ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2015 American Transplant Congress

    Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2)

    E. Yin,1,2 M. Uchiyama,1,3,4 X. Jin,1,5 T. Shimokawa,3 H. Yagita,4 M. Niimi.1

    1Department of Surgery, Teikyo University, Tokyo, Japan; 2Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; 3Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan; 4Department of Immunology, Juntendo University Hospital, Tokyo, Japan; 5Department of Cardiovascular and Thoracic Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.

    Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) and Programmed death (PD)-1 had been suggested to have immunomodulatory activity. This study investigated the…
  • 2015 American Transplant Congress

    miRNA-181 Promotes Graft Prolongation by Plasmacytoid Dendritic Cells By Increasing T Regulatory Cells and Decreasing B Cells as Revealed By Cytometry By Time-Of-Flight

    A. Lau,1,2 M. Vitalone,1 X. Qu,1 T. Shawler,1 O. Martinez,1 C. Esquivel,1 S. Krams.1

    1Surgery, Stanford University, Stanford, CA; 2Pediatrics, UCSF, San Francisco, CA.

    Liver allografts are well tolerated and other solid organ allografts, when transplanted concurrently with livers, show improved outcomes. However, the mechanisms underlying “hepatic tolerance” have…
  • 2015 American Transplant Congress

    Living and Dead Mesenchymal Stem Cells Induce an Immunosuppressive Response in an Experimental Sepsis Model

    F. Luk,1 M. Roemeling-van Rhijn,1 S. de Witte,1 S. Korevaar,1 R. de Bruin,2 M. Betjes,1 C. Baan,1 M. Hoogduijn.1

    1Nephrology and Transplantation, Dept. of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; 2Transplant Surgery, Dept. of Surgery, Erasmus Medical Center, Rotterdam, Netherlands.

    There is evolving interest in the use of mesenchymal stem cells (MSC) as a cell therapeutic agent after solid organ transplantation. The nature of the…
  • 2015 American Transplant Congress

    Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection

    S. Iida,1 T. Suzuki,2 K. Tanabe,1 A. Valujskikh,3 R. Fairchild,3 R. Abe.2

    1Urology, Tokyo Women's Medical Univ, Tokyo, Japan; 2Immunology, Science University of Tokyo, Chiba, Japan; 3Immunology, Cleveland Clinic, Cleveland, OH.

    【Background and Objective】: Lymphopenia is induced by lymphoablative therapies and chronic viral infections. Lymphopenia is observed in some pathological and physiological processes, including chronic viral…
  • 2015 American Transplant Congress

    MDSC Derived from iPS Cells Regulate the CD8 T Cell Response In Vivo

    D. Joyce,1 M. Morita,2 X.-K. Li,3 J. Fung,1 S. Qian,1,2 L. Lu.1,2

    1General Surgery, Digestive Disease Institute; 2Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 3Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

    Myeloid derived suppressor cells (MDSC) may represent a therapeutic tool for inducing tolerance in transplantation and autoimmune disorders. MDSC propagated from bone marrow (BM) can…
  • 2015 American Transplant Congress

    Proteasome Inhibition by Bortezomib Prevents Early Graft Failure After Pancreatic Islet Transplantation

    H. Ono,1 Y. Asahi,1 T. Yoshida,1 Y. Koshizuka,1 M. Watanabe,1 U. Tomaru,2 S. Emoto,1 M. Fukai,3 A. Taketomi,1 S. Todo,4 K. Yamashita.3

    1Gastroenterological Surgery1, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 2Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 3Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 4St Mary's Hospital, Kurume, Japan.

    Background: Islet graft loss caused by injurious inflammatory and innate immune responses, is a major obstacle in pancreatic islet transplantation (PIT). In this pathophysiology, the…
  • 2015 American Transplant Congress

    Expression Patterns of Neuropilin-1 On T Cells and a Potential Role in Transplantation

    E. Lee, H. Kim, G. Demirci.

    Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA.

    Introduction: Neuropilin-1 (NRP1) is a co-receptor for a variety of ligand families including VEGF, EGF and semaphorins all of which are often produced by malignant…
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