2020 American Transplant Congress
Donor and Recipient Sex Affect Transplant Outcomes in an Age-Specific Fashion
*Purpose: Donor and recipient sex impact transplant outcomes. The biology of sex-specific alloimmune responses has not been studied in detail.*Methods: Using clinical data from more…2020 American Transplant Congress
A Mouse Model of Non-MHC Mismatches Recapitulates Chronic Allograft Dysfunction and I-IFTA
*Purpose: Fibrotic and atrophic changes or IF/TA is an important cause of graft loss. We reported that genome-wide donor-recipient non-HLA mismatches independently correlate with Banff…2019 American Transplant Congress
Autoantibody Production Significantly Decreased with APRIL/BLyS Blockade in Murine Chronic Rejection Kidney Transplant Model
University of Wisconsin, Madison, WI
*Purpose: Chronic antibody mediated rejection (cAMR) remains a significant barrier to achieving long-term graft survival in kidney transplantation. Alloantibody production from B lymphocytes and plasma…2019 American Transplant Congress
Analysis and Regulation of Immune Reaction in the Transplantation from MHC Homozygous Donors to Heterozygous Recipients with Minor Antigen Mismatches
Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
*Purpose: Induced pluripotent stem cells (iPSCs) is expected to be the source of therapeutic cells in the regenerative medicine. Autologous derivation of iPSCs is the…2017 American Transplant Congress
mTORC1 and 2 Regulate Dendritic Cell (DC) Metabolism and Allostimulatory Function of Donor DCs in Skin Transplantation.
Background/Hypothesis: The mechanistic target of rapamycin (mTOR) is a kinase that functions in two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play critical…
American Transplant Congress abstracts