Articles tagged "Mice"

2015 American Transplant Congress
Altered Intestinal Microbiome as a Potential Biomarker for Failed Immune-Regulation in Autoimmune Type 1 Diabetes Mellitus
P. Chhabra,¹ A. Spano,² D. Bowers,¹ M. Wu,² L. Langman,¹ M. Timko,² K. Brayman.¹
¹Department of Surgery, University of Virginia, Charlottesville, VA; ²Department of Biology, University of Virginia, Charlottesville, VA.
Purpose: Beta-cell destruction results due to a failure of immune-regulation in type 1 diabetes (T1D). We investigated alterations in the intestinal microbiome composition as a…
2015 American Transplant Congress
Impact of CXCR4/CXCL12 Blockade on Normal Plasma Cells In Vivo
N. Moore,¹ M. Moreno Gonzales,² M. Stegall.¹
¹Department of Surgery, Division of Transplant Surgery and Department of Immunology, Mayo Clinic, Rochester, MN; ²Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, MN.
Receptor/ligand interactions in stromal microenvironments play important roles in the localization, development and survival of normal antibody-secreting plasma cells. The goal of the current study…
2015 American Transplant Congress
B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Response After Transplantation
J. Marino, P. Crosby Bertorini, J. Paster, A. Trowell, K. Briggs, L. Maxwell, G. Benichou.
Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA.
Pre-transplant B cell depletion in NHP with Rituximab (IgG1 anti-CD20 mAb) combined with cyclosporin A has been shown to promote the survival of islets allografts.…
2015 American Transplant Congress
Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of of Molecular Chimerism in Murine Neonatal Tolerance
X. Wang,¹ H. Mewhort,¹ S. Wang,¹ S. Tollenaar,¹ K. Tao,¹ L. West.^1,2,3
¹Department of Pediatrics, University of Alberta, Edmonton, AB, Canada; ²Department of Surgery, University of Alberta, Edmonton, AB, Canada; ³Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada.
Background: Heart transplantation is a lifesaving measure for many infants with severe congenital heart diseases. The acceptance of cardiac allografts without immunosuppression, or operational tolerance,…
2015 American Transplant Congress
Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization
N.-N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
[bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…
2015 American Transplant Congress
Eomes-Expressing CD8+ T Cells and Th17 Cells Mediate Costimulatory Blockade-Resistant Allograft Rejection in Mice
M. Sabet-Baktach,¹ E. Eggenhofer,¹ P. Renner,¹ M. Lantow,¹ H. Schlitt,¹ E. Geissler,¹ A. Kroemer.^1,2
¹Department of Surgery, University Hospital Regensburg, Regensburg, Germany; ²Georgetown Transplant Institute, Georgetown Transplant Institute, Washington, DC.
The etiology of costimulatory blockade-resistant allograft rejection remains unclear. Therefore, the purpose of this study was to evaluate the responsiveness of distinct CD4+ and CD8+…
2015 American Transplant Congress
CD8⁺TCR^– Bone Marrow Facilitating Cells Prime Migration and Enhance Homing of Hematopoietic Stem and Progenitor Cells
Y. Wen,¹ Y. Huang,¹ T. Miller,¹ S. Ildstad.^1,2
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Regenerex, LLC, Louisville, KY.
We recently reported the induction of chimerism and tolerance to renal allografts without GVHD or engraftment syndrome in HLA-mismatched living donor renal transplant recipients through…
2015 American Transplant Congress
Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation
T. Ueno,^1,2,3 M. Yeung,¹ M. McGrath,¹ H. Iwamoto,³ Y. Nakamura,³ O. Konnno,³ Y. Kihara,³ T. Yokoyama,³ S. Ono,³ T. Ikeda,³ S. Kawachi,³ B. Ibrahim,¹ A. Chandraker.¹
¹Renal, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Transplant Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.
Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…
2015 American Transplant Congress
Donor MHC Independent Rejection of Islet Allografts in Autoimmune NOD Mice
A. Burrack,¹ K. Beard,² M. Coulombe,² R. Gill.²
¹Medicine, University of Minnesota, Minneapolis, MN; ²Surgery and Immunology, University of Colorado Denver, Aurora, CO.
In autoimmune Type 1 diabetes (T1D), pancreatic islet allografts have somewhat limited long-term survival, both in T1D human subjects and in spontaneously diseased non-obese diabetic…
2015 American Transplant Congress
Effectiveness of Neovascularization Surrounding Engrafted Islets by Matrigel With Additional Growth Factors in Intramuscular Islet Transplantation
G. Yoshimatsu,^1,2 N. Sakata,² H. Tsuchiya,² M. Takita,³ M. Levy,³ B. Naziruddin,³ M. Unno.²
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
Introduction: Intramuscular islet transplantation is one of the promising transplant sites because of safety, easy accessibility and less invasive procedure. However the efficacy of the…