Articles tagged "Monitoring"

2015 American Transplant Congress
Development and Validation of a Genotype Guided Tacrolimus Dosing Equation for African American (AA) Kidney Transplant Recipients
K. Sanghavi,¹ R. Brundage,¹ M. Miller,² D. Schaldt,³ A. Israni,³ W. Guan,⁴ W. Oetting,¹ R. Mannon,⁵ R. Remmel,¹ A. Matas,⁶ P. Jacobson.¹
¹College of Pharmacy, University of MN, Minneapolis, MN; ²Dept of Psychology, University of MN, Minneapolis, MN; ³Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Dept of Biostatistics, University of MN, Minneapolis, MN; ⁵Dept of Nephrology, University of AL, Birmingham, AL; ⁶Dept of Surgery, University of MN, Minneapolis, MN.
Tacrolimus (tac) has a strong exposure-response relationship with high inter-individual variability in troughs and dose. Tac dose requirements for AA patients are higher than Caucasians,…
2015 American Transplant Congress
Non-Invasive Immune Monitoring Assay in Transplant Recipients
M. Gasser,¹ I. Tsaur,² K. Lopau,¹ C. Germer,¹ A. Chandraker,³ A. Waaga-Gasser.¹
¹Department of Surgery I, University of Wuerzburg, Wuerzburg, Germany; ²Department of Urology, University of Frankfurt, Frankfurt, Germany; ³Transplantation Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
A reliable non-invasive assay of immune responsiveness would help to predict the development of chronic rejection, stable function or tolerance in transplant recipients. Our aim…
2015 American Transplant Congress
Generation, Cryopreservation, Function and In Vivo Fate of Ex-Vivo Expanded Cynomolgus
H. Guo,¹ H. Zhang,¹ L. Lu,¹ M. Ezzelarab,¹ A. Thomson.^1,2
¹Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Background:Foxp3+ regulatory T cells (Treg) function to promote immune tolerance and prevent immunopathogenesis. Preclinical studies have demonstrated that adoptive transfer of Treg prevents rejection of…
2015 American Transplant Congress
Alemtuzumab Induction Is Protective Against Acute Rejection in Kidney Recipients With Subtherapeutic Tacrolimus Concentrations
K. Szempruch, R.-A. Lee, R. Dupuis, J. Deyo, T. Kozlowski.
Transplant Surgery, University of North Carolina Hospitals, Chapel Hill, NC.
Purpose: To determine the effect of attaining early therapeutic tacrolimus (TAC) trough concentrations on biopsy-proven acute rejection (BPAR) within 12 months post-transplantation in adult kidney…
2015 American Transplant Congress
Assessment of Circulating HLA-Specific Alloreactive Memory B Cells Reveals Surreptitious Immunized Kidney Transplant Recipients at High Risk of Antibody-Mediated Rejection
M. Lúcia,¹ S. Luque,¹ E. Crespo,¹ J. Cruzado,^1,2 E. Melilli,² J. Martorell,³ J. Torras,^1,2 S. Gil-Vernet,² J. Grinyo,^1,2 O. Bestard.^1,2
¹Renal transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Catalunya, Spain; ²Experimental Nephrology Laboratory, IDIBELL, Barcelona, Catalunya, Spain; ³Histocompatibility Unit, Immunology Department, Hospital Clinic, Barcelona, Catalunya, Spain.
Even though current bead-based multiplex techniques enable an accurate assessment of circulating HLA-specific antibodies, a more comprehensive study of the humoral alloimmune response through the…
2015 American Transplant Congress
Electronic Health Service to Improve Therapeutic Drug Monitoring of Immunosuppressants
M. Barten,¹ J. Garbade,² I. Hausladen,² F. Mohr.²
¹Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; ²Cardiac Surgery, University Leipzig Heart Center, Leipzig, Germany.
PurposeTherapeutic drug monitoring (TDM) of immunosuppressants is critical to avoid rejection or toxic side effects by under- or over-immunosuppression after heart transplantation (HTx). Hence, in…
2015 American Transplant Congress
Significant Association Between Foxp3 Gene Polymorphism and Outcomes in HBV-Related Liver Transplant Patients
Y. Tanaka, V. Sapana, H. Ohdan.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Background: Previous studies have demonstrated that CD4+Foxp3+ regulatory T (Treg) cells regulate HBV-related disease progression. The present study investigated the association between Treg cells and…
2015 American Transplant Congress
The Correlation Between Donor Specific Antibodies and Heart Transplant Rejection
R. Bedard,¹ P. Jindra,² M. Manson,¹ M. Moaddab,¹ H. Mallidi,³ W. Etheridge,¹ A. Civitello,³ R. Kerman.²
¹CHI St. Luke's Health - Baylor St. Luke's Medical Center, Houston, TX; ²Immune Evaluation Laboratory, Baylor College of Medicine, Houston, TX; ³Texas Heart Institute, Baylor College of Medicine, Houston, TX.
The presence of donor specific HLA antibodies (DSA) has been shown to be detrimental to heart transplant (HTx) survival. Virtual crossmatching (VXM) offers a rapid…
2015 American Transplant Congress
Concerted T-Cell Activity Against Early and Late BKV-Antigens Is Necessary for Viral Clearance
B. Weist,^1,2 M. Schmueck,² M. Dziubianau,² P. Reinke,^1,2 N. Babel.^1,2
¹Department of Nephrology, Charite Universitaetsmedizin, Berlin, Germany; ²BCRT, Charite Universitaetsmedizin, Berlin, Germany.
Polyomavirus-BK (BKV) associated nephropathy is a known cause of graft failure. No specific therapy is established so far and viral load monitoring accompanied by adjustment…
2015 American Transplant Congress
Increased Frequency of Terminally Differentiated and Exhausted CD8+ T Cells Is Associated With Adverse Clinical Outcome After Mechanical Circulatory Support Device Implantation
J. Schaenman,¹ Y. Korin,² T. Sidwell,² G. Sunga,² G. Bondar,³ N. Wisniewski,³ M. Kwon,⁴ M. Cadeiras,³ M. Deng,³ E. Reed.²
¹Medicine/Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; ³Medicine/Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA; ⁴Cardiothoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Clinical outcomes vary after mechanical circulatory support device (MCSD) implantation, with some patients developing multi organ system dysfunction (MOD), sometimes leading to death. We hypothesized…