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Articles tagged "Monitoring"

  • 2019 American Transplant Congress

    Perception Of Hospital Staff On Transplant: Pre And Post-intervention

    J. Wise1, A. Sarvestani1, K. Briggs2, J. Malik2, M. Ott3, L. Markham3, H. Wilkins3, D. Neel2, C. Richart4, J. Foxworth1, M. Moncure2

    1University of Missouri - Kansas City, Kansas City, MO, 2Department of Surgery, University of Missouri - Kansas City, Kansas City, MO, 3Midwest Transplant Network, Kansas City, MO, 4Northeast Georgia Medical Center, Gainesville, GA

    *Purpose: A primary component in managing potential organ donors is working effectively and collaboratively in the multidisciplinary environment of the ICU. Fundamentals of Critical Care…
  • 2019 American Transplant Congress

    Four-Year Follow Up of Kidney Transplantation Using Alemtuzumab Induction and Belatacept/Sirolimus Maintenance Therapy

    A. Kirk1, H. Xu1, A. Ghali2, A. Mehta2, A. Guasch2

    1Surgery, Duke University, Durham, NC, 2Transplant Center, Emory University, Atlanta, GA

    *Purpose: Kidney transplantation remains limited by the chronic toxicities associated with calcineurin inhibitors (CNIs) and steroids. The objective of this clinical trial was to determine…
  • 2019 American Transplant Congress

    Impact of a Novel Digital Medicine Program on Adherence and Utilization in Pediatric Transplant Patients

    S. Sullivan1, K. N. Triplett1, C. Sacks2, M. Tran2, D. M. Desai3

    1Solid Organ Transplant, Children's Medical Center, Dallas, Dallas, TX, 2Proteus Digital Health, Redwood City, CA, 3Transplant Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, TX

    *Purpose: Purpose: Optimal allograft function and long-term graft survival depends on many factors, including adherence to a complex medication regimen. Methods of measuring adherence are…
  • 2019 American Transplant Congress

    The C-Statistic Provides No Information on the Accuracy of Program Evaluations or the Presence of Unmeasured Confounders

    A. Wey, N. Salkowski, B. Kasiske, M. Skeans, S. Gustafson, A. Israni, J. Snyder

    SRTR, Minneapolis, MN

    *Purpose: The C-statistic of risk-adjustment models is regularly used to assess accuracy of program evaluations or determine presence of unmeasured confounding. However, the C-statistic depends…
  • 2018 American Transplant Congress

    Non-Invasive Diagnostic of Renal Allograft Rejection via Urine Metabolites Using NMR-Spectroscopy

    M. Banas,1 S. Neumann,2 P. Pagel,2 D. Chittka,1 V. Pfahlert,2 B. Banas.1

    1Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; 2numares HEALTH, Regensburg, Germany.

    Introduction and BackgroundPost-transplant surveillance for acute rejection is typically based on regular monitoring of serum creatinine levels and consecutive biopsies upon functional renal impairment. Attempts…
  • 2018 American Transplant Congress

    High Grade Cytomegalovirus Viremia Events in Solid Organ Transplant Recipients: Description and Quality Improvement

    M. Spinner,1 V. Athans,1 C. Koval.2

    1Dept. of Pharmacy, Cleveland Clinic, Cleveland, OH; 2Dept. of Infectious Diseases, Cleveland Clinic, Cleveland, OH.

    Background: High grade cytomegalovirus viremia (HGCMVV) often results in symptomatic disease requiring IV antiviral therapy and is associated with CMV recurrence and resistance. We postulated…
  • 2018 American Transplant Congress

    Unique Gene Expression Signatures in Urine Distinguish BK Virus Nephropathy from Acute Rejection in Kidney Transplant Patients with Graft Dysfunction

    K. Keslar,1 P. Gotwald,1 W. Xu,2 A. Zmijewska,3 J. Chen,3 K. Newell,4 P. Heeger,5 J. Bromberg,6 R. Mannon,3 R. Fairchild,1 The CTOT Consortium.

    1Cleveland Clinic, Cleveland, OH; 2Nanostring Technologies, Seattle, WA; 3University of Alabama at Birmingham, Birmingham, AL; 4Emory University, Atlanta, GA; 5Icahn School of Medicine at Mt. Sinai, New York, NY; 6University of Maryland, Baltimore, MD.

    Acute cellular rejection and BK virus nephropathy both cause deteriorating graft function that can lead to graft loss. Distinguishing the two conditions rapidly and accurately…
  • 2018 American Transplant Congress

    Evaluation and Cost Burden of Inappropriately Drawn Immunosuppression Trough Levels in the Acute Care Setting at an Academic Medical Center

    A. Brown, J. Geyston, A. Agarwal, B. Jones, W. Ally.

    University of Virginia Health System, Charlottesville, VA.

    Trough drug levels in narrow therapeutic index medications, such as CNI and mTOR inhibitors are used to estimate total drug exposure. Inappropriately measured trough levels…
  • 2018 American Transplant Congress

    Origin and Pattern of Human Polyomaviruses Replication after Kidney Transplantation: A Prospective Study

    E. Favi,1 S. Delbue,2 C. Colico,1 P. Ferrante,2 S. Villani,2 I. Perna,2 N. Mondoni,2 A. Giussani,1 L. Clementoni,1 P. Messa,3 M. Ferraresso.1

    1Kidney Transplantation, Fondazione IRCCS Ca' Granda, Milan, Italy; 2Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; 3Nephrology, Fondazione IRCCS Ca' Granda, Milan, Italy.

    Background. Human Polyomaviruses (HPyVs) are able to establish latent infection in the kidney of the host. Immunosuppression is recognized risk factor for HPyVs reactivation. Besides…
  • 2018 American Transplant Congress

    The Effect of Tacrolimus Trough Level and Intrapatient Variability on the Transplant Outcomes in Kidney Transplantation

    J. Lee,1 J. Lee,1 Y. Jung,1 D. Kim,1 S. Song,2 J. Lee,3 J. Lee,1 M. Kim,1 S. Kim,1 Y. Kim,1 B. Kim,4 K. Huh.1

    1Surgery, Yonsei University College of Medicine, Seoul, Korea; 2Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; 3Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; 4Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.

    Background: Tacrolimus (TAC) is the mainstay of immunosuppression for kidney transplantation (KT). Although TAC has a narrow therapeutic index, appropriate trough concentrations of TAC have…
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