ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2015 American Transplant Congress

    DNA Methytransferase 1 Inhibition Potently Suppresses T Cell Cycle Progression Through Demethylation of the Key Cell Cycle Inhibitors p15, p16, p21 and p27

    T. Ma, Y. Pei, R. Tao.

    Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China.

    Background: Epigenetic mechanisms like acetylation and methylation have been gradually appreciated to play a critical role in the generation and function of various immune cells.…
  • 2015 American Transplant Congress

    The Role of an Intragraft Vascularized Bone Marrow Niche in Establishing Mixed Chimerism and Allograft Acceptance

    M. Fryer, B. Oh, G. Furtmüller, G. Raimondi, G. Brandacher.

    Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD.

    Background: Vascularized composite allotransplantation has emerged as a viable treatment option for patients with devastating tissue loss not amenable to traditional reconstructive techniques. Different from…
  • 2015 American Transplant Congress

    Oxidative Stress During Organ Recovery Influences Transplant Vasculopathy Development

    M. Maglione,1 G. Riede,1 B. Cardini,1 D. Bernhard,2 B. Messner,2 K. Watschinger,3 C. Steger,4 G. Brandacher,5 J. Pratschke,1 E. Werner,3 R. Oberhuber.1

    1Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria; 2Cardiac Surgery Research Laboratory, Department of Surgery, Vienna Medical University, Vienna, Austria; 3Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria; 4Institute of Pathology, Innsbruck Medical University, Innsbruck, Austria; 5Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

    Transplant vasculopathy is still a major obstacle to long-term graft survival. Pharmacological strategies aiming at preventing it are still lacking. Herein we show that the…
  • 2015 American Transplant Congress

    Allograft Class II MHC and CD40 Expression Are Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage

    T. Tanaka,1,2 H. Tsuda,1,3 N. Kohei,1,4 D. Kish,1 W. Baldwin,1 A. Valujskikh,1 R. Fairchild.1

    1Immunology, Cleveland Clinic, Cleveland, OH; 2Urology, Sapporo Medical University, Sapporo, Japan; 3Urology, Osaka University, Osaka, Japan; 4Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.

    Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
  • 2015 American Transplant Congress

    Single Infusion of Donor-Type Splenocytes Treated With Extracorporeal Photopheresis Prior to Transplantation Significantly Prolongs Cardiac Allograft Survival in Mice

    J. Schneiderman,1 J. Ye,2 X. Yeap,2 M. Caralt,2 J.-J. Wang,2 Z. Zhang.2

    1Ped Hematology/Oncology/Stem Cell Transplant, Feinberg School of Medicine Northwestern University, Chicago, IL; 2Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.

    Background: Extracorporeal Photopheresis (ECP) is an immune therapy in which blood leukocytes are treated with 8-methoxypsoralen (8-MOP), exposed to UV-A light, and re-infused. This study…
  • 2015 American Transplant Congress

    Defining and Directing T Cell Subsets Involved in Rejection of Vascularized Composite Allografts

    M. Fryer, G. Furtmùller, B. Oh, S. Reddy, K. Sarhane, G. Raimondi, G. Brandacher, D. Cooney.

    Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD.

    Purpose: Wider utilization of VCA is hampered by the need for long-term immunosuppression. Barriers to more targeted immunosuppression in VCA include (1) limited knowledge of…
  • 2015 American Transplant Congress

    A Mouse Model of Pneumonitis Induced by Candida Albicans Infection After Allogeneic Skin Transplantation

    A. Yang, Z. Guo, W. Ju, Y. Ma, A. Hu, Y. Chen, M. Chen, C. Wu, X. He.

    Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Aims:Our study was to build up a mouse model of pneumonitis induced by candida albicans infection after allogeneic skin transplantation.Methods:We used 10 male C57BL/6J mice…
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