Articles tagged "Monitoring"

2015 American Transplant Congress
Assessment of Circulating HLA-Specific Alloreactive Memory B Cells Reveals Surreptitious Immunized Kidney Transplant Recipients at High Risk of Antibody-Mediated Rejection
M. Lúcia,¹ S. Luque,¹ E. Crespo,¹ J. Cruzado,^1,2 E. Melilli,² J. Martorell,³ J. Torras,^1,2 S. Gil-Vernet,² J. Grinyo,^1,2 O. Bestard.^1,2
¹Renal transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Catalunya, Spain; ²Experimental Nephrology Laboratory, IDIBELL, Barcelona, Catalunya, Spain; ³Histocompatibility Unit, Immunology Department, Hospital Clinic, Barcelona, Catalunya, Spain.
Even though current bead-based multiplex techniques enable an accurate assessment of circulating HLA-specific antibodies, a more comprehensive study of the humoral alloimmune response through the…
2015 American Transplant Congress
Electronic Health Service to Improve Therapeutic Drug Monitoring of Immunosuppressants
M. Barten,¹ J. Garbade,² I. Hausladen,² F. Mohr.²
¹Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; ²Cardiac Surgery, University Leipzig Heart Center, Leipzig, Germany.
PurposeTherapeutic drug monitoring (TDM) of immunosuppressants is critical to avoid rejection or toxic side effects by under- or over-immunosuppression after heart transplantation (HTx). Hence, in…
2015 American Transplant Congress
Significant Association Between Foxp3 Gene Polymorphism and Outcomes in HBV-Related Liver Transplant Patients
Y. Tanaka, V. Sapana, H. Ohdan.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Background: Previous studies have demonstrated that CD4+Foxp3+ regulatory T (Treg) cells regulate HBV-related disease progression. The present study investigated the association between Treg cells and…
2015 American Transplant Congress
The Correlation Between Donor Specific Antibodies and Heart Transplant Rejection
R. Bedard,¹ P. Jindra,² M. Manson,¹ M. Moaddab,¹ H. Mallidi,³ W. Etheridge,¹ A. Civitello,³ R. Kerman.²
¹CHI St. Luke's Health - Baylor St. Luke's Medical Center, Houston, TX; ²Immune Evaluation Laboratory, Baylor College of Medicine, Houston, TX; ³Texas Heart Institute, Baylor College of Medicine, Houston, TX.
The presence of donor specific HLA antibodies (DSA) has been shown to be detrimental to heart transplant (HTx) survival. Virtual crossmatching (VXM) offers a rapid…
2015 American Transplant Congress
Concerted T-Cell Activity Against Early and Late BKV-Antigens Is Necessary for Viral Clearance
B. Weist,^1,2 M. Schmueck,² M. Dziubianau,² P. Reinke,^1,2 N. Babel.^1,2
¹Department of Nephrology, Charite Universitaetsmedizin, Berlin, Germany; ²BCRT, Charite Universitaetsmedizin, Berlin, Germany.
Polyomavirus-BK (BKV) associated nephropathy is a known cause of graft failure. No specific therapy is established so far and viral load monitoring accompanied by adjustment…
2015 American Transplant Congress
Increased Frequency of Terminally Differentiated and Exhausted CD8+ T Cells Is Associated With Adverse Clinical Outcome After Mechanical Circulatory Support Device Implantation
J. Schaenman,¹ Y. Korin,² T. Sidwell,² G. Sunga,² G. Bondar,³ N. Wisniewski,³ M. Kwon,⁴ M. Cadeiras,³ M. Deng,³ E. Reed.²
¹Medicine/Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; ³Medicine/Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA; ⁴Cardiothoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Clinical outcomes vary after mechanical circulatory support device (MCSD) implantation, with some patients developing multi organ system dysfunction (MOD), sometimes leading to death. We hypothesized…
2015 American Transplant Congress
Anti-Donor T-Cell Immunity Is a Continuum Immune Process Favouring Subclinical Rejection After Kidney Transplantation
E. Crespo,¹ M. Lucia,¹ J. Cruzado,^1,2 S. Luque,¹ E. Melilli,² A. Manonelles,^1,2 N. Sala,² J. Grinyó,^1,2 O. Bestard.^1,2
¹Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; ²Nephrology Department and Renal Transplant Unit, Bellvitge University Hospital, Barcelona, Spain.
Subclinical T-cell mediated rejection (sc-TCR) accounts for a major cause of kidney allograft loss and is unexpectedly found in a rather important number of protocol…
2015 American Transplant Congress
Kynurenine Assay to Detect Inflammation in Transplant Patient: Clinical Results
D. Abendroth,¹ J. Kaden,² M. Marzinzig,¹ M. Stangl.³
¹Center of Surgery, University of Ulm, Ulm, Germany; ²Renal Transplant Center, Municipal Friedrichshain Hospital, Berlin, Germany; ³General, Visceral and Transplant Surgery, Ludwig-Maximilians-Universität, München, Munich, Germany.
Introduction: Ideal biomarker should be specific, sensitive, non-invasive, mirror the benefit of therapy and offer prognostic potential. We developed a test using a colorimetric assay…
2015 American Transplant Congress
T-Cell Mediated Vascular Rejection Can Be Identified By the Combined Measurement of Five Specific microRNAs in Blood
M. Matz,¹ K. Fabritius,¹ C. Lorkowski,¹ M. Dürr,¹ J. Gaedeke,¹ P. Durek,² J. Grün,² A. Goestemeyer,¹ F. Bachmann,¹ K. Wu,¹ B. Rudolph,¹ U. Weber,¹ C. Haftmann,² N. Unterwalder,³ N. Lachmann,¹ A. Radbruch,² H.-H. Neumayer,¹ M.-F. Mashreghi,² K. Budde.¹
¹University Medicine Charité, Berlin, Germany; ²German Rheumatism Research Centre, Berlin, Germany; ³Labor Berlin GmbH, Berlin, Germany.
MicroRNAs hold important roles in the regulation of gene expression. Their function has been correlated with kidney disease and they might represent a new class…
2015 American Transplant Congress
Post-Transplant Changes in Serum Creatinine and Beta-2 Microglobulin Predict Acute Tubular Necrosis in the Early Post-Transplant Period
P. Liu,¹ A. Djamali,^1,2 D. Kaufman,^2,1 B. Astor.¹
¹Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Purpose: To evaluate the utility of early post-transplant changes in serum creatinine (SCr) and beta-2 microglobulin (B2M) in differentiating acute tubular necrosis (ATN) and other…