphoid Populations in Human Small Bowel Grafts
We have shown that differently from native small bowels, NK-like cells (CD45+CD103+CD3-) are the predominant intra-epithelial lymphocytes (IEL) in small bowel grafts (SBG) from 4th…2015 American Transplant Congress
Mesenchymal Stem Cells Suppress Cytotoxicity of Activated Natural Killer Cells in Liver Via the TRAIL-TRAIL Receptor Pathway in Islet Transplantation
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Introduction: Innate immune reactions against islet grafts are considered a major obstacle for intraportal islet transplantation. We have previously reported that liver natural killer (NK)…2015 American Transplant Congress
Adoptive Immunotherapy Using Activated NK Cells Ameliorates the FcγRIIIa Gene Polymorphism-Associated Susceptibility to Post Transplant Bloodstream Infection
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Background: At ATC 2014, we demonstrated that detection of single nucleotide polymorphisms (SNP) of FcγRIIIa helps predict the susceptibility of liver transplant (LT) recipients to…2015 American Transplant Congress
Host NK Cell Allorecognition of Passenger Donor Lymphocytes Within Allografts Is Essential for Preventing Augmentation of Recipient Adaptive Alloimmunity
Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
Background:Memory T cells are now appreciated to reside in peripheral non-lymphoid tissue, but how their presence within solid organ allografts impacts upon transplant outcomes is…
American Transplant Congress abstracts