2022 American Transplant Congress
Clinical Efficacy of Adjuvant Immunotherapy for Liver Transplant Recipients with Exceeding Japan Criteria of Hepatocellular Carcinoma Using Donor Liver Derived Natural Killer Cells
*Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is an indication for liver transplantation (LT). Immunosuppressive regimens currently used after…2022 American Transplant Congress
RNA-Sequencing Analysis of Kidney Allografts Reveal Heightened NK Cell Activity in Chronic Active Antibody-Mediated Rejection
Weill Cornell Medicine, New York, NY
*Purpose: The role of NK cells is increasingly recognized in chronic active antibody mediated rejection (caABMR) of the kidney allograft. Treatment of caABMR is challenging…2022 American Transplant Congress
Role for Club Cell Secretory Protein in Inducing Exosomes and Activation of Immune Responses in Lung Transplanted Recipients for Cystic Fibrosis
*Purpose: Our lab has demonstrated that lower club cell secretory protein leads to immune responses to donor HLA and lung self-antigens (Collagen V, Kα1 Tubulin),…2022 American Transplant Congress
Influence of Immunosuppressive Drugs on Nk Cells in Therapeutic Drug Exposured
*Purpose:Natural killer (NK) cells as part of the innate immune system are residing in the liver and are considered to be main regulators in alloimmune…2022 American Transplant Congress
Atherosclerosis Reduces Anti-Tumor Activity of Liver-Resident Natural Killer Cells
*Purpose: Abdominal aorta calcification (AAC) is associated with an increased relative risk of coronary events, cerebrovascular events, cardiovascular events, and cardiovascular death. We report that…2022 American Transplant Congress
Understanding the Heterogeneity of Alloreactive Natural Killer (NK) Cell Function in Kidney Transplant Recipients
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Emerging evidence indicates that human NK cells are a heterogeneous population of lymphocytes that are activated upon ligation of one or more activating receptors…2022 American Transplant Congress
Portal Hypertension Inhibits the Antitumor Effect of Liver-Resident NK Cells Through IL-33 Signal
Hiroshima University, Hiroshima, Japan
*Purpose: Portal vein hypertension (PHT) after living donor liver transplantation (LDLT) is known to have associated with poor prognosis. Among patients with hepatocellular carcinoma (N=…2022 American Transplant Congress
NK Cells in Kidney Allograft Antibody-mediated Rejection Display Increased Proliferation, IL-21 Responsiveness, Type-1 Activation, and Cytotoxic Profile
*Purpose: The role of NK cell during antibody-mediated rejection (ABMR) has been previously recognized, but an in-depth characterization of pathways that contribute to such immune…2022 American Transplant Congress
Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration
*Purpose: Microvascular inflammation (MVI) without evidence of HLA-donor-specific antibodies (HLA-DSA) or C4d+ deposition remains an enigmatic phenotype, which cannot be classified as antibody-mediated rejection (ABMR)…2022 American Transplant Congress
Recipient Treatment with Anti-CD122 mAb Prolongs Kidney Allograft Survival During Antibody-Mediated Rejection without Impacting NK Cell Activation within the Graft
Cleveland Clinic, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched kidney allografts and are required for rejection of the…
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