ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Natural killer cells"

  • 2022 American Transplant Congress

    Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration

    A. Buxeda1, L. Llinàs-Mallol1, J. Gimeno2, D. Redondo-Pachón1, C. Arias-Cabrales1, C. Burballa1, A. Puche2, M. Pérez-Sáez1, J. Pascual3, M. Crespo1

    1Nephrology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, 2Pathology Department, Hospital del Mar, Institute Mar for Medical Research (IMIM), Barcelona, Spain, 3Nephrology Department, Hospital Universitario 12 de Octubre. Institute Mar for Medical Research (IMIM), Madrid, Spain

    *Purpose: Microvascular inflammation (MVI) without evidence of HLA-donor-specific antibodies (HLA-DSA) or C4d+ deposition remains an enigmatic phenotype, which cannot be classified as antibody-mediated rejection (ABMR)…
  • 2022 American Transplant Congress

    Recipient Treatment with Anti-CD122 mAb Prolongs Kidney Allograft Survival During Antibody-Mediated Rejection without Impacting NK Cell Activation within the Graft

    D. Okada, S. Miyairi, N. Dvorina, K. S. Keslar, A. Valujskikh, W. Baldwin, R. Fairchild

    Cleveland Clinic, Cleveland, OH

    *Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched kidney allografts and are required for rejection of the…
  • 2022 American Transplant Congress

    Natural Killer Cell NKG2D Receptor Mediates Airway Cell Hypoxic Injury Through Recognition of Stress Molecules

    T. Tsao1, E. Aminian1, A. Shemesh1, L. Tran1, P. Wang1, F. Deiter1, J. R. Greenland2, D. R. Calabrese1

    1University of California, San Francisco, San Francisco, CA, 2Medicine, University of California, San Francisco, CA

    *Purpose: Primary graft dysfunction (PGD), the clinical syndrome of pulmonary hypoxia and reperfusion, occurs afer 1/3 of all lung transplants, and accounts for excess mortality.…
  • 2022 American Transplant Congress

    Clinical Efficacy of Adjuvant Immunotherapy for Liver Transplant Recipients with Exceeding Japan Criteria of Hepatocellular Carcinoma Using Donor Liver Derived Natural Killer Cells

    M. Ohira1, Y. Imaoka2, K. Sato3, K. Imaoka1, N. Tanimine1, H. Tahara1, K. Ide1, T. Kobayashi1, Y. Tanaka1, A. G. Tzakis4, S. Nishida5, H. Ohdan1

    1Hiroshima University, Hiroshima, Japan, 2Hiroshima Uni., Hiroshima, Japan, 3Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan, 4Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH, 5Univ of Miami School of Medicine, Valhalla, NY

    *Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is an indication for liver transplantation (LT). Immunosuppressive regimens currently used after…
  • 2022 American Transplant Congress

    RNA-Sequencing Analysis of Kidney Allografts Reveal Heightened NK Cell Activity in Chronic Active Antibody-Mediated Rejection

    Y. Shah, E. Varma, S. Rahim, C. Li, C. Snopkowski, C. Hughes, D. M. Dadhania, S. Salvatore, S. V. Seshan, O. Elemento, M. Suthanthiran, T. Muthukumar

    Weill Cornell Medicine, New York, NY

    *Purpose: The role of NK cells is increasingly recognized in chronic active antibody mediated rejection (caABMR) of the kidney allograft. Treatment of caABMR is challenging…
  • 2022 American Transplant Congress

    Role for Club Cell Secretory Protein in Inducing Exosomes and Activation of Immune Responses in Lung Transplanted Recipients for Cystic Fibrosis

    R. Ravichandran1, V. Kaza2, R. Bremner1, M. Smith1, T. Mohanakumar1

    1St. Joseph’s Hospital and Medical Center, Phoenix, AZ, 2University of Texas Southwestern, Dallas, TX

    *Purpose: Our lab has demonstrated that lower club cell secretory protein leads to immune responses to donor HLA and lung self-antigens (Collagen V, Kα1 Tubulin),…
  • 2022 American Transplant Congress

    Influence of Immunosuppressive Drugs on Nk Cells in Therapeutic Drug Exposured

    R. r. Qin1, C. Sun2, B. Nashan1

    1Division of Life and Medicine, University of Science and Technology of China/The First affiliated hospital of University of Science and Technology of China, Hefei, China, 2Division of Life and Medicine, University of Science and Technology of China, Hefei, China

    *Purpose:Natural killer (NK) cells as part of the innate immune system are residing in the liver and are considered to be main regulators in alloimmune…
  • 2022 American Transplant Congress

    Atherosclerosis Reduces Anti-Tumor Activity of Liver-Resident Natural Killer Cells

    K. Imaoka, M. Ohira, K. Sato, Y. Imaoka, R. Nakano, H. Ohdan

    Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

    *Purpose: Abdominal aorta calcification (AAC) is associated with an increased relative risk of coronary events, cerebrovascular events, cardiovascular events, and cardiovascular death. We report that…
  • 2022 American Transplant Congress

    Understanding the Heterogeneity of Alloreactive Natural Killer (NK) Cell Function in Kidney Transplant Recipients

    D. Ruan, M. Fribourg, N. Chun, P. Cravedi, A. Horowitz, P. Heeger

    Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: Emerging evidence indicates that human NK cells are a heterogeneous population of lymphocytes that are activated upon ligation of one or more activating receptors…
  • 2022 American Transplant Congress

    Portal Hypertension Inhibits the Antitumor Effect of Liver-Resident NK Cells Through IL-33 Signal

    Y. Imaoka, M. Ohira, K. Sato, K. Imaoka, R. Nakano, Y. Tanaka, H. Ohdan

    Hiroshima University, Hiroshima, Japan

    *Purpose: Portal vein hypertension (PHT) after living donor liver transplantation (LDLT) is known to have associated with poor prognosis. Among patients with hepatocellular carcinoma (N=…
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