Articles tagged "Monitoring"

2022 American Transplant Congress
Biological Functions of Circulating miRNAs in Patients with Chronic Pancreatitis Undergoing Total Pancreatectomy with Islet Autotransplantation
S. Vasu¹, C. Darden², Y. Liu³, M. Lawrence⁴, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University, Waco, TX, ³-Baylor University Medical Center, Dallas, TX, ⁴Baylor University Medical Center, Dallas, TX
*Purpose: Our previous reports showed that in patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after…
2022 American Transplant Congress
Utility of a Holistic Molecular Paradigm for Kidney Biopsy in the Clinic
S. Anand¹, J. Sanchez-Garcia¹, K. Qui², K. Pinney², A. Raza¹, T. Srinivas², D. Morris¹
¹Intermountain Medical Center, Murray, UT, ²CareDX, South San Francisco, CA
*Purpose: We report on the clinical utility of a serial dd-cfDNA (donor derived cell free DNA) monitoring coupled with Tissue Transcriptomics (Tr) and Histology (Hx)…
2022 American Transplant Congress
The Trajectory of Donor-Derived Cell-Free DNA (dd-cfDNA) Complements the Baseline Measurements in Heart Transplant Surveillance for Rejection
P. Shah¹, R. Cheng², H. Eisen³, B. D. Lowes⁴, L. Lourenco Jenkins⁵, Y. Fu⁵, K. Qu⁵, J. Teuteberg⁶, E. DePasquale⁷
¹Inova Heart and Vascular Institute, Falls Church, VA, ²University of Washington Heart Institute, Seattle, WA, ³Pennsylvania State University, Hershey, PA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵CareDx, Brisbane, CA, ⁶Stanford University, Stanford, CA, ⁷University of Southern California, Los Angeles, CA
*Purpose: Changes in dd-cfDNA levels over time may identify patients with evolving alloimmune injury, providing complementary information to the donor fraction. We explored the dd-cfDNA…
2022 American Transplant Congress
Implementation of Infectious Disease Surveillance in Recently Deceased Human Xenograft Study
S. J. Cawthon, E. P. Weldon, N. S. Lawson, B. E. Lonze, R. A. Montgomery, S. A. Mehta
NYU Langone Transplant Institute, New York, NY
*Purpose: Xenotransplantation is a promising solution for the ongoing organ shortage but has been slow to develop because of both immunological challenges and potential risk…
2022 American Transplant Congress
A Composite Endpoint to Improve Upon the Srtr 5-Tier Rating System
R. Formica¹, K. Wang², Y. Deng², D. Stewart³
¹Yale School of Medicine, New Haven, CT, ²Yale School of Public Health, New Haven, CT, ³UNOS, Richmond, VA
*Purpose: Kidney transplant program performance in the US is monitored with outcome metrics used by regulatory agencies to assess provider quality and by patients to…
2022 American Transplant Congress
Delta Changes in Donor-Derived Cell-Free DNA (dd-cfDNA) Complement the Donor Fraction in Kidney Transplant Surveillance
A. Wiseman¹, M. Jagadeesan², G. Gupta³, V. Rao⁴, M. Narayanan⁵, N. Agrawal⁶, G. Shekhtman⁶, Y. Fu⁶, K. Pinney⁶, S. Anand⁷
¹Centura Health, Denver, CO, ²George Washington University, Washington, DC, ³Virginia Commonwealth University, Richmond, VA, ⁴Medical University of South Carolina, Charleston, SC, ⁵Baylor Scott and White, Austin, TX, ⁶CareDx, Brisbane, CA, ⁷Intermountain Healthcare, Murray, UT
*Purpose: Delta changes in dd-cfDNA levels over time may identify patients with evolving alloimmune injury, providing complementary information to the donor fraction. We explored the…
2021 American Transplant Congress
Novel Mixed Lymphocyte Reaction Monitoring System That Predicts Chronic Antibody- Mediated Rejection in Kidney Transplant Recipients
N. Iwahara¹, K. Hotta¹, T. Tanabe¹, D. Iwami², Y. Takada³, H. Higuchi¹, H. Sasaki³, H. Harada³, N. Shinohara¹
¹Hokkaido Univercity, Sapporo, Japan, ²Jichi Medical University, Shimotsuke, Japan, ³Sapporo City General Hospital, Sapporo, Japan
*Purpose: Chronic active antibody-mediated rejection (CAAMR) induced by de novo donor-specific antibodies (DSA) is the main cause of graft loss in the long-term. Currently, there…
2021 American Transplant Congress
Are Tacrolimus Concentrations Reduced with Direct-acting Antiviral Administration in Transplant Recipients?
K. Huang, K. Farrow, M. Christian
Pharmacy, Penn State Health Hershey Medical Center, Hershey, PA
*Purpose: To evaluate the effects of direct-acting antivirals (DAAs) on tacrolimus trough concentrations and clinical outcome and to assess the need for a priori dose…
2021 American Transplant Congress
Tacrolimus Shortage and the Rush to Convert: An Unexpected Burden on the System During the Covid-19 Pandemic?
N. Pilch, L. Johnson, M. Aldoughaim, N. Patel, F. Bartlett
Medical University of South Carolina, Charleston, SC
*Purpose: A national shortage of immediate release (IR) tacrolimus (FK) fully impacted our center in May 2020. The conversion process was immediately challenging during the…
2021 American Transplant Congress
Determining Endpoint Criteria in Ex Vivo Normothermic Limb Perfusion (EVNLP)
S. K. Pandey¹, A. Meyers¹, P. Sadeghi¹, V. Kopparthy¹, T. Xia¹, H. Brunengraber², S. Dasarathy³, A. Rampazzo¹, B. Bassiri Gharb¹
¹Plastic Surgery, Cleveland Clinic, Cleveland, OH, ²Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH, ³Department of Gastroenterology, Cleveland Clinic, Cleveland, OH
*Purpose: There are no established criteria for discontinuing EVNLP before irreversible muscle and endothelial cell damage occur. This study aimed to evaluate weight gain as…