Articles tagged "Monitoring"

2019 American Transplant Congress
Significantly High FOXP3 mRNA in the Renal Allograft as a Mechanism of Tolerance Induced by Transient Mixed Chimerism in Non-Human Primates
M. Matsunami¹, I. Rosales¹, T. Oura¹, B. Adam², M. Mengel², R. Smith¹, A. Cosimi¹, R. Colvin¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: Treg-rich organized lymphoid structures (TOLS) has been identified in recipients with renal allograft tolerance induced by transient mixed chimerism in non-human primates (NHPs) and…
2019 American Transplant Congress
Impact of Clinical Trial Enrollment on Renal Transplant Outcomes
T. Shertel, A. Eisenhart
Saint Barnabas Medical Center, Livingston, NJ
*Purpose: The advancement of science and medicine begins with new therapies and techniques arriving through clinical trials. The possibility of improved patient outcomes may also…
2019 American Transplant Congress
Next Gen ABO Antibody Assessment: Development of a Bead-Based ABO Antibody Detection Assay
A. Halpin¹, J. Pearcey², B. Motyka², S. Maier², J. Zhou³, T. L. Lowary⁴, C. W. Cairo⁴, L. J. West¹
¹Dept of Pediatrics, Dept of Laboratory Medicine, GlycoNet, ATI, CDTRP, University of Alberta, Edmonton, AB, Canada, ²Dept of Pediatrics, ATI, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada, ³Dept of Laboratory Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Dept of Chemistry, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada
*Purpose: Accurate characterization of ABO antibodies (ABO-Ab) is critical to assess their impact in ABO incompatible (ABOi) transplantation. The current ABO-Ab detection method using erythrocyte…
2019 American Transplant Congress
Efficacious Home Processing of Urine for Messenger RNA Profiling: A Point-of-Care Approach for Molecular Monitoring of Kidney Transplant Recipients
C. Snopkowski¹, C. Li¹, S. Albakry¹, B. Botticelli¹, M. Cassidy¹, J. Lee¹, M. Lubetzky¹, D. Dadhania¹, H. Yang¹, R. Ding¹, T. Muthukumar¹, M. Suthanthiran²
¹WCM, NYC, NY, ²WCM, New York, NY
*Purpose: Urinary mRNA profiling has been validated in multi-center studies as a robust tool for monitoring kidney transplant recipients. Home processing of urine samples for…
2019 American Transplant Congress
Evaluating Adherence to Immunosuppressive Drugs through Trackyourmed® an Innovative Qr Code-Scanner App in Renal Transplantation: Preliminary Results from i-COM Trial
E. Melilli¹, M. Meneghini¹, N. Montero¹, A. Coloma¹, I. Revuelta², F. Moreso³, V. Torregrosa², J. Grinyo¹, O. Bestard¹
¹Renal Transplant Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain, ²Renal Transplant Unit, Hospital Clinic, Barcelona, Spain, ³Renal Transplant Unit, Vall D'Hebron Hospital, Barcelona, Spain
*Purpose: Low adherence to chronic immunosuppressive (IS) drugs has been recognized as a major cause of premature graft loss. Although erratic trough blood IS levels…
2019 American Transplant Congress
Prospective BK Virus Screening in the Early Post-Kidney Transplant Period: A Single Center Experience
N. Parrish¹, S. Stander², M. Anand², B. G. Abu Jawdeh², A. Govil²
¹UC Med Ctr, Cincinnati, OH, ²U Cincinnati, Cincinnati, OH
*Purpose: BK virus screening protocols for the early (up to post-transplant day 90) post kidney transplant (KT) period vary amongst kidney transplant centers. Most commonly,…
2019 American Transplant Congress
NK Cells Are Associated with Alloimmune Failure in Transplanted Children
E. T. Chambers¹, O. Martinez², M. Robien³, C. Chan¹, R. Ettenger⁴, P. Grimm⁵, H. Lee¹, E. Reed⁴, L. Stempora⁶, M. Sarwal⁷, B. Warshaw⁸, C. Zhao¹, A. D. Kirk⁶
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Stanford, Palo Alto, CA, ³NIH, Bethesda, MD, ⁴Pediatrics, UCLA, Los Angeles, CA, ⁵Pediatrics, Stanford, Stanford, CA, ⁶Surgery, Duke University, Durham, NC, ⁷Pediatrics, UCSF, San Francisco, CA, ⁸Pediatrics, Emory University, Atlanta, GA
*Purpose: Alloimmune failure, defined as the development of donor specific antibody (DSA) and/ or allograft rejection, remains a significant complication in pediatric kidney transplantation. NK…
2019 American Transplant Congress
Increase in Proinflammatory CD14++CD16+ Monocytes in Samples from Aspiration Cytology Compared with Peripheral Blood in Kidney Transplant Patients with Borderline Rejection
T. Vazquez-Sanchez¹, A. Caballero-Gonzalez², E. Sola¹, P. Ruiz-Esteban¹, E. Marques¹, J. Alonso-Titos¹, E. Palma¹, C. Jironda¹, M. Cabello¹, V. Lopez¹, P. Hidalgo¹, M. Leon¹, D. Hernandez¹
¹Nephrology, Hospital Regional Universitario de Málaga, Universidad de Málaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ²Immunology, Hospital Regional Universitario de Málaga, Universidad de Málaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain
*Purpose: Monocytes comprise a heterogeneous population divided according to the membrane expression level of their molecules. One of these populations is the CD14++CD16+, which presents…
2019 American Transplant Congress
Integration Of Business Intelligence (BI) Solution In Tertiary Renal Transplant Centre To Drive Clinical Decisions.
M. Heer, S. Yausis, P. R. Trevillian
Newcastle Transplant Unit, John Hunter Hospital, Newcastle, Australia
*Purpose: The future of medicine will be enabled by big data. With the promise of data-driven knowledge and decision-making, innovative big-data projects are ongoing in…
2019 American Transplant Congress
Undernutrition is Associated with Impaired T Cell Protective Immunity in Pediatric Kidney Transplantation
E. T. Chambers¹, C. Chan¹, R. Ettenger², P. Grimm³, E. Reed², M. Sarwal⁴, L. Stempora⁵, B. Warshaw⁶, C. Zhao¹, O. Martinez⁷, A. Kirk⁵
¹Pediatrics, Duke University, Durham, NC, ²Pediatrics, UCLA, Los Angeles, CA, ³Pediatrics, Stanford, Palo Alto, CA, ⁴Pediatrics, UCSF, San Francisco, CA, ⁵Surgery, Duke University, Durham, NC, ⁶Pediatrics, Emory University, Atlanta, GA, ⁷Surgery, Stanford, Palo Alto, CA
*Purpose: Undernutrition has been associated with T cell immune cell dysfunction and infectious complications in non-immunosuppressed children. Thus, we aimed to define T cell phenotypes…