Articles tagged "Monitoring"

2015 American Transplant Congress
Concerted T-Cell Activity Against Early and Late BKV-Antigens Is Necessary for Viral Clearance
B. Weist,^1,2 M. Schmueck,² M. Dziubianau,² P. Reinke,^1,2 N. Babel.^1,2
¹Department of Nephrology, Charite Universitaetsmedizin, Berlin, Germany; ²BCRT, Charite Universitaetsmedizin, Berlin, Germany.
Polyomavirus-BK (BKV) associated nephropathy is a known cause of graft failure. No specific therapy is established so far and viral load monitoring accompanied by adjustment…
2015 American Transplant Congress
Increased Frequency of Terminally Differentiated and Exhausted CD8+ T Cells Is Associated With Adverse Clinical Outcome After Mechanical Circulatory Support Device Implantation
J. Schaenman,¹ Y. Korin,² T. Sidwell,² G. Sunga,² G. Bondar,³ N. Wisniewski,³ M. Kwon,⁴ M. Cadeiras,³ M. Deng,³ E. Reed.²
¹Medicine/Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; ³Medicine/Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA; ⁴Cardiothoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Clinical outcomes vary after mechanical circulatory support device (MCSD) implantation, with some patients developing multi organ system dysfunction (MOD), sometimes leading to death. We hypothesized…
2015 American Transplant Congress
Anti-Donor T-Cell Immunity Is a Continuum Immune Process Favouring Subclinical Rejection After Kidney Transplantation
E. Crespo,¹ M. Lucia,¹ J. Cruzado,^1,2 S. Luque,¹ E. Melilli,² A. Manonelles,^1,2 N. Sala,² J. Grinyó,^1,2 O. Bestard.^1,2
¹Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; ²Nephrology Department and Renal Transplant Unit, Bellvitge University Hospital, Barcelona, Spain.
Subclinical T-cell mediated rejection (sc-TCR) accounts for a major cause of kidney allograft loss and is unexpectedly found in a rather important number of protocol…
2015 American Transplant Congress
Kynurenine Assay to Detect Inflammation in Transplant Patient: Clinical Results
D. Abendroth,¹ J. Kaden,² M. Marzinzig,¹ M. Stangl.³
¹Center of Surgery, University of Ulm, Ulm, Germany; ²Renal Transplant Center, Municipal Friedrichshain Hospital, Berlin, Germany; ³General, Visceral and Transplant Surgery, Ludwig-Maximilians-Universität, München, Munich, Germany.
Introduction: Ideal biomarker should be specific, sensitive, non-invasive, mirror the benefit of therapy and offer prognostic potential. We developed a test using a colorimetric assay…
2015 American Transplant Congress
T-Cell Mediated Vascular Rejection Can Be Identified By the Combined Measurement of Five Specific microRNAs in Blood
M. Matz,¹ K. Fabritius,¹ C. Lorkowski,¹ M. Dürr,¹ J. Gaedeke,¹ P. Durek,² J. Grün,² A. Goestemeyer,¹ F. Bachmann,¹ K. Wu,¹ B. Rudolph,¹ U. Weber,¹ C. Haftmann,² N. Unterwalder,³ N. Lachmann,¹ A. Radbruch,² H.-H. Neumayer,¹ M.-F. Mashreghi,² K. Budde.¹
¹University Medicine Charité, Berlin, Germany; ²German Rheumatism Research Centre, Berlin, Germany; ³Labor Berlin GmbH, Berlin, Germany.
MicroRNAs hold important roles in the regulation of gene expression. Their function has been correlated with kidney disease and they might represent a new class…
2015 American Transplant Congress
Post-Transplant Changes in Serum Creatinine and Beta-2 Microglobulin Predict Acute Tubular Necrosis in the Early Post-Transplant Period
P. Liu,¹ A. Djamali,^1,2 D. Kaufman,^2,1 B. Astor.¹
¹Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Purpose: To evaluate the utility of early post-transplant changes in serum creatinine (SCr) and beta-2 microglobulin (B2M) in differentiating acute tubular necrosis (ATN) and other…
2015 American Transplant Congress
Should Current IVIg Preparations Containing High Titers of Anti-HLA-I/-II IgG be Used for Lowering the Anti-HLA IgG in Sensitized Pre-Transplant Patients and Allograft Recipients?
M. Ravindranath, P. Terasaki, C. Maehara, V. Jucaud.
HLA antibodies, Terasaki Foundation Laboratory, Los Angeles, CA.
Sera of non-alloimmunized individuals contain anti-HLA-I & -II IgG. Therefore it is reasonable expect HLA-I/-II reactivity of Intravenous Immunoglobulin (IVIg). However, the titers at which…
2015 American Transplant Congress
Variants Associated With Tacrolimus Troughs in European American Kidney Transplant Recipients: A Genome Wide Association Study
P. Jacobson,¹ M. Miller,² D. Schladt,³ A. Israni,³ K. Sanghavi,¹ C. Dorr,³ R. Remmel,¹ W. Guan,⁴ A. Matas,⁵ W. Oetting.¹
¹College of Pharmacy, University of MN, Minneapolis, MN; ²Department of Psychology, University of MN, Minneapolis, MN; ³Department of Nephrology and Chronic Disease Research Group, Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Department of Biostatistics, University of MN, Minneapolis, MN; ⁵Department of Surgery, University of MN, Minneapolis, MN.
Tacrolimus (tac) is dependent on CYP3A4/5 for metabolism. Variability in the metabolism is influenced by CYP3A5*3 alleles. This variant and clinical factors explain around 50%…
2015 American Transplant Congress
Systemic and Local NK and Regulatory Cell Phenotypes and mTori-Induced Tumor-Specific Effector T-Cell Responses Are Key Players Favoring the Development of Squamous Cell Skin Carcinoma Among Kidney Transplant Patients
E. Crespo,¹ M. Lucia,¹ L. Fernandez,³ E. Melilli,² S. Luque,¹ R. Lauzurica,³ J. Cruzado,^1,2 J. Torras,^1,2 J. Grinyó,^1,2 O. Bestard.^1,2
¹Nephrology Laboratory, IDIBELL, Barcelona, Spain; ²Nephrology Department and Renal Transplant Unit, Bellvitge University Hospital, Barcelona, Spain; ³Kidney Transplant Unit, Germans Trias i Pujol University Hospital, Badalona, Spain.
Renal transplant patients are at higher risk of developing squamous cell carcinoma (SCC). Immunosuppressive agents promote an imbalance between effector and regulatory tumor-specific immune responses,…
2015 American Transplant Congress
Molecular Marker Strategies Supporting the Novartis US92 Study- A Discovery Study of Protein Biomarkers for Kidney Function (eGFR) and Acute Rejection in Serum from Renal Transplant Patients
U. Christians,¹ J. Klepacki,¹ A. Karimpour-fard,¹ G. Ingle,² D. Patel,² K. Johnson,³ D. Cibrik,³ J. Klawitter.¹
¹University of Colorado, Anschutz Medical Campus, Aurora, CO; ²Novartis Pharmaceuticals, East Hanover, NJ; ³University of Michigan Medical School, Ann Arbor, MI.
Purpose. Protein biomarkers have the potential to allow for earlier and more specific diagnosis of kidney injury in kidney transplant patients than established clinical markers…