2022 American Transplant Congress
Urine-based Assay For Detection Of Acute Rejection In Pediatric Kidney Transplant Recipients
*Purpose: Biomarkers such as donor-derived cell free DNA (cfDNA) and gene expression profiling are utilized in adult transplant patients (pts), but these tests lack sensitivity…2022 American Transplant Congress
Absolute Quantification of Donor-Derived Cell-Free DNA Does Not Provide Additional Discriminating Power Over Donor-derived Cell-Free DNA Fraction for Detection of Allograft Rejection
*Purpose: High level of background cell-free DNA (cfDNA) has been hypothesized as a concern for false negative results in molecular diagnostics for allograft rejection that…2022 American Transplant Congress
Longitudinal Analysis of Donor-Derived Cell-Free DNA (dd-cfDNA) in En-Bloc Kidney Transplantation
*Purpose: The longitudinal dd-cfDNA patterns in en-bloc kidney transplant recipients have not been studied. It is unknown how the initial smaller mass of the two…2022 American Transplant Congress
Therapeutic Drug Monitoring of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Patients
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Lung transplant patients are at an increased risk for invasive fungal infections and often require prophylaxis post-transplant, routinely including posaconazole at our institution. These…2022 American Transplant Congress
Effect Of The SRTR COVID-19 3-month Carve-out On Program-specific Transplant Outcome Evaluations
*Purpose: The SRTR January 2022 program evaluations (Jan 2022 program-specific reports [PSRs]) applied a COVID-19 carve-out where follow-up for transplants performed before March 13, 2020,…2022 American Transplant Congress
BK Polyomavirus Infection is Not Associated with a Meaningful Increase in Donor-Derived Cell-Free DNA
1Warren Alpert Medical School of Brown University, Providence, RI, 2CareDx, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a non-invasive measure of early allograft injury that has been clinically validated as a surveillance tool to detect antibody…2021 American Transplant Congress
Donor-Derived Cell-Free DNA Performance Characteristics are Similar for Repeat and Primary Kidney Transplant Recipients
*Purpose: Repeat kidney transplants (RKT) represent 12.4% of kidney transplants (KT) (10.9% of all living donor and 13.6% of all deceased donor). Most RKT are…2021 American Transplant Congress
Polyfunctional T-cell Impairment to Sars-cov-2 Coronavirus in Solid Organ Transplant Recipients with Acute Covid-19 Infection
*Purpose: The emerged COVID-19 pandemic caused by SARS-CoV-2 has paralyzed the world, due to its high infectivity and fatal outcomes, especially among more vulnerable individuals.…2021 American Transplant Congress
The Role of the B2 Microglobulin Trend in Patients with Delayed Graft Function After Kidney Transplant
Surgery, University of Chicago, Chicago, IL
*Purpose: Delayed graft function (DGF) is associated with worse short and long-term outcomes after kidney transplantation. There is a lack of biomarkers to predict outcomes…2021 American Transplant Congress
Changes to Adult Heart Allocation Improve Candidate Stratification
*Purpose: Historically, heart allocation has been driven by waitlist (WL) mortality rather than post-transplant survival. On 10/18/2018 the Organ Procurement and Transplantation Network (OPTN) implemented…
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