Articles tagged "Monitoring"

2019 American Transplant Congress
Patient Centered AUC-Monitoring of Tacrolimus Using Capillary Microsampling
M. T. Gustavsen, K. Midtvedt, N. Vethe, S. Bergan, A. Åsberg
Oslo University Hospital, Rikshospitalet, Oslo, Norway
*Purpose: To reduce unwanted side effects of Tacrolimus (Tac), improvement of dosing is warranted. Therapeutic drug monitoring (TDM) of Tac based on trough concentrations (C0)…
2019 American Transplant Congress
Pre Transplant Intact FGF 23 Modifies Post-Transplant Improvement in Cognition
J. A. Klein¹, A. Jurgensen¹, J. Stubbs¹, P. Rowe¹, D. Cibrik¹, W. Brooks², J. Burns³, Z. Lauer⁴, A. Gupta¹
¹Nephrology, University of Kansas Medical Center, Kansas City, KS, ²KU Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, ³Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, ⁴Internal Medicine, University of Kansas Medical Center, Kansas City, KS
*Purpose: Fibroblast growth factor 23 (FGF23) has been associated with cognitive impairment in ESRD. Both FGF23 levels and cognition improve post-kidney transplantation (KT). It is…
2019 American Transplant Congress
Significantly High FOXP3 mRNA in the Renal Allograft as a Mechanism of Tolerance Induced by Transient Mixed Chimerism in Non-Human Primates
M. Matsunami¹, I. Rosales¹, T. Oura¹, B. Adam², M. Mengel², R. Smith¹, A. Cosimi¹, R. Colvin¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: Treg-rich organized lymphoid structures (TOLS) has been identified in recipients with renal allograft tolerance induced by transient mixed chimerism in non-human primates (NHPs) and…
2019 American Transplant Congress
Impact of Clinical Trial Enrollment on Renal Transplant Outcomes
T. Shertel, A. Eisenhart
Saint Barnabas Medical Center, Livingston, NJ
*Purpose: The advancement of science and medicine begins with new therapies and techniques arriving through clinical trials. The possibility of improved patient outcomes may also…
2018 American Transplant Congress
Polyclonal Cellular Immune Function is Dose-Dependently Inhibited by Immunosuppressive Drugs but Has Limited Value in Predicting Infection or Rejection Episodes
S. Marx,¹ C. Adam,² S. Leyking,² U. Sester,² M. Sester.
¹Saarland University, Homburg/Saar, Germany; ²Saarland University, Homburg/Saar, Germany.
Background: Dosage of immunosuppressive drugs in transplant patients must be balanced to prevent graft rejection and infectious complications. Knowledge on general immune function may therefore…
2018 American Transplant Congress
Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in DCD Kidney Transplant Recipients
J. Bank,¹ R. Ruhaak,² D. Soonawala,¹ F. Romijn,² C. van Kooten,¹ C. Cobbaert,² H. de Fijter.¹
¹Nephrology, Leiden University Medical Center, Leiden, Netherlands; ²Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands.
Introduction: Tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) are promising biomarkers in acute kidney injury. Here, we investigated the performance…
2018 American Transplant Congress
Klotho, HMGB-1 and Kynurenine as Marker for Injury and Function in Renal Transplantation
M. Stangl,¹ D. Abendroth.²
¹Transplant Center Munich, Klinikum Großhadern, LMU Munich, Munich, Germany; ²Surgery, University of Ulm, Ulm, Germany.
Brain death is associated with immune activation and tissue injuries, counter regulated by activation of the tryptophan pathway producing kynurenine (Kyn). High mobility group box…
2018 American Transplant Congress
Clinical Validation of a Novel ELISpot-Based In Vitro Diagnostic Assay to Monitor CMV-Specific Cell-Mediated Immunity in Kidney Transplant Recipients
B. Banas,¹ D. Steubl,² L. Renders,² D. Chittka,¹ M. Banas,¹ T. Wekerle,³ M. Koch,⁴ O. Witzke,⁵ A. Muehlfeld,⁶ C. Sommerer,⁷ A. Habicht,⁸ C. Hugo,⁹ T. Huenig,¹⁰ M. Lindemann,⁵ T. Schmidt,¹¹ A. Rascle,¹¹ S. Barabas,¹¹ L. Deml,¹¹ R. Wagner,^1,11 B. Kraemer,¹² B. Krueger.¹²
¹University Clinic, Regensburg, Germany; ²Clinic rechts der Isar TUM, Munich, Germany; ³Medical University, Vienna, Austria; ⁴University Clinic, Hamburg-Eppendorf, Germany; ⁵University Hospital, Essen, Germany; ⁶Uniklinik RWTH, Aachen, Germany; ⁷University Hospital, Heidelberg, Germany; ⁸LMU Medical Center, Munich, Germany; ⁹University Hospital, Dresden, Germany; ¹⁰University Hospital, Wuerzburg, Germany; ¹¹Lophius Biosciences, Regensburg, Germany; ¹²UMM Uni. Heidelberg, Mannheim, Germany.
Impaired cytomegalovirus (CMV)-specific cell-mediated immunity (CMV-CMI) is a major cause ofCMV reactivation and associated complications in solid-organ transplantation. Reliably assessing CMV-CMI is desirable to individually…
2018 American Transplant Congress
Clinically Relevant Variation of Donor-Derived Cell-Free DNA during Longitudinal Surveillance of Renal Allografts
M. Narayanan,¹ T. Alhamad,² D. Hiller,³ J. Yee,³ R. Woodward,³ J. Bromberg.⁴
¹Texas A&M Health Science Center, Temple, TX; ²Washington University School of Medicine, St. Louis, MO; ³CareDx, Brisbane, CA; ⁴University of Maryland School of Medicine, Baltimore, MD.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) levels >1% are associated with active rejection in renal transplant recipients. This report defines the clinically relevant variation of dd-cfDNA…
2018 American Transplant Congress
Estimation of Beta Cell Function after Total Pancreatectomy with Islet Autotransplantation Using Single Fasting Blood Sample Based Indices and Modified Igls Score.
J. Gołębiewska,¹ P. Bachul,² L. Basto,² M. Kijek,² N. Fillman,² K. Cieply,² K. Golab,² L. Wang,² M. Tibudan,² C. Thomas,³ A. Dębska-Ślizień,¹ J. Fung,² P. Witkowski.²
¹Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland; ²Surgery, University of Chicago, Chicago; ³Medicine, University of Chicago, Chicago.
Background: For precise yet logistically feasible evaluation of beta-cell function after total pancreatectomy with islet autotransplantation (TPIAT), we investigated the utility of indices using only…