2015 American Transplant Congress
NKp46 Clusters at the NK Cell Immune Synapse Regulate Specific Effector Functions
1Stanford University, Stanford, CA; 2Ben Gurion University of the Negev, Beer Sheva, Israel.
Natural Killer (NK) cells play an important role in the first-line defense against tumor and virus-infected cells. Studies suggest NK cells have a dichotomous role…2015 American Transplant Congress
The Influence of Immunosuppressive Drugs On the Epithelial Microenvironment in Solid Organ Transplantation – Identification of Biomarker Candidates for Rejection Vs. Tolerance
In the context of kidney transplantation, NK cells may play an important role by targeting the allogeneic organ due to "missing-self recognition", which leads to…2015 American Transplant Congress
Adoptive Immunotherapy With Liver Allograft-Derived NK Cells Improves Recurrence-Free Survival After Living-Donor Liver Transplantation in Patients With Hepatocellular Carcinoma
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Introduction: Previous studies revealed that the recurrence rate of hepatocellular carcinoma (HCC) was still 10–20%, even among liver transplantation (LT) recipients meeting the Milan criteria…2015 American Transplant Congress
NK Cells of Kidney Transplant Recipients Show a Reduced Capacity to Produce Cytokines But Retain Their Cytotoxic Capacity
The role of NK cells in either graft rejection or tolerance induction is still discussed controversially. In order to clarify the effect of long-term immunosuppression…2015 American Transplant Congress
Analysis of In-Vitro Effects of Immunosuppression on NK Cell Subsets in the Presence of Cytomegalovirus
Background: NK cells may play an important role in the control of CMV replication post-transplant. NK cells can be divided into subsets based on surface…2015 American Transplant Congress
IL-2-Dependent Natural Killer Cell Responses to Epstein-Barr Virus B Cell Lymphomas Involve the NKG2A/NKG2C Axis
Stanford University School of Medicine, Stanford, CA.
Epstein Barr virus (EBV) infection elicits a strong host immune response that is considered to be essential for control of the virus and for preventing…2015 American Transplant Congress
CD27low NK Cells Prolong Allograft Survival in Mice By Inhibiting CD8+ T Cell Responses Through Controlling Graft-Derived Donor DCs
The underlying mechanisms by which distinct NK cell subsets promote either allograft rejection or survival remain unclear. Here, we tested the hypothesis that distinctively mature…2015 American Transplant Congress
Recipient Immunity to Murine Cytomegalovirus Influences Natural Killer Cell Responses in Infected Renal Allografts
BACKGROUND: Human cytomegalovirus (CMV) is associated epidemiologically with renal allograft loss, but the impact of recipient CMV immunity upon graft survival is unclear. Natural killer…2015 American Transplant Congress
Immunological Aspects of Iron Overload in Heart and Kidney Transplantation
Background: Clinical data suggest that iron (Fe) overload deleteriously affects graft survival after heart (HTX) and kidney transplantation (KTX) but possible immunologic mechanisms underlying this…2015 American Transplant Congress
NK-Cell Subset Distribution, Renal Function and Biopsy Findings in Kidney Transplant Recipients With HLA Donor-Specific Antibodies
Background: Detection of post-transplant donor-specific anti-HLA antibodies(DSA) constitutes a risk factor for kidney transplant (KT) loss. NK-cell antibody-dependent cell mediated cytotoxicity(ADCC) has been proposed to…
American Transplant Congress abstracts