2015 American Transplant Congress
DNA Methytransferase 1 Inhibition Potently Suppresses T Cell Cycle Progression Through Demethylation of the Key Cell Cycle Inhibitors p15, p16, p21 and p27
Background: Epigenetic mechanisms like acetylation and methylation have been gradually appreciated to play a critical role in the generation and function of various immune cells.…2015 American Transplant Congress
The Role of an Intragraft Vascularized Bone Marrow Niche in Establishing Mixed Chimerism and Allograft Acceptance
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD.
Background: Vascularized composite allotransplantation has emerged as a viable treatment option for patients with devastating tissue loss not amenable to traditional reconstructive techniques. Different from…2015 American Transplant Congress
Oxidative Stress During Organ Recovery Influences Transplant Vasculopathy Development
Transplant vasculopathy is still a major obstacle to long-term graft survival. Pharmacological strategies aiming at preventing it are still lacking. Herein we show that the…2015 American Transplant Congress
Allograft Class II MHC and CD40 Expression Are Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…2015 American Transplant Congress
Single Infusion of Donor-Type Splenocytes Treated With Extracorporeal Photopheresis Prior to Transplantation Significantly Prolongs Cardiac Allograft Survival in Mice
Background: Extracorporeal Photopheresis (ECP) is an immune therapy in which blood leukocytes are treated with 8-methoxypsoralen (8-MOP), exposed to UV-A light, and re-infused. This study…2015 American Transplant Congress
Defining and Directing T Cell Subsets Involved in Rejection of Vascularized Composite Allografts
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD.
Purpose: Wider utilization of VCA is hampered by the need for long-term immunosuppression. Barriers to more targeted immunosuppression in VCA include (1) limited knowledge of…2015 American Transplant Congress
A Mouse Model of Pneumonitis Induced by Candida Albicans Infection After Allogeneic Skin Transplantation
Aims:Our study was to build up a mouse model of pneumonitis induced by candida albicans infection after allogeneic skin transplantation.Methods:We used 10 male C57BL/6J mice…
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