2022 American Transplant Congress
Neutrophil CEACAM1 Regulates Extracellular Trap Formation via Non-Canonical Inflammasome Signaling and Impacts Liver Transplantation in Mouse and Human
*Purpose: Neutrophil extracellular trap (NET) formation relates to various diseases, including sterile inflammation. Although neutrophils express proficient CEACAM1 (CC1, also known as CD66a) long isoform,…2017 American Transplant Congress
Signal Inhibitory Regulatory Protein-α Regulates Pathologic Reactive Oxygen Species in Acute Kidney Injury.
Background: Ischemia reperfusion injury (IRI) is mediated by a complex cascade of pro-inflammatory and oxidative processes. We have reported that signal regulatory inhibitory protein (SIRP)-α…2017 American Transplant Congress
Nox4 and Oxidative Stress Mediate TGF-β1 Induced Human Kidney Proximal Cell Apoptosis in Ischemic Reperfusion Injury.
AimsIschemia/reperfusion injury, resulting from hypoxic damage within a graft, is the leading cause of cell death and graft rejection. In this study, we investigated whether…2015 American Transplant Congress
Alloantibody-Dependent Macrophage-Mediated Hepatocellular Damage Is Dependent on FcγRI, FcγRIII, and Reactive Oxygen Species
Dept of Surgery, CTC, The Ohio State University Wexner Medical Center, Columbus, OH.
Alloantibodies (alloAb) play a critical role in rejection after transplantation. Despite this, the cellular mechanisms contributing to alloAb-mediated allograft damage are not well understood. Using…
American Transplant Congress abstracts