2015 American Transplant Congress
Anti-Donor T-Cell Immunity Is a Continuum Immune Process Favouring Subclinical Rejection After Kidney Transplantation
Subclinical T-cell mediated rejection (sc-TCR) accounts for a major cause of kidney allograft loss and is unexpectedly found in a rather important number of protocol…2015 American Transplant Congress
Kynurenine Assay to Detect Inflammation in Transplant Patient: Clinical Results
Introduction: Ideal biomarker should be specific, sensitive, non-invasive, mirror the benefit of therapy and offer prognostic potential. We developed a test using a colorimetric assay…2015 American Transplant Congress
T-Cell Mediated Vascular Rejection Can Be Identified By the Combined Measurement of Five Specific microRNAs in Blood
MicroRNAs hold important roles in the regulation of gene expression. Their function has been correlated with kidney disease and they might represent a new class…2015 American Transplant Congress
Post-Transplant Changes in Serum Creatinine and Beta-2 Microglobulin Predict Acute Tubular Necrosis in the Early Post-Transplant Period
Purpose: To evaluate the utility of early post-transplant changes in serum creatinine (SCr) and beta-2 microglobulin (B2M) in differentiating acute tubular necrosis (ATN) and other…2015 American Transplant Congress
Should Current IVIg Preparations Containing High Titers of Anti-HLA-I/-II IgG be Used for Lowering the Anti-HLA IgG in Sensitized Pre-Transplant Patients and Allograft Recipients?
HLA antibodies, Terasaki Foundation Laboratory, Los Angeles, CA.
Sera of non-alloimmunized individuals contain anti-HLA-I & -II IgG. Therefore it is reasonable expect HLA-I/-II reactivity of Intravenous Immunoglobulin (IVIg). However, the titers at which…2015 American Transplant Congress
Variants Associated With Tacrolimus Troughs in European American Kidney Transplant Recipients: A Genome Wide Association Study
Tacrolimus (tac) is dependent on CYP3A4/5 for metabolism. Variability in the metabolism is influenced by CYP3A5*3 alleles. This variant and clinical factors explain around 50%…2015 American Transplant Congress
Systemic and Local NK and Regulatory Cell Phenotypes and mTori-Induced Tumor-Specific Effector T-Cell Responses Are Key Players Favoring the Development of Squamous Cell Skin Carcinoma Among Kidney Transplant Patients
Renal transplant patients are at higher risk of developing squamous cell carcinoma (SCC). Immunosuppressive agents promote an imbalance between effector and regulatory tumor-specific immune responses,…2015 American Transplant Congress
Molecular Marker Strategies Supporting the Novartis US92 Study- A Discovery Study of Protein Biomarkers for Kidney Function (eGFR) and Acute Rejection in Serum from Renal Transplant Patients
Purpose. Protein biomarkers have the potential to allow for earlier and more specific diagnosis of kidney injury in kidney transplant patients than established clinical markers…2015 American Transplant Congress
Evaluation of Natural Killer Cell Activation by NK Cell-Specific Interferon-Gamma-Releasing Assay
Introduction: Although NK cell activity (NKA) has a variety of measuring markers including chromiun release assay and flowcytometry-based cytolysis, limitations such as radioactivity and lack…2015 American Transplant Congress
Biomarker Panel Profile for Identification of High-Risk Patients After Heart Transplantation
Background: The first year after cardiac transplantation is critical for transplant survival and long-term outcome. Identification of suitable biomarkers for detection of rejection processes is…
American Transplant Congress abstracts