Articles tagged "Microchimerism"

2021 American Transplant Congress
Immunologic Benefits of Maternal Living Donor Allografts in Pediatric Liver Transplantation: Less Rejection Episodes and No Evidence of De Novo Allosensitization
A. Barbetta¹, G. Meeberg², B. Rocque¹, S. Barhouma³, S. Gilmour⁴, F. Faytrouni⁵, O. Guttman⁵, P. Campbell⁴, J. Shapiro², J. Emamaullee¹
¹Surgery, Abdominal Transplant, University of Southern California, Los Angeles, CA, ²Surgery, University of Alberta, Edmonton, AB, Canada, ³University of Southern California, Los Angeles, CA, ⁴University of Alberta, Edmonton, AB, Canada, ⁵University of British Columbia, Vancouver, BC, Canada
*Purpose: Living donor liver transplantation (LDLT) offers improved graft and patient survival in pediatric liver transplant (LT) recipients. Prior studies have suggested immunological advantage when…
2019 American Transplant Congress
The Frequency of Tissue-Resident Donor T and NK Cells in Peripheral Blood after Lung Transplantation is Modulated by Normothermic Ex Vivo Lung Perfusion
C. S. Falk¹, B. Wiegmann², A. Hitz¹, R. Bellmas-Sanz¹, K. Bläsing¹, F. Ius², C. Kühn², M. Avsar², I. Tudorache², J. Kühne¹, F. Wandrer¹, A. Haverich², G. Warnecke²
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: The appearance of passenger donor lymphocytes in recipient blood after double lung transplantation has been described decades ago. However, neither their early kinetics, nor…
2018 American Transplant Congress
Mechanisms of Vascularized Bone Marrow Graft Protection of Vascularized Composite Allografts
E. Buckingham, N. Shockcor, W. Hassanein, C. Drachenberg, A. Nam, S. Bartlett, R. Barth.
Surgery, University of Maryland, Baltimore, MD.
Background Co-transplantation of vascularized bone marrow (VBM) promotes vascularized composite allograft (VCA) survival with standard immunosuppression in a non-human primate (NHP) model. We investigated mechanisms…
2017 American Transplant Congress
A Novel Method for Detecting and Monitoring Chimerism in Patients with Graft versus Host Disease After Liver Transplantation.
B. Peng, H. Liu, K. Cheng, Y. Zhao, X. She, Y. Niu, Q. Zhuang, Y. Ming.
Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Engineering & Technology Research Center for Transplantation Medicine, National Ministry of Health, Changsha, Hunan, China
Background Graft versus host disease (GVHD) after orthotopic liver transplantation (OLT) is a rare but lethal complication. Early diagnosis and treatment is critical for a…
2017 American Transplant Congress
Chimerism-Related Allotolerance Is Induced by Exosome Acquisition and Reprogramming of Host Dendritic Cells.
D. Lema,¹ W. Bracamonte-Baran,² E. Jankowska-Gan,¹ F. Claas,³ J. van Rood,³ A. Mulder,³ W. Burlingham.¹
¹Surgery - Transplant Division, University of Wisconsin-Madison, Madison, WI; ²Pathology, Division of Immunology, Johns Hopkins University, Baltimore, MD; ³Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands
Maternal microchimerism (MMc) has been associated with allo-specific graft tolerance in mice and humans. This tolerance is associated with membrane allo-antigen acquisition (mAAQ), which is…
2016 American Transplant Congress
The Effect of Donor-Recipient Relationship on the Immunologic Outcome in Living Kidney Transplantation.
D. Khadzhynov, F. Halleck, L. Lehner, M. Duerr, J. Waiser, K. Budde, O. Staeck.
Nephrology, Charite Campus Mitte, Berlin, Germany.
Background. Presensitization and degree of HLA-matching influences immunologic outcome and kidney graft survival. Thus the donor-recipient relationship may influence incidence of immunologic events and outcome…
2016 American Transplant Congress
Development of a Vascularized Thymus-Sternum Composite Tissue Allograft Model in Non-Human Primates.
N. O'Neill, S. Sendil, Y. Zhao, A. Hershfield, I. Tatarov, G. Braileanu, W. Hassanein, D. Parsell, A. Azimzadeh, L. Burdorf, R. Pierson, A. Nam.
Surgery, University of Maryland, Baltimore, MD.
Purpose: Vascularized composite allotransplantation (VCA) has demonstrated clinical success with standard immunosuppressive strategies in face, hand, and forearm transplantations. We developed a non-human primate model…
2016 American Transplant Congress
HLA Identical Renal Transplant Tolerance Using Donor Hematopoietic Stems Cells (DHSC): Role of Immunoregulation.
J. Leventhal,¹ J. Mathew,¹ D. Salomon,² S. Kurian,² J. Friedewald,¹ L. Gallon,¹ X. Huang,¹ A. Tambur,¹ Y. Kanwar,¹ J. Charette,¹ M. Abecassis,¹ J. Miller.¹
¹Surgery - Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²The Scripps Research Institute, La Jolla, CA.
Purpose: Despite being a “perfect match”, HLA-identical kidney transplants (HLA-Id KTx) are rejected without sufficient immunosuppression (IS), and hence can also benefit from tolerance induction.…
2015 American Transplant Congress
Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of of Molecular Chimerism in Murine Neonatal Tolerance
X. Wang,¹ H. Mewhort,¹ S. Wang,¹ S. Tollenaar,¹ K. Tao,¹ L. West.^1,2,3
¹Department of Pediatrics, University of Alberta, Edmonton, AB, Canada; ²Department of Surgery, University of Alberta, Edmonton, AB, Canada; ³Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada.
Background: Heart transplantation is a lifesaving measure for many infants with severe congenital heart diseases. The acceptance of cardiac allografts without immunosuppression, or operational tolerance,…
2015 American Transplant Congress
Microchimerism-Tolerance “Missing Link”: Exosome Acquisition by Host Dendritic Cells
W. Bracamonte-Baran, E. Jankowska-Gan, Y. Zhou, W. Burlingham.
Surgery, University of Wisconsin, Madison, WI.
Background: widespread maternal microchimerism (MMc) in mice is associated with development of immune regulation, which can be used to predict transplantation tolerance. We recently showed…