Articles tagged "Minor histocompatibility antigens"

2022 American Transplant Congress
Do Clinical & Pathologic Signs of Rejection Develop Following Transplantation of Tissue Containing Non-Autologous Mitochondria in an Autologous Nuclear Cloned Host?
S. Jacob¹, M. L. Baack², A. Savinov³, P. J. Wettstein⁴
¹Cardiothoracic Surgery and transplantation, Mayo Clinic, Jacksonville, FL, ²Division of Neonatology, University of South Dakota – Sanford School of Medicine, Sioux Falls, SD, ³Sanford Research, University of South Dakota School of Medicine, Sioux Falls, SD, ⁴Departments of Surgery and Immunology, Mayo Clinic, Rochester, MN
*Purpose: Recent studies have yielded conflicting results on the capacity of oocyte-encoded mtDNA polymorphisms to stimulate rejection . Therefore, there are still questions as to…
2020 American Transplant Congress
Donor and Recipient Sex Affect Transplant Outcomes in an Age-Specific Fashion
R. Maenosono¹, Y. Nian¹, J. Iske¹, Y. Liu¹, H. Azuma², E. Milford³, S. G. Tullius¹
¹Division of Transplant Surgery, Brigham and Women's Hospital, Boston, MA, ²Urology, Osaka Medical College, Osaka, Japan, ³Renal Division, Brigham and Women's Hospital, Boston, MA
*Purpose: Donor and recipient sex impact transplant outcomes. The biology of sex-specific alloimmune responses has not been studied in detail.*Methods: Using clinical data from more…
2020 American Transplant Congress
A Mouse Model of Non-MHC Mismatches Recapitulates Chronic Allograft Dysfunction and I-IFTA
V. Pavlov¹, F. Garzon¹, R. Haroon Al Rasheed², K. Banu¹, F. ElSalem¹, L. Li¹, E. Cody¹, M. Planoutene¹, N. Chun¹, Z. Zhang¹, J. Leventhal¹, B. Murphy¹, P. Heeger¹, M. C. Menon¹
¹Medicine, Mount Sinai School of Medicine, New York, NY, ²Pathology, Mount Sinai School of Medicine, New York, NY
*Purpose: Fibrotic and atrophic changes or IF/TA is an important cause of graft loss. We reported that genome-wide donor-recipient non-HLA mismatches independently correlate with Banff…
2019 American Transplant Congress
Autoantibody Production Significantly Decreased with APRIL/BLyS Blockade in Murine Chronic Rejection Kidney Transplant Model
N. Bath, X. Ding, B. Verhoven, S. Reese, N. Wilson, A. Sukhwal, R. Redfield III
University of Wisconsin, Madison, WI
*Purpose: Chronic antibody mediated rejection (cAMR) remains a significant barrier to achieving long-term graft survival in kidney transplantation. Alloantibody production from B lymphocytes and plasma…
2019 American Transplant Congress
Analysis and Regulation of Immune Reaction in the Transplantation from MHC Homozygous Donors to Heterozygous Recipients with Minor Antigen Mismatches
T. Murata, H. Wada, R. Otsuka, H. Tsuji, A. Sasaki, M. Baghdadi, K. Seino
Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
*Purpose: Induced pluripotent stem cells (iPSCs) is expected to be the source of therapeutic cells in the regenerative medicine. Autologous derivation of iPSCs is the…
2017 American Transplant Congress
mTORC1 and 2 Regulate Dendritic Cell (DC) Metabolism and Allostimulatory Function of Donor DCs in Skin Transplantation.
A. Watson,^1,2 H. Dai,^1,3 A. Menk,^4,5 G. Delgoffe,^4,5 A. Thomson.^1,2,3
¹Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh; ²Pathology, Univ. of Pittsburgh, Pittsburgh; ³Surgery, Univ. of Pittsburgh, Pittsburgh; ⁴Immunology, Univ. of Pittsburgh, Pittsburgh; ⁵Cancer Institute, Univ. of Pittsburgh, Pittsburgh
Background/Hypothesis: The mechanistic target of rapamycin (mTOR) is a kinase that functions in two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play critical…